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L-Carnitine supplementation improves the behavioral symptoms in autistic children / Sarah Farid FAHMY in Research in Autism Spectrum Disorders, 7-1 (January 2013)
[article]
Titre : L-Carnitine supplementation improves the behavioral symptoms in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Sarah Farid FAHMY, Auteur ; Manal H. EL-HAMAMSY, Auteur ; Osama K. ZAKI, Auteur ; Osama A. BADARY, Auteur Année de publication : 2013 Article en page(s) : p.159-66 Langues : Anglais (eng) Mots-clés : Autism l-Carnitine CARS Index. décimale : PER Périodiques Résumé : l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.159-66[article] L-Carnitine supplementation improves the behavioral symptoms in autistic children [Texte imprimé et/ou numérique] / Sarah Farid FAHMY, Auteur ; Manal H. EL-HAMAMSY, Auteur ; Osama K. ZAKI, Auteur ; Osama A. BADARY, Auteur . - 2013 . - p.159-66.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.159-66
Mots-clés : Autism l-Carnitine CARS Index. décimale : PER Périodiques Résumé : l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 Using the Autism Detection in Early Childhood (ADEC) and Childhood Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children with Autism Spectrum Disorders / Yong-Hwee NAH in Journal of Autism and Developmental Disorders, 44-9 (September 2014)
[article]
Titre : Using the Autism Detection in Early Childhood (ADEC) and Childhood Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yong-Hwee NAH, Auteur ; Robyn L. YOUNG, Auteur ; Neil BREWER, Auteur Article en page(s) : p.2301-2310 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Predictive validity ADEC CARS Long term outcomes Index. décimale : PER Périodiques Résumé : This study evaluated the predictive validity of the Autism Detection in Early Childhood (ADEC; Young, Autism detection in early childhood: ADEC. Australian Council of Educational Research, Camberwell, VIC 2007) and a well-established screening tool, the Childhood Autism Rating Scale (CARS; Schopler et al. The childhood autism rating scale (CARS). Western Psychological Services, Los Angeles 1988), for long term outcomes of children with ASD engaged in an early intervention program. Participants were 55 children (44 male, 11 female) aged 19–42 months (M = 33.5, SD = 5.6) at initial assessment who were followed up 2 and 6 years after their initial assessment. The ADEC and the CARS performed similarly when predicting long term outcomes such as clinical diagnostic outcome and overall adaptive functioning level. However, only the ADEC score was significantly correlated with ASD symptom severity at the 6-year follow up. Although these findings need to be replicated with additional and larger samples, this study extends our understanding of the psychometric properties of both the ADEC and the CARS. En ligne : http://dx.doi.org/10.1007/s10803-014-2102-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Journal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2301-2310[article] Using the Autism Detection in Early Childhood (ADEC) and Childhood Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Yong-Hwee NAH, Auteur ; Robyn L. YOUNG, Auteur ; Neil BREWER, Auteur . - p.2301-2310.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2301-2310
Mots-clés : Autism spectrum disorders Predictive validity ADEC CARS Long term outcomes Index. décimale : PER Périodiques Résumé : This study evaluated the predictive validity of the Autism Detection in Early Childhood (ADEC; Young, Autism detection in early childhood: ADEC. Australian Council of Educational Research, Camberwell, VIC 2007) and a well-established screening tool, the Childhood Autism Rating Scale (CARS; Schopler et al. The childhood autism rating scale (CARS). Western Psychological Services, Los Angeles 1988), for long term outcomes of children with ASD engaged in an early intervention program. Participants were 55 children (44 male, 11 female) aged 19–42 months (M = 33.5, SD = 5.6) at initial assessment who were followed up 2 and 6 years after their initial assessment. The ADEC and the CARS performed similarly when predicting long term outcomes such as clinical diagnostic outcome and overall adaptive functioning level. However, only the ADEC score was significantly correlated with ASD symptom severity at the 6-year follow up. Although these findings need to be replicated with additional and larger samples, this study extends our understanding of the psychometric properties of both the ADEC and the CARS. En ligne : http://dx.doi.org/10.1007/s10803-014-2102-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Chinese children with autism: A multiple chemical elements profile in erythrocytes / J. WU in Autism Research, 11-6 (June 2018)
[article]
Titre : Chinese children with autism: A multiple chemical elements profile in erythrocytes Type de document : Texte imprimé et/ou numérique Auteurs : J. WU, Auteur ; D. J. LIU, Auteur ; X. J. SHOU, Auteur ; J. S. ZHANG, Auteur ; F. C. MENG, Auteur ; Y. Q. LIU, Auteur ; S. P. HAN, Auteur ; R. ZHANG, Auteur ; J. Z. JIA, Auteur ; J. Y. WANG, Auteur ; J. S. HAN, Auteur Article en page(s) : p.834-845 Langues : Anglais (eng) Mots-clés : Asd Cars autism erythrocyte essential minerals multi-elements rare earth elements toxic metals Index. décimale : PER Périodiques Résumé : Several lines of evidence suggested that abnormal levels of certain chemical elements may contribute to the development of autism spectrum disorders (ASD). The present work aimed to investigate the multiple chemical elements profile in the erythrocytes of autistic versus typically developing children (TDC) of China. Analyses were carried out to explore the possible association between levels of elements and the risk as well as the severity of ASD. Erythrocyte levels of 11 elements (32%) among 34 detected elements in autistic group were significantly different from those in the TDC group. To our knowledge, this is the first study which compared the levels of rare earth elements in erythrocytes between children with or without ASD. Five elements including Pb, Na, Ca, Sb, and La are associated with the Childhood Autism Rating Scale (CARS) total score. Also, a series of tendencies were found in this research which was believed to affect auditory response, taste, smell, and touch, as well as fear or nervousness. It can be concluded that Chinese autistic children suffer from multi-chemical element imbalances which involves a complex combination of genetic and environmental factors. The results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. LAY SUMMARY: It is suggested that abnormal levels of some chemical elements may contribute to the development of autism spectrum disorders (ASD). In this work, the impact of element imbalances on the risk and severity of ASD was investigated, focusing on the analysis of abnormal levels of the multi-chemical elements profile in erythrocytes compared with typically developing children. Furthermore, the results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. Autism Res 2018, 11: 834-845. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Autism Research > 11-6 (June 2018) . - p.834-845[article] Chinese children with autism: A multiple chemical elements profile in erythrocytes [Texte imprimé et/ou numérique] / J. WU, Auteur ; D. J. LIU, Auteur ; X. J. SHOU, Auteur ; J. S. ZHANG, Auteur ; F. C. MENG, Auteur ; Y. Q. LIU, Auteur ; S. P. HAN, Auteur ; R. ZHANG, Auteur ; J. Z. JIA, Auteur ; J. Y. WANG, Auteur ; J. S. HAN, Auteur . - p.834-845.
Langues : Anglais (eng)
in Autism Research > 11-6 (June 2018) . - p.834-845
Mots-clés : Asd Cars autism erythrocyte essential minerals multi-elements rare earth elements toxic metals Index. décimale : PER Périodiques Résumé : Several lines of evidence suggested that abnormal levels of certain chemical elements may contribute to the development of autism spectrum disorders (ASD). The present work aimed to investigate the multiple chemical elements profile in the erythrocytes of autistic versus typically developing children (TDC) of China. Analyses were carried out to explore the possible association between levels of elements and the risk as well as the severity of ASD. Erythrocyte levels of 11 elements (32%) among 34 detected elements in autistic group were significantly different from those in the TDC group. To our knowledge, this is the first study which compared the levels of rare earth elements in erythrocytes between children with or without ASD. Five elements including Pb, Na, Ca, Sb, and La are associated with the Childhood Autism Rating Scale (CARS) total score. Also, a series of tendencies were found in this research which was believed to affect auditory response, taste, smell, and touch, as well as fear or nervousness. It can be concluded that Chinese autistic children suffer from multi-chemical element imbalances which involves a complex combination of genetic and environmental factors. The results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. LAY SUMMARY: It is suggested that abnormal levels of some chemical elements may contribute to the development of autism spectrum disorders (ASD). In this work, the impact of element imbalances on the risk and severity of ASD was investigated, focusing on the analysis of abnormal levels of the multi-chemical elements profile in erythrocytes compared with typically developing children. Furthermore, the results showed a significant correlation between abnormal levels of several chemical elements and the severity of the autistic syndrome. Autism Res 2018, 11: 834-845. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka / Hashan PEIRIS in Autism Research, 15-7 (July 2022)
[article]
Titre : Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka Type de document : Texte imprimé et/ou numérique Auteurs : Hashan PEIRIS, Auteur ; Darshana Chitraka WICKRAMARACHCHI, Auteur ; Pradeepa SAMARASINGHE, Auteur ; Philip VANCE, Auteur ; Dulangi DAHANAYAKE, Auteur ; Veerandi KULASEKARA, Auteur ; Madhuka NADEESHANI, Auteur Article en page(s) : p.1358-1367 Langues : Anglais (eng) Mots-clés : Asd ASD diagnosing standards ASD predictors Cars autism classification cultural factors logistic regression low-income countries Index. décimale : PER Périodiques Résumé : Use of autism diagnosing standards in low-income countries (LICs) are restricted due to the high price and unavailability of trained health professionals. Furthermore, these standards are heavily skewed towards developed countries and LICs are underrepresented. Due to such constraints, many LICs use their own ways of assessing autism. This is the first retrospective study to analyze such local practices in Sri Lanka. The study was conducted at Ward 19B of Lady Ridgeway Hospital (LRH) using the clinical forms filled for diagnosing ASD. In this study, 356 records were analyzed, from which 79.5% were boys and the median age was 33?months. For each child, the clinical form together with the Childhood Autism Rating Scale (CARS) value were recorded. In this study, a Clinically Derived Autism Score (CDAS) is obtained from the clinical forms. Scatter plot and Pearson product moment correlation coefficient were used to benchmark CDAS with CARS, and it was found CDAS to be positively and moderately correlated with CARS. In identifying the significant variables, a logistic regression model was built based on clinically observed data and it evidenced that "Eye Contact," "Interaction with Others," "Pointing," "Flapping of Hands," "Request for Needs," "Rotate Wheels," and "Line up Things" variables as the most significant variables in diagnosing autism. Based on these significant predictors, the classification tree was built. The pruned tree depicts a set of rules, which could be used in similar clinical environments to screen for autism. LAY SUMMARY: Screening and diagnosing autism in low-income countries such as Sri Lanka has always been a challenge due to limited resources and not being able to afford global standards. Due to these challenges, locally developed clinical forms have been used. This study is the first to analyze a clinical record set for autism in Sri Lanka to benchmark the local clinic form with a global standard. Furthermore, this study identifies the most significant diagnostic symptoms for children and based on these significant features, a simple set of IF-THEN rules are derived which could be used for screening autism in a similar clinical environment by health officials in the absence of consultants. En ligne : http://dx.doi.org/10.1002/aur.2765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Autism Research > 15-7 (July 2022) . - p.1358-1367[article] Diagnosing autism in low-income countries: Clinical record-based analysis in Sri Lanka [Texte imprimé et/ou numérique] / Hashan PEIRIS, Auteur ; Darshana Chitraka WICKRAMARACHCHI, Auteur ; Pradeepa SAMARASINGHE, Auteur ; Philip VANCE, Auteur ; Dulangi DAHANAYAKE, Auteur ; Veerandi KULASEKARA, Auteur ; Madhuka NADEESHANI, Auteur . - p.1358-1367.
Langues : Anglais (eng)
in Autism Research > 15-7 (July 2022) . - p.1358-1367
Mots-clés : Asd ASD diagnosing standards ASD predictors Cars autism classification cultural factors logistic regression low-income countries Index. décimale : PER Périodiques Résumé : Use of autism diagnosing standards in low-income countries (LICs) are restricted due to the high price and unavailability of trained health professionals. Furthermore, these standards are heavily skewed towards developed countries and LICs are underrepresented. Due to such constraints, many LICs use their own ways of assessing autism. This is the first retrospective study to analyze such local practices in Sri Lanka. The study was conducted at Ward 19B of Lady Ridgeway Hospital (LRH) using the clinical forms filled for diagnosing ASD. In this study, 356 records were analyzed, from which 79.5% were boys and the median age was 33?months. For each child, the clinical form together with the Childhood Autism Rating Scale (CARS) value were recorded. In this study, a Clinically Derived Autism Score (CDAS) is obtained from the clinical forms. Scatter plot and Pearson product moment correlation coefficient were used to benchmark CDAS with CARS, and it was found CDAS to be positively and moderately correlated with CARS. In identifying the significant variables, a logistic regression model was built based on clinically observed data and it evidenced that "Eye Contact," "Interaction with Others," "Pointing," "Flapping of Hands," "Request for Needs," "Rotate Wheels," and "Line up Things" variables as the most significant variables in diagnosing autism. Based on these significant predictors, the classification tree was built. The pruned tree depicts a set of rules, which could be used in similar clinical environments to screen for autism. LAY SUMMARY: Screening and diagnosing autism in low-income countries such as Sri Lanka has always been a challenge due to limited resources and not being able to afford global standards. Due to these challenges, locally developed clinical forms have been used. This study is the first to analyze a clinical record set for autism in Sri Lanka to benchmark the local clinic form with a global standard. Furthermore, this study identifies the most significant diagnostic symptoms for children and based on these significant features, a simple set of IF-THEN rules are derived which could be used for screening autism in a similar clinical environment by health officials in the absence of consultants. En ligne : http://dx.doi.org/10.1002/aur.2765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Diagnosing Autism Spectrum Disorder in Children with Low Mental Age / L. E. MILLER in Journal of Autism and Developmental Disorders, 49-3 (March 2019)
[article]
Titre : Diagnosing Autism Spectrum Disorder in Children with Low Mental Age Type de document : Texte imprimé et/ou numérique Auteurs : L. E. MILLER, Auteur ; J. D. BURKE, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur Article en page(s) : p.1080-1095 Langues : Anglais (eng) Mots-clés : Ados Autism spectrum disorder Cars Low mental age Symptom profiles Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) diagnostic tools are not designed for mental ages (MA) below 12 months. Autism Diagnostic Observation Schedule (ADOS) and Childhood Autism Rating Scale (CARS) were examined in 2-year-olds with ASD-low MA (n = 53), Global Developmental Delay (GDD; n = 175), and ASD-higher MA (n = 425). ADOS and CARS demonstrated similar agreement with clinical diagnosis, but ADOS over-classified ASD in low MA, whereas CARS both over- and under-classified. All ADOS items differentiated GDD from ASD. Elementary social behaviors (e.g., eye contact, social interest) were similar across ASD groups, although advanced skills (e.g., pointing, play) were more impaired in ASD-low MA. ASD-low MA, a severe presentation, may require a modified ADOS algorithm to account for developmental delays. En ligne : http://dx.doi.org/10.1007/s10803-018-3810-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1080-1095[article] Diagnosing Autism Spectrum Disorder in Children with Low Mental Age [Texte imprimé et/ou numérique] / L. E. MILLER, Auteur ; J. D. BURKE, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur . - p.1080-1095.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1080-1095
Mots-clés : Ados Autism spectrum disorder Cars Low mental age Symptom profiles Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) diagnostic tools are not designed for mental ages (MA) below 12 months. Autism Diagnostic Observation Schedule (ADOS) and Childhood Autism Rating Scale (CARS) were examined in 2-year-olds with ASD-low MA (n = 53), Global Developmental Delay (GDD; n = 175), and ASD-higher MA (n = 425). ADOS and CARS demonstrated similar agreement with clinical diagnosis, but ADOS over-classified ASD in low MA, whereas CARS both over- and under-classified. All ADOS items differentiated GDD from ASD. Elementary social behaviors (e.g., eye contact, social interest) were similar across ASD groups, although advanced skills (e.g., pointing, play) were more impaired in ASD-low MA. ASD-low MA, a severe presentation, may require a modified ADOS algorithm to account for developmental delays. En ligne : http://dx.doi.org/10.1007/s10803-018-3810-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Factor Analysis of the Childhood Autism Rating Scale in a Sample of Two Year Olds with an Autism Spectrum Disorder / E. MOULTON in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
PermalinkAn Association Study of Gamma-Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders / P. ADAK in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
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