[article] 
inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882

Titre :	Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur
Année de publication :	2014
Article en page(s) :	p.873-882
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter
Index. décimale :	PER Périodiques
Résumé :	Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology.
En ligne :	http://dx.doi.org/10.1007/s10803-013-1939-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

[article] Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Leonardo EMBERTI GIALLORETI, Auteur ; Matteo PARDINI, Auteur ; Francesca BENASSI, Auteur ; Sara MARCIANO, Auteur ; Mario AMORE, Auteur ; Maria Giulia MUTOLO, Auteur ; Maria Cristina PORFIRIO, Auteur ; Paolo CURATOLO, Auteur . - 2014 . - p.873-882.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.873-882

Mots-clés :	Autism spectrum disorders  Retinal nerve fiber layer thickness  Optical coherence tomography (OCT)  White matter
Index. décimale :	PER Périodiques
Résumé :	Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology.
En ligne :	http://dx.doi.org/10.1007/s10803-013-1939-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228