Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica / Mohammad Hossein RAHBAR in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Titre : Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur Année de publication : 2012 Article en page(s) : p.1928-1938 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica [Texte imprimé et/ou numérique] / Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur . - 2012 . - p.1928-1938. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938 Mots-clés : Autism spectrum disorders  Maternal age  Paternal age  Multivariate General Linear Models  Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

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