Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders / Natacha AKSHOOMOFF in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.887-893 Titre : Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Natacha AKSHOOMOFF, Auteur ; Nikdokht FARID, Auteur ; Eric COURCHESNE, Auteur ; Richard HAAS, Auteur Année de publication : 2007 Article en page(s) : p.887-893 Langues : Anglais (eng) Mots-clés : Neurology Seizures EEG Index. décimale : PER Périodiques Résumé : This study examined the nature and frequency of neurological and EEG abnormalities in 60 young children (ages 2–6 years) with pervasive developmental disorders. A number of standard neurological functions could not be adequately assessed due to the young age of the children and/or limited comprehension and cooperation. The most common neurological deficits were hyporeflexia, stereotypies, and hypotonia. EEG abnormalities were identified in 32% of the children while only two children were known to have clinical seizures. The frequency of cases with hypotonia or hyporeflexia was more common than in older children with this diagnosis. Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0216-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 [article] Abnormalities on the Neurological Examination and EEG in Young Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Natacha AKSHOOMOFF, Auteur ; Nikdokht FARID, Auteur ; Eric COURCHESNE, Auteur ; Richard HAAS, Auteur . - 2007 . - p.887-893. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.887-893 Mots-clés : Neurology Seizures EEG Index. décimale : PER Périodiques Résumé : This study examined the nature and frequency of neurological and EEG abnormalities in 60 young children (ages 2–6 years) with pervasive developmental disorders. A number of standard neurological functions could not be adequately assessed due to the young age of the children and/or limited comprehension and cooperation. The most common neurological deficits were hyporeflexia, stereotypies, and hypotonia. EEG abnormalities were identified in 32% of the children while only two children were known to have clinical seizures. The frequency of cases with hypotonia or hyporeflexia was more common than in older children with this diagnosis. Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0216-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey / Robert T. SCHULTZ in Autism, 12-3 (May 2008)  

Public ISBD [article]  inAutism > 12-3 (May 2008) . - p.293-307 Titre : Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey Type de document : Texte imprimé et/ou numérique Auteurs : Robert T. SCHULTZ, Auteur ; Natacha AKSHOOMOFF, Auteur ; Hillary S. KLONOFF-COHEN, Auteur ; Deborah L. WINGARD, Auteur ; Caroline A. MACERA, Auteur ; Ming JI, Auteur Année de publication : 2008 Article en page(s) : p.293-307 Langues : Anglais (eng) Mots-clés : acetaminophen autism paracetamol vaccination Index. décimale : PER Périodiques Résumé : The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder. This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42—26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11—14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56—43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder. En ligne : http://dx.doi.org/10.1177/1362361307089518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=424 [article] Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey [Texte imprimé et/ou numérique] / Robert T. SCHULTZ, Auteur ; Natacha AKSHOOMOFF, Auteur ; Hillary S. KLONOFF-COHEN, Auteur ; Deborah L. WINGARD, Auteur ; Caroline A. MACERA, Auteur ; Ming JI, Auteur . - 2008 . - p.293-307. Langues : Anglais (eng) in Autism > 12-3 (May 2008) . - p.293-307 Mots-clés : acetaminophen autism paracetamol vaccination Index. décimale : PER Périodiques Résumé : The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder. This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42—26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11—14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56—43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder. En ligne : http://dx.doi.org/10.1177/1362361307089518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=424

Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders / Lauren CORNEW in Journal of Autism and Developmental Disorders, 42-12 (December 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2611-2621 Titre : Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lauren CORNEW, Auteur ; Karen R. DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Joseph P. MCCLEERY, Auteur ; Leslie J. CARVER, Auteur Année de publication : 2012 Article en page(s) : p.2611-2621 Langues : Anglais (eng) Mots-clés : Autism  Social referencing  Joint attention  Behavior regulation Index. décimale : PER Périodiques Résumé : Social referencing was investigated in 18-month-old siblings of children with autism spectrum disorders (ASD; 'high-risk infants'). Infants were exposed to novel toys, which were emotionally tagged via adults' facial and vocal signals. Infants' information seeking (initiation of joint attention with an adult) and their approach/withdrawal behavior toward the toys before versus after the adults' emotional signals was measured. Compared to both typically developing infants and high-risk infants without ASD, infants later diagnosed with ASD engaged in slower information seeking, suggesting that this aspect of referencing may be an early indicator of ASD. High-risk infants, both those who were and those who were not later diagnosed with ASD, exhibited impairments in regulating their behavior based on the adults' emotional signals, suggesting that this aspect of social referencing may reflect an endophenotype for ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1518-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184 [article] Atypical Social Referencing in Infant Siblings of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lauren CORNEW, Auteur ; Karen R. DOBKINS, Auteur ; Natacha AKSHOOMOFF, Auteur ; Joseph P. MCCLEERY, Auteur ; Leslie J. CARVER, Auteur . - 2012 . - p.2611-2621. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-12 (December 2012) . - p.2611-2621 Mots-clés : Autism  Social referencing  Joint attention  Behavior regulation Index. décimale : PER Périodiques Résumé : Social referencing was investigated in 18-month-old siblings of children with autism spectrum disorders (ASD; 'high-risk infants'). Infants were exposed to novel toys, which were emotionally tagged via adults' facial and vocal signals. Infants' information seeking (initiation of joint attention with an adult) and their approach/withdrawal behavior toward the toys before versus after the adults' emotional signals was measured. Compared to both typically developing infants and high-risk infants without ASD, infants later diagnosed with ASD engaged in slower information seeking, suggesting that this aspect of referencing may be an early indicator of ASD. High-risk infants, both those who were and those who were not later diagnosed with ASD, exhibited impairments in regulating their behavior based on the adults' emotional signals, suggesting that this aspect of social referencing may reflect an endophenotype for ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1518-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=184

Diagnosis of autism spectrum disorders in 2-year-olds: a study of community practice / Christina M. CORSELLO in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.178-185 Titre : Diagnosis of autism spectrum disorders in 2-year-olds: a study of community practice Type de document : Texte imprimé et/ou numérique Auteurs : Christina M. CORSELLO, Auteur ; Natacha AKSHOOMOFF, Auteur ; Aubyn C. STAHMER, Auteur Année de publication : 2013 Article en page(s) : p.178-185 Langues : Anglais (eng) Mots-clés : Autism  diagnosis  services research Index. décimale : PER Périodiques Résumé : Background: Longitudinal research studies have demonstrated that experienced clinicians using standardized assessment measures can make a reliable diagnosis of autism spectrum disorders (ASDs) in children under age 3. Limited data are available regarding the sensitivity and specificity of these measures in community settings. The aims of this study were to determine how well a standardized diagnostic observational measure (Autism Diagnostic Observation Schedule – ADOS) functions alone, and with a brief parent measure within a community setting when administered by community clinicians. Methods: Clinical records for 138 children between the ages of 24 and 36 months of age who were evaluated for possible ASD or social/language concerns at a hospital-based developmental evaluation clinic were examined. Evaluations were conducted by community-based clinical psychologists. Classification results obtained from standardized diagnostic measures were compared with case reviewer diagnosis, by reviewers blind to scores on diagnostic measures, using The Records-based Methodology for ASD Case Definition that was developed by the Metropolitan Atlanta Developmental Disabilities Surveillance Program. Results: When compared with case review diagnosis, the ADOS demonstrated strong sensitivity and specificity for both Autism versus Not Autism and ASD versus Nonspectrum (NS) diagnoses in this young sample. The Social Communication Questionnaire (SCQ), using the lower cutoff of ?12, had adequate sensitivity when differentiating Autism from Not Autism, but weak sensitivity when differentiating ASD from NS, missing about 80% of the children with pervasive developmental disorder – not otherwise specified. Using either the Modified Checklist for Autism in Toddlers or the SCQ in combination with the ADOS did not result in improved specificity over the ADOS alone and led to a drop in sensitivity when differentiating ASD from NS disorders. Conclusions: These results demonstrate that following best practice guidelines, the ADOS can be successfully incorporated into clinical practice with relatively good sensitivity and specificity, and worked well with a referred sample of 2-year-olds. A parent questionnaire did not lead to any improvement in diagnostic classification above the ADOS used in isolation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02607.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Diagnosis of autism spectrum disorders in 2-year-olds: a study of community practice [Texte imprimé et/ou numérique] / Christina M. CORSELLO, Auteur ; Natacha AKSHOOMOFF, Auteur ; Aubyn C. STAHMER, Auteur . - 2013 . - p.178-185. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.178-185 Mots-clés : Autism  diagnosis  services research Index. décimale : PER Périodiques Résumé : Background: Longitudinal research studies have demonstrated that experienced clinicians using standardized assessment measures can make a reliable diagnosis of autism spectrum disorders (ASDs) in children under age 3. Limited data are available regarding the sensitivity and specificity of these measures in community settings. The aims of this study were to determine how well a standardized diagnostic observational measure (Autism Diagnostic Observation Schedule – ADOS) functions alone, and with a brief parent measure within a community setting when administered by community clinicians. Methods: Clinical records for 138 children between the ages of 24 and 36 months of age who were evaluated for possible ASD or social/language concerns at a hospital-based developmental evaluation clinic were examined. Evaluations were conducted by community-based clinical psychologists. Classification results obtained from standardized diagnostic measures were compared with case reviewer diagnosis, by reviewers blind to scores on diagnostic measures, using The Records-based Methodology for ASD Case Definition that was developed by the Metropolitan Atlanta Developmental Disabilities Surveillance Program. Results: When compared with case review diagnosis, the ADOS demonstrated strong sensitivity and specificity for both Autism versus Not Autism and ASD versus Nonspectrum (NS) diagnoses in this young sample. The Social Communication Questionnaire (SCQ), using the lower cutoff of ?12, had adequate sensitivity when differentiating Autism from Not Autism, but weak sensitivity when differentiating ASD from NS, missing about 80% of the children with pervasive developmental disorder – not otherwise specified. Using either the Modified Checklist for Autism in Toddlers or the SCQ in combination with the ADOS did not result in improved specificity over the ADOS alone and led to a drop in sensitivity when differentiating ASD from NS disorders. Conclusions: These results demonstrate that following best practice guidelines, the ADOS can be successfully incorporated into clinical practice with relatively good sensitivity and specificity, and worked well with a referred sample of 2-year-olds. A parent questionnaire did not lead to any improvement in diagnostic classification above the ADOS used in isolation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02607.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

Inclusion for toddlers with autism spectrum disorders: The first ten years of a community program / Aubyn C. STAHMER in Autism, 15-5 (September 2011)  

Public ISBD [article]  inAutism > 15-5 (September 2011) . - p.625-641 Titre : Inclusion for toddlers with autism spectrum disorders: The first ten years of a community program Type de document : Texte imprimé et/ou numérique Auteurs : Aubyn C. STAHMER, Auteur ; Natacha AKSHOOMOFF, Auteur ; Allison B. CUNNINGHAM, Auteur Année de publication : 2011 Article en page(s) : p.625-641 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  community program  early intervention Index. décimale : PER Périodiques Résumé : The present quasi-experimental study examines the outcomes for a group of 102 children diagnosed with an autism spectrum disorder at age 2 who attended an inclusive toddler program (described by Stahmer and Ingersoll, 2004) until age 3. Outcomes on standardized developmental assessments indicate significant improvement, with large effect sizes, in developmental level, adaptive behavior and communication. Thirty-one of the children (31%) were functioning in the typically developing range when they exited the program at age 3, after an average of 8 months of intervention. Predictors of positive outcomes included length of time in the program, level of words and gestures use at entry and higher externalizing and lower internalizing behavior CBCL scores at entry. Implications for serving toddlers with autism in inclusive settings and suggestions for future research directions are discussed. En ligne : http://dx.doi.org/10.1177/1362361310392253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144 [article] Inclusion for toddlers with autism spectrum disorders: The first ten years of a community program [Texte imprimé et/ou numérique] / Aubyn C. STAHMER, Auteur ; Natacha AKSHOOMOFF, Auteur ; Allison B. CUNNINGHAM, Auteur . - 2011 . - p.625-641. Langues : Anglais (eng) in Autism > 15-5 (September 2011) . - p.625-641 Mots-clés : autism spectrum disorders  community program  early intervention Index. décimale : PER Périodiques Résumé : The present quasi-experimental study examines the outcomes for a group of 102 children diagnosed with an autism spectrum disorder at age 2 who attended an inclusive toddler program (described by Stahmer and Ingersoll, 2004) until age 3. Outcomes on standardized developmental assessments indicate significant improvement, with large effect sizes, in developmental level, adaptive behavior and communication. Thirty-one of the children (31%) were functioning in the typically developing range when they exited the program at age 3, after an average of 8 months of intervention. Predictors of positive outcomes included length of time in the program, level of words and gestures use at entry and higher externalizing and lower internalizing behavior CBCL scores at entry. Implications for serving toddlers with autism in inclusive settings and suggestions for future research directions are discussed. En ligne : http://dx.doi.org/10.1177/1362361310392253 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144

Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder / DeWayne C. LAZENBY in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

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A pilot study examining the use of the autism diagnostic observation schedule in community-based mental health clinics / Nicole STADNICK in Research in Autism Spectrum Disorders, 20 (December 2015)  

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