L-Carnitine supplementation improves the behavioral symptoms in autistic children / Sarah Farid FAHMY in Research in Autism Spectrum Disorders, 7-1 (January 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.159-66 Titre : L-Carnitine supplementation improves the behavioral symptoms in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Sarah Farid FAHMY, Auteur ; Manal H. EL-HAMAMSY, Auteur ; Osama K. ZAKI, Auteur ; Osama A. BADARY, Auteur Année de publication : 2013 Article en page(s) : p.159-66 Langues : Anglais (eng) Mots-clés : Autism  l-Carnitine  CARS Index. décimale : PER Périodiques Résumé : l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] L-Carnitine supplementation improves the behavioral symptoms in autistic children [Texte imprimé et/ou numérique] / Sarah Farid FAHMY, Auteur ; Manal H. EL-HAMAMSY, Auteur ; Osama K. ZAKI, Auteur ; Osama A. BADARY, Auteur . - 2013 . - p.159-66. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.159-66 Mots-clés : Autism  l-Carnitine  CARS Index. décimale : PER Périodiques Résumé : l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

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