Autism and Phthalate Metabolite Glucuronidation / T. Peter STEIN in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685 Titre : Autism and Phthalate Metabolite Glucuronidation Type de document : Texte imprimé et/ou numérique Auteurs : T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur Article en page(s) : p.2677-2685 Langues : Anglais (eng) Mots-clés : Diethylhexyl phthalate  Phthalates  Autism  Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Autism and Phthalate Metabolite Glucuronidation [Texte imprimé et/ou numérique] / T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur . - p.2677-2685. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685 Mots-clés : Diethylhexyl phthalate  Phthalates  Autism  Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Bisphenol A Exposure in Children With Autism Spectrum Disorders / T. Peter STEIN in Autism Research, 8-3 (June 2015)  

Public ISBD [article]  inAutism Research > 8-3 (June 2015) . - p.272-283 Titre : Bisphenol A Exposure in Children With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Lining GUO, Auteur ; Xue MING, Auteur Article en page(s) : p.272-283 Langues : Anglais (eng) Mots-clés : bisphenol A (BPA)  autism spectrum disorders  glucuronidation  phthalates  plasticizers Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is believed to involve genetic and environmental components. This study focused on the plasticizer, Bisphenol-A (BPA). The major pathway for BPA metabolism and excretion is via glucuronidation. To determine whether there was a relationship between BPA exposure and ASD, urine specimens were collected from 46 children with ASD and 52 controls. Free and total BPA concentrations were determined by mass spectrometry. The fraction glucuronidated was calculated from the difference. A metabolomics study was done to investigate metabolite distribution in the urine. (i) Most of the BPA excreted in the urine was as the glucuronide; (ii) about 20% of the ASD children had BPA levels beyond the 90th percentile (>50 ng/mL) of the frequency distribution for the total sample of 98 children; (iii) Mann–Whitney U tests and multiple regression analyses found significant differences (P?|0.30| between metabolite concentrations and total BPA was ?3 times greater with the ASD group than the controls (P??|0.30| for % bound BPA was ?15 times higher with ASD (P? En ligne : http://dx.doi.org/10.1002/aur.1444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Bisphenol A Exposure in Children With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Lining GUO, Auteur ; Xue MING, Auteur . - p.272-283. Langues : Anglais (eng) in Autism Research > 8-3 (June 2015) . - p.272-283 Mots-clés : bisphenol A (BPA)  autism spectrum disorders  glucuronidation  phthalates  plasticizers Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is believed to involve genetic and environmental components. This study focused on the plasticizer, Bisphenol-A (BPA). The major pathway for BPA metabolism and excretion is via glucuronidation. To determine whether there was a relationship between BPA exposure and ASD, urine specimens were collected from 46 children with ASD and 52 controls. Free and total BPA concentrations were determined by mass spectrometry. The fraction glucuronidated was calculated from the difference. A metabolomics study was done to investigate metabolite distribution in the urine. (i) Most of the BPA excreted in the urine was as the glucuronide; (ii) about 20% of the ASD children had BPA levels beyond the 90th percentile (>50 ng/mL) of the frequency distribution for the total sample of 98 children; (iii) Mann–Whitney U tests and multiple regression analyses found significant differences (P?|0.30| between metabolite concentrations and total BPA was ?3 times greater with the ASD group than the controls (P??|0.30| for % bound BPA was ?15 times higher with ASD (P? En ligne : http://dx.doi.org/10.1002/aur.1444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Environmental Toxicants and Autism Spectrum Disorders / Xue MING in Autism - Open Access, 2-2 (July 2012)  

Public ISBD [article]  inAutism - Open Access > 2-2 (July 2012) . - 2 p. Titre : Environmental Toxicants and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Xue MING, Auteur Année de publication : 2012 Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Environmental Toxicants and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Xue MING, Auteur . - 2012 . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 2-2 (July 2012) . - 2 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders / Victor KANG in Autism Research, 7-4 (August 2014)  

Public ISBD [article]  inAutism Research > 7-4 (August 2014) . - p.501-506 Titre : Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur Année de publication : 2014 Article en page(s) : p.501-506 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  gastrointestinal disorders  comorbid disorders  endoscopy  colonoscopy  inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur . - 2014 . - p.501-506. Langues : Anglais (eng) in Autism Research > 7-4 (August 2014) . - p.501-506 Mots-clés : autism spectrum disorders  gastrointestinal disorders  comorbid disorders  endoscopy  colonoscopy  inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

The Utility of MRI in Children with Autism Spectrum Disorder / Xue MING in Autism - Open Access, 6-1 ([01/01/2016])  

Public ISBD [article]  inAutism - Open Access > 6-1 [01/01/2016] . - 4 p. Titre : The Utility of MRI in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xue MING, Auteur ; Mary O’CONNOR, Auteur ; Savitra BANDARI, Auteur ; Wenzhuan HE, Auteur ; Gretchen BREWER, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Magnetic resonance imaging  Autism spectrum disorders  Parenchymal brain abnormalities  Epilepsy  Neuroimaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of brain based disorders associated with co-occurring medical conditions, such as epilepsy. With highly specialized imaging technology revealing functional and structural abnormalities in the brains of patients with ASD, the role of routine structural conventional Magnetic Resonance Imaging (MRI) is controversial and may not be a useful tool for the purpose of diagnosis and treatment. This study evaluated the utility of conventional routine MRI in ASD with and without co-occurring epilepsy. We reviewed the records of children with ASD ages 8-17 years and performed statistical analysis comparing MRI brain abnormalities and epilepsy. Seventy-seven of 253 subjects underwent brain imaging, 55 had MRI results available and, of these, 8had brain parenchymal abnormalities. These abnormalities included two subjects with Chiari I malformation, one each with hamartoma, enlarged vascular space, venous angioma, and three with abnormal white matter signals. Brain MRI parenchymal abnormalities were not associated with the presence of epilepsy in children with ASD. In our cohort, conventional routine MRI was not useful as a tool that could lead to immediate diagnosis or treatment. The benefit and risks of conventional brain MRI for children with ASD should be carefully weighed. If an imaging study is highly suggested, some of the clinically available advanced imaging technologies should be considered in place of conventional MRI. En ligne : https://dx.doi.org/10.4172/2165-7890.1000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] The Utility of MRI in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Xue MING, Auteur ; Mary O’CONNOR, Auteur ; Savitra BANDARI, Auteur ; Wenzhuan HE, Auteur ; Gretchen BREWER, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 6-1 [01/01/2016] . - 4 p. Mots-clés : Magnetic resonance imaging  Autism spectrum disorders  Parenchymal brain abnormalities  Epilepsy  Neuroimaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of brain based disorders associated with co-occurring medical conditions, such as epilepsy. With highly specialized imaging technology revealing functional and structural abnormalities in the brains of patients with ASD, the role of routine structural conventional Magnetic Resonance Imaging (MRI) is controversial and may not be a useful tool for the purpose of diagnosis and treatment. This study evaluated the utility of conventional routine MRI in ASD with and without co-occurring epilepsy. We reviewed the records of children with ASD ages 8-17 years and performed statistical analysis comparing MRI brain abnormalities and epilepsy. Seventy-seven of 253 subjects underwent brain imaging, 55 had MRI results available and, of these, 8had brain parenchymal abnormalities. These abnormalities included two subjects with Chiari I malformation, one each with hamartoma, enlarged vascular space, venous angioma, and three with abnormal white matter signals. Brain MRI parenchymal abnormalities were not associated with the presence of epilepsy in children with ASD. In our cohort, conventional routine MRI was not useful as a tool that could lead to immediate diagnosis or treatment. The benefit and risks of conventional brain MRI for children with ASD should be carefully weighed. If an imaging study is highly suggested, some of the clinically available advanced imaging technologies should be considered in place of conventional MRI. En ligne : https://dx.doi.org/10.4172/2165-7890.1000164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

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