[article]
| Titre : |
Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse |
| Type de document : |
texte imprimé |
| Auteurs : |
Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur |
| Article en page(s) : |
p.1372-1379 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
GABRA2 rule breaking substance abuse adolescence mediation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12244 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 |
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379
[article] Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse [texte imprimé] / Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur . - p.1372-1379. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379
| Mots-clés : |
GABRA2 rule breaking substance abuse adolescence mediation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12244 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 |
|  |
Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
