Dépouillements

Black Autistic Lives Matter / Victoria ADEWALE in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 3 p. Titre : Black Autistic Lives Matter Type de document : Texte imprimé et/ou numérique Auteurs : Victoria ADEWALE, Auteur Article en page(s) : 3 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Black Autistic Lives Matter [Texte imprimé et/ou numérique] / Victoria ADEWALE, Auteur . - 3 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 3 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Exercise Alleviates Autism Spectrum Disorder Deficits / Trevor ARCHE in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 3 p. Titre : Exercise Alleviates Autism Spectrum Disorder Deficits Type de document : Texte imprimé et/ou numérique Auteurs : Trevor ARCHE, Auteur Article en page(s) : 3 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Exercise Alleviates Autism Spectrum Disorder Deficits [Texte imprimé et/ou numérique] / Trevor ARCHE, Auteur . - 3 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 3 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000146 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Bridging the Gap between Genes and Behavior: Brain-Derived Neurotrophic Factor and the mTOR Pathway in Idiopathic Autism / Margaret FAHNESTOCK in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 10 p. Titre : Bridging the Gap between Genes and Behavior: Brain-Derived Neurotrophic Factor and the mTOR Pathway in Idiopathic Autism Type de document : Texte imprimé et/ou numérique Auteurs : Margaret FAHNESTOCK, Auteur ; Chiara NICOLINI, Auteur Article en page(s) : 10 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although autism is highly genetic, “idiopathic” cases, for which there is no known genetic basis, may be due to epigenetic or environmental factors. Indeed, recent efforts have been highly successful in identifying hundreds of genes, as well as interacting epigenetic and environmental factors that contribute to autism susceptibility, corroborating the importance of gene x environment interactions in the etiology of autism. Nevertheless, a more thorough understanding of the proteins and pathways that lead from genes to behavior is desperately needed. Genetic studies have implicated molecules involved in synapse development and plasticity in autism pathogenesis. Among these are brain-derived neurotrophic factor (BDNF), its receptor, tropomyosin-related kinase B(TrkB), and their signaling pathways including mammalian target of rapamycin (mTOR), which is increased in most forms of syndromic autism. Notably, abnormalities in these molecules have also been found in idiopathic autism. Postmortem brain tissue of subjects with idiopathic autism exhibits imbalances in BDNF isoforms, reduced TrkB and downstream effectors PI3 kinase (PI3K), mTOR, Epidermal growth factor receptor pathway substrate 8 (Eps8) and the excitatory synaptic marker postsynaptic density protein 95 kDa (PSD-95). Furthermore, similar TrkB pathway deficits including reduced TrkB/mTOR signaling and PSD-95, along with autistic-like behavior, have been found in valproic acid-exposed rodents, a model of environmental/epigenetic causes of autism. Our studies in both human idiopathic autism and the valproic acid-induced rodent model suggest that decreased signaling through the mTOR pathway can be as damaging as its over-activation. En ligne : https://dx.doi.org/10.4172/2165-7890.1000143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Bridging the Gap between Genes and Behavior: Brain-Derived Neurotrophic Factor and the mTOR Pathway in Idiopathic Autism [Texte imprimé et/ou numérique] / Margaret FAHNESTOCK, Auteur ; Chiara NICOLINI, Auteur . - 10 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 10 p. Index. décimale : PER Périodiques Résumé : Although autism is highly genetic, “idiopathic” cases, for which there is no known genetic basis, may be due to epigenetic or environmental factors. Indeed, recent efforts have been highly successful in identifying hundreds of genes, as well as interacting epigenetic and environmental factors that contribute to autism susceptibility, corroborating the importance of gene x environment interactions in the etiology of autism. Nevertheless, a more thorough understanding of the proteins and pathways that lead from genes to behavior is desperately needed. Genetic studies have implicated molecules involved in synapse development and plasticity in autism pathogenesis. Among these are brain-derived neurotrophic factor (BDNF), its receptor, tropomyosin-related kinase B(TrkB), and their signaling pathways including mammalian target of rapamycin (mTOR), which is increased in most forms of syndromic autism. Notably, abnormalities in these molecules have also been found in idiopathic autism. Postmortem brain tissue of subjects with idiopathic autism exhibits imbalances in BDNF isoforms, reduced TrkB and downstream effectors PI3 kinase (PI3K), mTOR, Epidermal growth factor receptor pathway substrate 8 (Eps8) and the excitatory synaptic marker postsynaptic density protein 95 kDa (PSD-95). Furthermore, similar TrkB pathway deficits including reduced TrkB/mTOR signaling and PSD-95, along with autistic-like behavior, have been found in valproic acid-exposed rodents, a model of environmental/epigenetic causes of autism. Our studies in both human idiopathic autism and the valproic acid-induced rodent model suggest that decreased signaling through the mTOR pathway can be as damaging as its over-activation. En ligne : https://dx.doi.org/10.4172/2165-7890.1000143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

GABR genes, Autism Spectrum Disorder, and Epilepsy / Ciria C. HERNANDEZ in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 2 p. Titre : GABR genes, Autism Spectrum Disorder, and Epilepsy Type de document : Texte imprimé et/ou numérique Auteurs : Ciria C. HERNANDEZ, Auteur ; Luis E. GIMENEZ, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] GABR genes, Autism Spectrum Disorder, and Epilepsy [Texte imprimé et/ou numérique] / Ciria C. HERNANDEZ, Auteur ; Luis E. GIMENEZ, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Serum of Mothers Having Autistic Children Induces Cerebellar Purkinje cell Alterations in Experimental Model: A Possible Cause of Autism / Silva G. KOURTIAN in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 7 p. Titre : Serum of Mothers Having Autistic Children Induces Cerebellar Purkinje cell Alterations in Experimental Model: A Possible Cause of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Silva G. KOURTIAN, Auteur ; Nabila E. ABDELMEGUID, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism  Purkinje neurons  Plasma cells  Rattus Norvegicus Index. décimale : PER Périodiques Résumé : Autism is a brain developmental disorder characterized by impaired social interaction. Our aim is to assess the morphology of plasma cells of mothers having autistic children and to evaluate the effect of administration of serum obtained from mothers having autistic children on the cerebellar Purkinje neurons. Two groups were used: control group, where pregnant rats remained intact while others were injected intraperitoneally with serum of mothers with no history of autism. In the experimental group pregnant rats were intraperitoneally injected serum of autistic children's mothers. The Transmission Electron Microscope showed altered plasma cells of autistic children's mothers, where the heterochromatin material had inversed distribution in all nuclei examined in addition to other alterations. Also, modified Purkinje neurons were obtained in neonates of experimental group showing degeneration and atrophied dendrites. Recommended examination of peripheral blood is essential for early intervention. En ligne : https://dx.doi.org/10.4172/2165-7890.1000142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Serum of Mothers Having Autistic Children Induces Cerebellar Purkinje cell Alterations in Experimental Model: A Possible Cause of Autism [Texte imprimé et/ou numérique] / Silva G. KOURTIAN, Auteur ; Nabila E. ABDELMEGUID, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 7 p. Mots-clés : Autism  Purkinje neurons  Plasma cells  Rattus Norvegicus Index. décimale : PER Périodiques Résumé : Autism is a brain developmental disorder characterized by impaired social interaction. Our aim is to assess the morphology of plasma cells of mothers having autistic children and to evaluate the effect of administration of serum obtained from mothers having autistic children on the cerebellar Purkinje neurons. Two groups were used: control group, where pregnant rats remained intact while others were injected intraperitoneally with serum of mothers with no history of autism. In the experimental group pregnant rats were intraperitoneally injected serum of autistic children's mothers. The Transmission Electron Microscope showed altered plasma cells of autistic children's mothers, where the heterochromatin material had inversed distribution in all nuclei examined in addition to other alterations. Also, modified Purkinje neurons were obtained in neonates of experimental group showing degeneration and atrophied dendrites. Recommended examination of peripheral blood is essential for early intervention. En ligne : https://dx.doi.org/10.4172/2165-7890.1000142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

The Miller Umwelt Assessment Scale: A Tool for Planning Interventions for Children on the Autism Spectrum / Sonia MASTRANGELO in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 8 p. Titre : The Miller Umwelt Assessment Scale: A Tool for Planning Interventions for Children on the Autism Spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Sonia MASTRANGELO, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Neurological dysfunction  Cognitive-developmental system Index. décimale : PER Périodiques Résumé : The Miller Umwelt Assessment Scale is a useful tool for obtaining information about the developmental capacities of children on the autism spectrum. The assessment, made up of 19 tasks in the areas of: body organization, contact with surroundings, expressive and receptive communication, representation, and social-emotional development, has been used with much success over the past 40 years. While many assessments are difficult to administer to children on the autism spectrum, the simplicity of the MUAS reveals key strengths and challenges for both low and high functioning children on the spectrum. The results guide parents and clinicians in providing a curriculum and/or home program that moves children up the developmental ladder. En ligne : https://dx.doi.org/10.4172/2165-7890.1000140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] The Miller Umwelt Assessment Scale: A Tool for Planning Interventions for Children on the Autism Spectrum [Texte imprimé et/ou numérique] / Sonia MASTRANGELO, Auteur . - 8 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 8 p. Mots-clés : Autism spectrum disorder  Neurological dysfunction  Cognitive-developmental system Index. décimale : PER Périodiques Résumé : The Miller Umwelt Assessment Scale is a useful tool for obtaining information about the developmental capacities of children on the autism spectrum. The assessment, made up of 19 tasks in the areas of: body organization, contact with surroundings, expressive and receptive communication, representation, and social-emotional development, has been used with much success over the past 40 years. While many assessments are difficult to administer to children on the autism spectrum, the simplicity of the MUAS reveals key strengths and challenges for both low and high functioning children on the spectrum. The results guide parents and clinicians in providing a curriculum and/or home program that moves children up the developmental ladder. En ligne : https://dx.doi.org/10.4172/2165-7890.1000140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Mirtazapine-Galantamine Combo? Tackles Behavioral Facets in Autism / Ahmed NAGUY in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 2 p. Titre : Mirtazapine-Galantamine Combo? Tackles Behavioral Facets in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Ahmed NAGUY, Auteur ; Ali AL TAJALI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism; Challenging; Behaviors; Mirtazapine; Galantamine En ligne : https://dx.doi.org/10.4172/2165-7890.1000145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Mirtazapine-Galantamine Combo? Tackles Behavioral Facets in Autism [Texte imprimé et/ou numérique] / Ahmed NAGUY, Auteur ; Ali AL TAJALI, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 2 p. Index. décimale : PER Périodiques Résumé : Autism; Challenging; Behaviors; Mirtazapine; Galantamine En ligne : https://dx.doi.org/10.4172/2165-7890.1000145 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

The Science behind the Absence of Autism in the Amish Community: Energetic Immunity / Kandaswamy RAJALAKSHMI in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 2 p. Titre : The Science behind the Absence of Autism in the Amish Community: Energetic Immunity Type de document : Texte imprimé et/ou numérique Auteurs : Kandaswamy RAJALAKSHMI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] The Science behind the Absence of Autism in the Amish Community: Energetic Immunity [Texte imprimé et/ou numérique] / Kandaswamy RAJALAKSHMI, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

The Emerging Revolution In Autism: Re-Alignment of Energies and Being One’s Own Authority in Autism Healing / Kandaswamy RAJALAKSHMI in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 2 p. Titre : The Emerging Revolution In Autism: Re-Alignment of Energies and Being One’s Own Authority in Autism Healing Type de document : Texte imprimé et/ou numérique Auteurs : Kandaswamy RAJALAKSHMI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] The Emerging Revolution In Autism: Re-Alignment of Energies and Being One’s Own Authority in Autism Healing [Texte imprimé et/ou numérique] / Kandaswamy RAJALAKSHMI, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Autism: New Understanding of the Symptoms Through Discoveries Made in Psychoneuroimmunology / Kandaswamy RAJALAKSHMI in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 2 p. Titre : Autism: New Understanding of the Symptoms Through Discoveries Made in Psychoneuroimmunology Type de document : Texte imprimé et/ou numérique Auteurs : Kandaswamy RAJALAKSHMI, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Autism: New Understanding of the Symptoms Through Discoveries Made in Psychoneuroimmunology [Texte imprimé et/ou numérique] / Kandaswamy RAJALAKSHMI, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

A New Opportunity for Autism: The First Specific Italian Law / Dario SINISCALCO in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 1 p. Titre : A New Opportunity for Autism: The First Specific Italian Law Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Giovanna GALLONE, Auteur Article en page(s) : 1 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] A New Opportunity for Autism: The First Specific Italian Law [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Giovanna GALLONE, Auteur . - 1 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 1 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Mitochondria, Microbiome and Their Potential Psychiatric Modulation / Christopher SNYDER in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 4 p. Titre : Mitochondria, Microbiome and Their Potential Psychiatric Modulation Type de document : Texte imprimé et/ou numérique Auteurs : Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Mitochondria, Microbiome and Their Potential Psychiatric Modulation [Texte imprimé et/ou numérique] / Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 4 p. Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409