[article] 
inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379

Titre :	Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur
Article en page(s) :	p.1372-1379
Langues :	Anglais (eng)
Mots-clés :	GABRA2  rule breaking  substance abuse  adolescence  mediation
Index. décimale :	PER Périodiques
Résumé :	Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use.
En ligne :	http://dx.doi.org/10.1111/jcpp.12244
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

[article] Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse [Texte imprimé et/ou numérique] / Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur . - p.1372-1379.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379

Mots-clés :	GABRA2  rule breaking  substance abuse  adolescence  mediation
Index. décimale :	PER Périodiques
Résumé :	Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use.
En ligne :	http://dx.doi.org/10.1111/jcpp.12244
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243