Autism and Phthalate Metabolite Glucuronidation / T. Peter STEIN in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685 Titre : Autism and Phthalate Metabolite Glucuronidation Type de document : texte imprimé Auteurs : T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur Article en page(s) : p.2677-2685 Langues : Anglais (eng) Mots-clés : Diethylhexyl phthalate  Phthalates  Autism  Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] Autism and Phthalate Metabolite Glucuronidation [texte imprimé] / T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur . - p.2677-2685. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685 Mots-clés : Diethylhexyl phthalate  Phthalates  Autism  Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

Bisphenol A Exposure in Children With Autism Spectrum Disorders / T. Peter STEIN in Autism Research, 8-3 (June 2015)  

Public ISBD [article]  inAutism Research > 8-3 (June 2015) . - p.272-283 Titre : Bisphenol A Exposure in Children With Autism Spectrum Disorders Type de document : texte imprimé Auteurs : T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Lining GUO, Auteur ; Xue MING, Auteur Article en page(s) : p.272-283 Langues : Anglais (eng) Mots-clés : bisphenol A (BPA)  autism spectrum disorders  glucuronidation  phthalates  plasticizers Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is believed to involve genetic and environmental components. This study focused on the plasticizer, Bisphenol-A (BPA). The major pathway for BPA metabolism and excretion is via glucuronidation. To determine whether there was a relationship between BPA exposure and ASD, urine specimens were collected from 46 children with ASD and 52 controls. Free and total BPA concentrations were determined by mass spectrometry. The fraction glucuronidated was calculated from the difference. A metabolomics study was done to investigate metabolite distribution in the urine. (i) Most of the BPA excreted in the urine was as the glucuronide; (ii) about 20% of the ASD children had BPA levels beyond the 90th percentile (>50 ng/mL) of the frequency distribution for the total sample of 98 children; (iii) Mann–Whitney U tests and multiple regression analyses found significant differences (P < 0.05) between the groups in total and % bound BPA; and (iv) the metabolomics analyses showed the number of absolute partial correlations >|0.30| between metabolite concentrations and total BPA was ∼3 times greater with the ASD group than the controls (P < 0.001), and the number of absolute partial correlations > |0.30| for % bound BPA was ∼15 times higher with ASD (P < 0.001). The results suggest there is an association between BPA and ASD. En ligne : http://dx.doi.org/10.1002/aur.1444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Bisphenol A Exposure in Children With Autism Spectrum Disorders [texte imprimé] / T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Lining GUO, Auteur ; Xue MING, Auteur . - p.272-283. Langues : Anglais (eng) in Autism Research > 8-3 (June 2015) . - p.272-283 Mots-clés : bisphenol A (BPA)  autism spectrum disorders  glucuronidation  phthalates  plasticizers Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is believed to involve genetic and environmental components. This study focused on the plasticizer, Bisphenol-A (BPA). The major pathway for BPA metabolism and excretion is via glucuronidation. To determine whether there was a relationship between BPA exposure and ASD, urine specimens were collected from 46 children with ASD and 52 controls. Free and total BPA concentrations were determined by mass spectrometry. The fraction glucuronidated was calculated from the difference. A metabolomics study was done to investigate metabolite distribution in the urine. (i) Most of the BPA excreted in the urine was as the glucuronide; (ii) about 20% of the ASD children had BPA levels beyond the 90th percentile (>50 ng/mL) of the frequency distribution for the total sample of 98 children; (iii) Mann–Whitney U tests and multiple regression analyses found significant differences (P < 0.05) between the groups in total and % bound BPA; and (iv) the metabolomics analyses showed the number of absolute partial correlations >|0.30| between metabolite concentrations and total BPA was ∼3 times greater with the ASD group than the controls (P < 0.001), and the number of absolute partial correlations > |0.30| for % bound BPA was ∼15 times higher with ASD (P < 0.001). The results suggest there is an association between BPA and ASD. En ligne : http://dx.doi.org/10.1002/aur.1444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Environmental Toxicants and Autism Spectrum Disorders / Xue MING in Autism - Open Access, 2-2 (July 2012)  

Public ISBD [article]  inAutism - Open Access > 2-2 (July 2012) . - 2 p. Titre : Environmental Toxicants and Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Xue MING, Auteur Année de publication : 2012 Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Environmental Toxicants and Autism Spectrum Disorders [texte imprimé] / Xue MING, Auteur . - 2012 . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 2-2 (July 2012) . - 2 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.4172/2165-7890.1000e108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders / Victor KANG in Autism Research, 7-4 (August 2014)  

Public ISBD [article]  inAutism Research > 7-4 (August 2014) . - p.501-506 Titre : Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur Année de publication : 2014 Article en page(s) : p.501-506 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  gastrointestinal disorders  comorbid disorders  endoscopy  colonoscopy  inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders [texte imprimé] / Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur . - 2014 . - p.501-506. Langues : Anglais (eng) in Autism Research > 7-4 (August 2014) . - p.501-506 Mots-clés : autism spectrum disorders  gastrointestinal disorders  comorbid disorders  endoscopy  colonoscopy  inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder / Venkatraman THULASI in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.524-530 Titre : Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder Type de document : texte imprimé Auteurs : Venkatraman THULASI, Auteur ; Robert A. STEER, Auteur ; Iona M. MONTEIRO, Auteur ; Xue MING, Auteur Article en page(s) : p.524-530 Langues : Anglais (eng) Mots-clés : Gastrointestinal Severity Scale  autism spectrum disorders  constipation  diarrhea  gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder [texte imprimé] / Venkatraman THULASI, Auteur ; Robert A. STEER, Auteur ; Iona M. MONTEIRO, Auteur ; Xue MING, Auteur . - p.524-530. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.524-530 Mots-clés : Gastrointestinal Severity Scale  autism spectrum disorders  constipation  diarrhea  gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

The Utility of MRI in Children with Autism Spectrum Disorder / Xue MING in Autism - Open Access, 6-1 ([01/01/2016])  

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