[article] 
inJournal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.61-68

Titre :	Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Charlotte SKOGLUND, Auteur ; Qi CHEN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Paul LICHTENSTEIN, Auteur ; Henrik LARSSON, Auteur
Article en page(s) :	p.61-68
Langues :	Anglais (eng)
Mots-clés :	Maternal smoking during pregnancy  attention-deficit/hyperactivity disorder  confounding  sibling comparisons
Index. décimale :	PER Périodiques
Résumé :	Background Maternal Smoking During Pregnancy (SDP) has consistently been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but recent studies indicate that this association might be due to unmeasured familial confounding. Methods A total of 813,030 individuals born in Sweden between 1992 and 2000 were included in this nationwide population-based cohort study. Data on maternal SDP and ADHD diagnosis were obtained from national registers and patients were followed up from the age of 3 to the end of 2009. Hazard Ratios (HRs) were estimated using stratified Cox regression models. Cousin and sibling data were used to control for unmeasured familial confounding. Results At the population level maternal SDP predicted ADHD in offspring (HRModerateSDP = 1.89; HRHighSDP = 2.50). This estimate gradually attenuated toward the null when adjusting for measured confounders (HRModerateSDP = 1.62; HRHighSDP = 2.04), unmeasured confounders shared within the extended family (i.e., cousin comparison) (HRModerateSDP = 1.45; HRHighSDP = 1.69), and unmeasured confounders within the nuclear family (i.e., sibling comparison) (HRModerateSDP = 0.88; HRHighSDP = 0.84). Conclusions Our results suggest that the association between maternal SDP and offspring ADHD are due to unmeasured familial confounding.
En ligne :	http://dx.doi.org/10.1111/jcpp.12124
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

[article] Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring [Texte imprimé et/ou numérique] / Charlotte SKOGLUND, Auteur ; Qi CHEN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Paul LICHTENSTEIN, Auteur ; Henrik LARSSON, Auteur . - p.61-68.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.61-68

Mots-clés :	Maternal smoking during pregnancy  attention-deficit/hyperactivity disorder  confounding  sibling comparisons
Index. décimale :	PER Périodiques
Résumé :	Background Maternal Smoking During Pregnancy (SDP) has consistently been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but recent studies indicate that this association might be due to unmeasured familial confounding. Methods A total of 813,030 individuals born in Sweden between 1992 and 2000 were included in this nationwide population-based cohort study. Data on maternal SDP and ADHD diagnosis were obtained from national registers and patients were followed up from the age of 3 to the end of 2009. Hazard Ratios (HRs) were estimated using stratified Cox regression models. Cousin and sibling data were used to control for unmeasured familial confounding. Results At the population level maternal SDP predicted ADHD in offspring (HRModerateSDP = 1.89; HRHighSDP = 2.50). This estimate gradually attenuated toward the null when adjusting for measured confounders (HRModerateSDP = 1.62; HRHighSDP = 2.04), unmeasured confounders shared within the extended family (i.e., cousin comparison) (HRModerateSDP = 1.45; HRHighSDP = 1.69), and unmeasured confounders within the nuclear family (i.e., sibling comparison) (HRModerateSDP = 0.88; HRHighSDP = 0.84). Conclusions Our results suggest that the association between maternal SDP and offspring ADHD are due to unmeasured familial confounding.
En ligne :	http://dx.doi.org/10.1111/jcpp.12124
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220