[3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study / Jeffrey T. GUPTILL in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Titre : [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur Année de publication : 2007 Article en page(s) : p.911-920 Langues : Anglais (eng) Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 [article] [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study [Texte imprimé et/ou numérique] / Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur . - 2007 . - p.911-920. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism / Adrian L. OBLAK in Autism Research, 2-4 (August 2009)  

Public ISBD [article]  inAutism Research > 2-4 (August 2009) . - p.205-219 Titre : Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism Type de document : Texte imprimé et/ou numérique Auteurs : Adrian L. OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur Année de publication : 2009 Article en page(s) : p.205-219 Langues : Anglais (eng) Mots-clés : autistic anterior-cingulate-cortex GABA post-mortem ligand-binding Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affected in autism. The benzodiazepine binding site on the GABAA receptor complex is an important target for pharmacotherapy and has important clinical implications. The present multiple-concentration ligand-binding study utilized 3H-muscimol and 3H-flunitrazepam to determine the number (Bmax), binding affinity (Kd), and distribution of GABAA receptors and benzodiazepine binding sites, respectively, in the ACC in adult autistic and control cases. Compared to controls, the autistic group had significant decreases in the mean density of GABAA receptors in the supragranular (46.8%) and infragranular (20.2%) layers of the ACC and in the density of benzodiazepine binding sites in the supragranular (28.9%) and infragranular (16.4%) lamina. In addition, a trend for a decrease in for the density of benzodiazepine sites was found in the infragranular layers (17.1%) in the autism group. These findings suggest that in the autistic group this downregulation of both benzodiazepine sites and GABAA receptors in the ACC may be the result of increased GABA innervation and/or release disturbing the delicate excitation/inhibition balance of principal neurons as well as their output to key limbic cortical targets. Such disturbances likely underlie the core alterations in socio-emotional behaviors in autism. En ligne : http://dx.doi.org/10.1002/aur.88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937 [article] Decreased GABA A receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism [Texte imprimé et/ou numérique] / Adrian L. OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur . - 2009 . - p.205-219. Langues : Anglais (eng) in Autism Research > 2-4 (August 2009) . - p.205-219 Mots-clés : autistic anterior-cingulate-cortex GABA post-mortem ligand-binding Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affected in autism. The benzodiazepine binding site on the GABAA receptor complex is an important target for pharmacotherapy and has important clinical implications. The present multiple-concentration ligand-binding study utilized 3H-muscimol and 3H-flunitrazepam to determine the number (Bmax), binding affinity (Kd), and distribution of GABAA receptors and benzodiazepine binding sites, respectively, in the ACC in adult autistic and control cases. Compared to controls, the autistic group had significant decreases in the mean density of GABAA receptors in the supragranular (46.8%) and infragranular (20.2%) layers of the ACC and in the density of benzodiazepine binding sites in the supragranular (28.9%) and infragranular (16.4%) lamina. In addition, a trend for a decrease in for the density of benzodiazepine sites was found in the infragranular layers (17.1%) in the autism group. These findings suggest that in the autistic group this downregulation of both benzodiazepine sites and GABAA receptors in the ACC may be the result of increased GABA innervation and/or release disturbing the delicate excitation/inhibition balance of principal neurons as well as their output to key limbic cortical targets. Such disturbances likely underlie the core alterations in socio-emotional behaviors in autism. En ligne : http://dx.doi.org/10.1002/aur.88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=937

Pharmacological Treatment of Autism / Terrell T. GIBBS

Public ISBD contenu dans The Neurochemical Basis of Autism / Gene J. BLATT Titre : Pharmacological Treatment of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Terrell T. GIBBS, Auteur Année de publication : 2010 Importance : p.245-267 Langues : Anglais (eng) Mots-clés : Secrétine  Antipsychotique  Anticonvulsif  Melatonine  Naltrexone  Antagoniste des récepteurs Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 contenu dans The Neurochemical Basis of Autism / Gene J. BLATT Pharmacological Treatment of Autism [Texte imprimé et/ou numérique] / Terrell T. GIBBS, Auteur . - 2010 . - p.245-267. Langues : Anglais (eng) Mots-clés : Secrétine  Antipsychotique  Anticonvulsif  Melatonine  Naltrexone  Antagoniste des récepteurs Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109

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Reduced Serotonin Receptor Subtypes in a Limbic and a Neocortical Region in Autism / Adrian OBLAK in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.571-583 Titre : Reduced Serotonin Receptor Subtypes in a Limbic and a Neocortical Region in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Adrian OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur Année de publication : 2013 Article en page(s) : p.571-583 Langues : Anglais (eng) Mots-clés : autism  serotonin  5-HT1A receptors  5-HT2A receptors  5-HT transporters  pharmacotherapy  selective serotonin reuptake inhibitors (SSRI) Index. décimale : PER Périodiques Résumé : Autism is a behaviorally defined, neurological disorder with symptom onset before the age of 3. Abnormalities in social-emotional behaviors are a core deficit in autism, and are characterized by impaired reciprocal–social interaction, lack of facial expressions, and the inability to recognize familiar faces. The posterior cingulate cortex (PCC) and fusiform gyrus (FG) are two regions within an extensive limbic-cortical network that contribute to social-emotional behaviors. Evidence indicates that changes in brains of individuals with autism begin prenatally. Serotonin (5-HT) is one of the earliest expressed neurotransmitters, and plays an important role in synaptogenesis, neurite outgrowth, and neuronal migration. Abnormalities in 5-HT systems have been implicated in several psychiatric disorders, including autism, as evidenced by immunology, imaging, genetics, pharmacotherapy, and neuropathology. Although information is known regarding peripheral 5-HT in autism, there is emerging evidence that 5-HT systems in the central nervous system, including various 5-HT receptor subtypes and transporters, are affected in autism. The present study demonstrated significant reductions in 5-HT1A receptor-binding density in superficial and deep layers of the PCC and FG, and in the density of 5-HT2A receptors in superficial layers of the PCC and FG. A significant reduction in the density of serotonin transporters (5-HTT) was also found in the deep layers of the FG, but normal levels were demonstrated in both layers of the PCC and superficial layers of the FG. This study provides potential substrates for decreased 5-HT modulation/innervation in the autism brain, and implicate two 5-HT receptor subtypes as potential neuromarkers for novel or existing pharmacotherapies. En ligne : http://dx.doi.org/10.1002/aur.1317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Reduced Serotonin Receptor Subtypes in a Limbic and a Neocortical Region in Autism [Texte imprimé et/ou numérique] / Adrian OBLAK, Auteur ; Terrell T. GIBBS, Auteur ; Gene J. BLATT, Auteur . - 2013 . - p.571-583. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.571-583 Mots-clés : autism  serotonin  5-HT1A receptors  5-HT2A receptors  5-HT transporters  pharmacotherapy  selective serotonin reuptake inhibitors (SSRI) Index. décimale : PER Périodiques Résumé : Autism is a behaviorally defined, neurological disorder with symptom onset before the age of 3. Abnormalities in social-emotional behaviors are a core deficit in autism, and are characterized by impaired reciprocal–social interaction, lack of facial expressions, and the inability to recognize familiar faces. The posterior cingulate cortex (PCC) and fusiform gyrus (FG) are two regions within an extensive limbic-cortical network that contribute to social-emotional behaviors. Evidence indicates that changes in brains of individuals with autism begin prenatally. Serotonin (5-HT) is one of the earliest expressed neurotransmitters, and plays an important role in synaptogenesis, neurite outgrowth, and neuronal migration. Abnormalities in 5-HT systems have been implicated in several psychiatric disorders, including autism, as evidenced by immunology, imaging, genetics, pharmacotherapy, and neuropathology. Although information is known regarding peripheral 5-HT in autism, there is emerging evidence that 5-HT systems in the central nervous system, including various 5-HT receptor subtypes and transporters, are affected in autism. The present study demonstrated significant reductions in 5-HT1A receptor-binding density in superficial and deep layers of the PCC and FG, and in the density of 5-HT2A receptors in superficial layers of the PCC and FG. A significant reduction in the density of serotonin transporters (5-HTT) was also found in the deep layers of the FG, but normal levels were demonstrated in both layers of the PCC and superficial layers of the FG. This study provides potential substrates for decreased 5-HT modulation/innervation in the autism brain, and implicate two 5-HT receptor subtypes as potential neuromarkers for novel or existing pharmacotherapies. En ligne : http://dx.doi.org/10.1002/aur.1317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

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