Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors / N. M. FAVA in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Titre : Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors Type de document : Texte imprimé et/ou numérique Auteurs : N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur Article en page(s) : p.1439-1450 Langues : Anglais (eng) Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors [Texte imprimé et/ou numérique] / N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur . - p.1439-1450. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Incipient alcohol use in childhood: Early alcohol sipping and its relations with psychopathology and personality / Ashley L. WATTS in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1338-1350 Titre : Incipient alcohol use in childhood: Early alcohol sipping and its relations with psychopathology and personality Type de document : Texte imprimé et/ou numérique Auteurs : Ashley L. WATTS, Auteur ; Phillip K. WOOD, Auteur ; Kristina M. JACKSON, Auteur ; Krista M. LISDAHL, Auteur ; Mary M. HEITZEG, Auteur ; Raul GONZALEZ, Auteur ; Susan F. TAPERT, Auteur ; Deanna M. BARCH, Auteur ; Kenneth J. SHER, Auteur Article en page(s) : p.1338-1350 Langues : Anglais (eng) Mots-clés : alcohol sipping  novelty seeking  personality  precocious alcohol use  psychopathology Index. décimale : PER Périodiques Résumé : Prior research has shown that sipping of alcohol begins to emerge during childhood and is potentially etiologically significant for later substance use problems. Using a large, community sample of 9- and 10-year-olds (N = 11,872; 53% female), we examined individual differences in precocious alcohol use in the form of alcohol sipping. We focused explicitly on features that are robust and well-demonstrated correlates of, and antecedents to, alcohol excess and related problems later in the lifespan, including youth- and parent-reported externalizing traits (i.e., impulsivity, behavioral inhibition and activation) and psychopathology. Seventeen percent of the sample reported sipping alcohol outside of a religiously sanctioned activity by age 9 or 10. Several aspects of psychopathology and personality emerged as small but reliable correlates of sipping. Nonreligious sipping was related to youth-reported impulsigenic traits, aspects of behavioral activation, prodromal psychotic-like symptoms, and mood disorder diagnoses, as well as parent-reported externalizing disorder diagnoses. Religious sipping was unexpectedly associated with certain aspects of impulsivity. Together, our findings point to the potential importance of impulsivity and other transdiagnostic indicators of psychopathology (e.g., emotion dysregulation, novelty seeking) in the earliest forms of drinking behavior. En ligne : http://dx.doi.org/10.1017/S0954579420000541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Incipient alcohol use in childhood: Early alcohol sipping and its relations with psychopathology and personality [Texte imprimé et/ou numérique] / Ashley L. WATTS, Auteur ; Phillip K. WOOD, Auteur ; Kristina M. JACKSON, Auteur ; Krista M. LISDAHL, Auteur ; Mary M. HEITZEG, Auteur ; Raul GONZALEZ, Auteur ; Susan F. TAPERT, Auteur ; Deanna M. BARCH, Auteur ; Kenneth J. SHER, Auteur . - p.1338-1350. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1338-1350 Mots-clés : alcohol sipping  novelty seeking  personality  precocious alcohol use  psychopathology Index. décimale : PER Périodiques Résumé : Prior research has shown that sipping of alcohol begins to emerge during childhood and is potentially etiologically significant for later substance use problems. Using a large, community sample of 9- and 10-year-olds (N = 11,872; 53% female), we examined individual differences in precocious alcohol use in the form of alcohol sipping. We focused explicitly on features that are robust and well-demonstrated correlates of, and antecedents to, alcohol excess and related problems later in the lifespan, including youth- and parent-reported externalizing traits (i.e., impulsivity, behavioral inhibition and activation) and psychopathology. Seventeen percent of the sample reported sipping alcohol outside of a religiously sanctioned activity by age 9 or 10. Several aspects of psychopathology and personality emerged as small but reliable correlates of sipping. Nonreligious sipping was related to youth-reported impulsigenic traits, aspects of behavioral activation, prodromal psychotic-like symptoms, and mood disorder diagnoses, as well as parent-reported externalizing disorder diagnoses. Religious sipping was unexpectedly associated with certain aspects of impulsivity. Together, our findings point to the potential importance of impulsivity and other transdiagnostic indicators of psychopathology (e.g., emotion dysregulation, novelty seeking) in the earliest forms of drinking behavior. En ligne : http://dx.doi.org/10.1017/S0954579420000541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Incipient Alcohol Use in Childhood: Early Alcohol Sipping and its Relations with Psychopathology and Personality – Corrigendum / Ashley L. WATTS in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.1139-1139 Titre : Incipient Alcohol Use in Childhood: Early Alcohol Sipping and its Relations with Psychopathology and Personality – Corrigendum Type de document : Texte imprimé et/ou numérique Auteurs : Ashley L. WATTS, Auteur ; Phillip K. WOOD, Auteur ; Kristina M. JACKSON, Auteur ; Krista M. LISDAHL, Auteur ; Mary M. HEITZEG, Auteur ; Raul GONZALEZ, Auteur ; Susan F. TAPERT, Auteur ; Deanna M. BARCH, Auteur ; Kenneth J. SHER, Auteur Article en page(s) : p.1139-1139 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579420001170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Incipient Alcohol Use in Childhood: Early Alcohol Sipping and its Relations with Psychopathology and Personality – Corrigendum [Texte imprimé et/ou numérique] / Ashley L. WATTS, Auteur ; Phillip K. WOOD, Auteur ; Kristina M. JACKSON, Auteur ; Krista M. LISDAHL, Auteur ; Mary M. HEITZEG, Auteur ; Raul GONZALEZ, Auteur ; Susan F. TAPERT, Auteur ; Deanna M. BARCH, Auteur ; Kenneth J. SHER, Auteur . - p.1139-1139. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.1139-1139 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579420001170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse / Elisa M. TRUCCO in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379 Titre : Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse Type de document : Texte imprimé et/ou numérique Auteurs : Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur Article en page(s) : p.1372-1379 Langues : Anglais (eng) Mots-clés : GABRA2  rule breaking  substance abuse  adolescence  mediation Index. décimale : PER Périodiques Résumé : Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use. En ligne : http://dx.doi.org/10.1111/jcpp.12244 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse [Texte imprimé et/ou numérique] / Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur . - p.1372-1379. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1372-1379 Mots-clés : GABRA2  rule breaking  substance abuse  adolescence  mediation Index. décimale : PER Périodiques Résumé : Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11–18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use. En ligne : http://dx.doi.org/10.1111/jcpp.12244 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele / Elisa M. TRUCCO in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.15-26 Titre : Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele Type de document : Texte imprimé et/ou numérique Auteurs : Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur Article en page(s) : p.15-26 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Understanding factors increasing susceptibility to social contexts and predicting psychopathology can help identify targets for prevention. Persistently high externalizing behavior in adolescence is predictive of psychopathology in adulthood. Parental monitoring predicts low externalizing behavior, yet youth likely vary in the degree to which they are affected by parents. Genetic variants of GABA receptor subunit alpha-2 (GABRA2) may increase susceptibility to parental monitoring, thus impacting externalizing trajectories. We had several objectives: (a) to determine whether GABRA2 (rs279827, rs279826, rs279858) moderates the relationship between a component of parental monitoring, parental knowledge, and externalizing trajectories; (b) to test the form of this interaction to assess whether GABRA2 variants reflect risk (diathesis–stress) or susceptibility (differential susceptibility) factors; and (c) to clarify GABRA2 associations on the development of problem behavior. This prospective study (N = 504) identified three externalizing trajectory classes (i.e., low, decreasing, and high) across adolescence. A GABRA2 × Parental Monitoring effect on class membership was observed, such that A-carriers were largely unaffected by parental monitoring, whereas class membership for those with the GG genotype was affected by parental monitoring. Findings support differential susceptibility in GABRA2. En ligne : http://dx.doi.org/10.1017/S0954579415000255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele [Texte imprimé et/ou numérique] / Elisa M. TRUCCO, Auteur ; Sandra VILLAFUERTE, Auteur ; Mary M. HEITZEG, Auteur ; Margit BURMEISTER, Auteur ; Robert A. ZUCKER, Auteur . - p.15-26. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.15-26 Index. décimale : PER Périodiques Résumé : Understanding factors increasing susceptibility to social contexts and predicting psychopathology can help identify targets for prevention. Persistently high externalizing behavior in adolescence is predictive of psychopathology in adulthood. Parental monitoring predicts low externalizing behavior, yet youth likely vary in the degree to which they are affected by parents. Genetic variants of GABA receptor subunit alpha-2 (GABRA2) may increase susceptibility to parental monitoring, thus impacting externalizing trajectories. We had several objectives: (a) to determine whether GABRA2 (rs279827, rs279826, rs279858) moderates the relationship between a component of parental monitoring, parental knowledge, and externalizing trajectories; (b) to test the form of this interaction to assess whether GABRA2 variants reflect risk (diathesis–stress) or susceptibility (differential susceptibility) factors; and (c) to clarify GABRA2 associations on the development of problem behavior. This prospective study (N = 504) identified three externalizing trajectory classes (i.e., low, decreasing, and high) across adolescence. A GABRA2 × Parental Monitoring effect on class membership was observed, such that A-carriers were largely unaffected by parental monitoring, whereas class membership for those with the GG genotype was affected by parental monitoring. Findings support differential susceptibility in GABRA2. En ligne : http://dx.doi.org/10.1017/S0954579415000255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

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