[article]
| Titre : |
The contribution of epigenetics to understanding genetic factors in autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Layla HALL, Auteur ; Elizabeth KELLEY, Auteur |
| Article en page(s) : |
p.872-881 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism autism spectrum disorder epigenetic genetic |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorder is a grouping of neurodevelopmental disorders characterized by deficits in social communication and language, as well as by repetitive and stereotyped behaviors. While the environment is believed to play a role in the development of autism spectrum disorder, there is now strong evidence for a genetic link to autism. Despite such evidence, studies investigating a potential single-gene cause for autism, although insightful, have been highly inconclusive. A consideration of an epigenetic approach proves to be very promising in clarifying genetic factors involved in autism. The present article is intended to provide a review of key findings pertaining to epigenetics in autism in such a way that a broader audience of individuals who do not have a strong background in genetics may better understand this highly specific and scientific content. Epigenetics refers to non-permanent heritable changes that alter expression of genes without altering the DNA sequence itself and considers the role of environment in this modulation of gene expression. This review provides a brief description of epigenetic processes, highlights evidence in the literature of epigenetic dysregulation in autism, and makes use of noteworthy findings to illustrate how a consideration of epigenetic factors can deepen our understanding of the development of autism. Furthermore, this discussion will present a promising new way for moving forward in the investigation of genetic factors within autism. |
| En ligne : |
http://dx.doi.org/10.1177/1362361313503501 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 |
in Autism > 18-8 (November 2014) . - p.872-881
[article] The contribution of epigenetics to understanding genetic factors in autism [Texte imprimé et/ou numérique] / Layla HALL, Auteur ; Elizabeth KELLEY, Auteur . - p.872-881. Langues : Anglais ( eng) in Autism > 18-8 (November 2014) . - p.872-881
| Mots-clés : |
autism autism spectrum disorder epigenetic genetic |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorder is a grouping of neurodevelopmental disorders characterized by deficits in social communication and language, as well as by repetitive and stereotyped behaviors. While the environment is believed to play a role in the development of autism spectrum disorder, there is now strong evidence for a genetic link to autism. Despite such evidence, studies investigating a potential single-gene cause for autism, although insightful, have been highly inconclusive. A consideration of an epigenetic approach proves to be very promising in clarifying genetic factors involved in autism. The present article is intended to provide a review of key findings pertaining to epigenetics in autism in such a way that a broader audience of individuals who do not have a strong background in genetics may better understand this highly specific and scientific content. Epigenetics refers to non-permanent heritable changes that alter expression of genes without altering the DNA sequence itself and considers the role of environment in this modulation of gene expression. This review provides a brief description of epigenetic processes, highlights evidence in the literature of epigenetic dysregulation in autism, and makes use of noteworthy findings to illustrate how a consideration of epigenetic factors can deepen our understanding of the development of autism. Furthermore, this discussion will present a promising new way for moving forward in the investigation of genetic factors within autism. |
| En ligne : |
http://dx.doi.org/10.1177/1362361313503501 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 |
|
The contribution of epigenetics to understanding genetic factors in autism in Autism, 18-8 (November 2014)
