Brief Report: Effects of Solution-Focused Brief Therapy Group-Work on Promoting Post-traumatic Growth of Mothers Who Have a Child with ASD / Wei ZHANG in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2052-2056 Titre : Brief Report: Effects of Solution-Focused Brief Therapy Group-Work on Promoting Post-traumatic Growth of Mothers Who Have a Child with ASD Type de document : texte imprimé Auteurs : Wei ZHANG, Auteur ; Ting-ting YAN, Auteur ; Ya-song DU, Auteur ; Xiao-Hong LIU, Auteur Article en page(s) : p.2052-2056 Langues : Anglais (eng) Mots-clés : Mothers  Post-traumatic growth  Solution-focused brief therapy  Group counseling Index. décimale : PER Périodiques Résumé : The study evaluated the impact of solution-focused brief therapy (SFBT) group-work on the post-traumatic growth (PTG) of mothers who have a child with ASD. A quasi-experimental design was used in which 43 mothers participated. 18 mothers in 2 SFBT groups (n = 9 in each group) received a 6-session SFBT group therapy while 25 mothers in a control group received no treatment. The Post-traumatic Growth Inventory was used to measure the PTG levels of the participants at baseline, post-treatment and 6-month follow-up assessments. Mothers who attended SFBT group-work reported higher PTG scores both at post-treatment (t = 4.065, p = .001) and 6-month follow-up (t = 2.980, p = .006) assessments. Further investigations to prove whether SFBT in groups can increase the positivity of clients would promote the use of SFBT. En ligne : http://dx.doi.org/10.1007/s10803-014-2051-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Brief Report: Effects of Solution-Focused Brief Therapy Group-Work on Promoting Post-traumatic Growth of Mothers Who Have a Child with ASD [texte imprimé] / Wei ZHANG, Auteur ; Ting-ting YAN, Auteur ; Ya-song DU, Auteur ; Xiao-Hong LIU, Auteur . - p.2052-2056. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2052-2056 Mots-clés : Mothers  Post-traumatic growth  Solution-focused brief therapy  Group counseling Index. décimale : PER Périodiques Résumé : The study evaluated the impact of solution-focused brief therapy (SFBT) group-work on the post-traumatic growth (PTG) of mothers who have a child with ASD. A quasi-experimental design was used in which 43 mothers participated. 18 mothers in 2 SFBT groups (n = 9 in each group) received a 6-session SFBT group therapy while 25 mothers in a control group received no treatment. The Post-traumatic Growth Inventory was used to measure the PTG levels of the participants at baseline, post-treatment and 6-month follow-up assessments. Mothers who attended SFBT group-work reported higher PTG scores both at post-treatment (t = 4.065, p = .001) and 6-month follow-up (t = 2.980, p = .006) assessments. Further investigations to prove whether SFBT in groups can increase the positivity of clients would promote the use of SFBT. En ligne : http://dx.doi.org/10.1007/s10803-014-2051-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation / Zhu WEN in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 43p. Titre : Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation Type de document : texte imprimé Auteurs : Zhu WEN, Auteur ; Tian-Lin CHENG, Auteur ; Gai-Zhi LI, Auteur ; Shi-Bang SUN, Auteur ; Shun-Ying YU, Auteur ; Yi ZHANG, Auteur ; Ya-song DU, Auteur ; Zilong QIU, Auteur Article en page(s) : 43p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Methyl-CpG-binding protein-2 (MeCP2)  Neural development  Whole-exome sequencing Index. décimale : PER Périodiques Résumé : BACKGROUND: Methyl-CpG-binding protein-2 (MeCP2) is a critical regulator for neural development. Either loss- or gain-of-function leads to severe neurodevelopmental disorders, such as Rett syndrome (RTT) and autism spectrum disorder (ASD). We set out to screen for MECP2 mutations in patients of ASD and determine whether these autism-related mutations may compromise the proper function of MeCP2. METHODS: Whole-exome sequencing was performed to screen MECP2 and other ASD candidate genes for 120 patients diagnosed with ASD. The parents of patients who were identified with MECP2 mutation were selected for further Sanger sequencing. Each patient accomplished the case report form including general information and clinical scales applied to assess their clinical features. Mouse cortical neurons and HEK-293 cells were cultured and transfected with MeCP2 wild-type (WT) or mutant to examine the function of autism-associated MeCP2 mutants. HEK-293 cells were used to examine the expression of MeCP2 mutant constructs with Western blot. Mouse cortical neurons were used to analyze neurites and axon outgrowth by immunofluorescence experiments. RESULTS: We identified three missense mutations of MECP2 from three autism patients by whole-exome sequencing: p.P152L (c.455C>T), p.P376S (c.1162C>T), and p.R294X (c.880C>T). Among these mutations, p.P152L and p.R294X were de novo mutations, whereas p.P376S was inherited maternally. The diagnosis of RTT was excluded in all three autism patients. Abnormalities of dendritic and axonal growth were found after autism-related MeCP2 mutants were expressed in mouse cortical neurons; suggesting that autism-related MECP2 mutations impair the proper development of neurons. CONCLUSIONS: Our study identified genetic mutations of the MECP2 gene in autism patients, which were previously considered to be associated primarily with RTT. This finding suggests that loss-of-function mutations of MECP2 may also lead to autism spectrum disorders. En ligne : http://dx.doi.org/10.1186/s13229-017-0157-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation [texte imprimé] / Zhu WEN, Auteur ; Tian-Lin CHENG, Auteur ; Gai-Zhi LI, Auteur ; Shi-Bang SUN, Auteur ; Shun-Ying YU, Auteur ; Yi ZHANG, Auteur ; Ya-song DU, Auteur ; Zilong QIU, Auteur . - 43p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 43p. Mots-clés : Autism spectrum disorder  Methyl-CpG-binding protein-2 (MeCP2)  Neural development  Whole-exome sequencing Index. décimale : PER Périodiques Résumé : BACKGROUND: Methyl-CpG-binding protein-2 (MeCP2) is a critical regulator for neural development. Either loss- or gain-of-function leads to severe neurodevelopmental disorders, such as Rett syndrome (RTT) and autism spectrum disorder (ASD). We set out to screen for MECP2 mutations in patients of ASD and determine whether these autism-related mutations may compromise the proper function of MeCP2. METHODS: Whole-exome sequencing was performed to screen MECP2 and other ASD candidate genes for 120 patients diagnosed with ASD. The parents of patients who were identified with MECP2 mutation were selected for further Sanger sequencing. Each patient accomplished the case report form including general information and clinical scales applied to assess their clinical features. Mouse cortical neurons and HEK-293 cells were cultured and transfected with MeCP2 wild-type (WT) or mutant to examine the function of autism-associated MeCP2 mutants. HEK-293 cells were used to examine the expression of MeCP2 mutant constructs with Western blot. Mouse cortical neurons were used to analyze neurites and axon outgrowth by immunofluorescence experiments. RESULTS: We identified three missense mutations of MECP2 from three autism patients by whole-exome sequencing: p.P152L (c.455C>T), p.P376S (c.1162C>T), and p.R294X (c.880C>T). Among these mutations, p.P152L and p.R294X were de novo mutations, whereas p.P376S was inherited maternally. The diagnosis of RTT was excluded in all three autism patients. Abnormalities of dendritic and axonal growth were found after autism-related MeCP2 mutants were expressed in mouse cortical neurons; suggesting that autism-related MECP2 mutations impair the proper development of neurons. CONCLUSIONS: Our study identified genetic mutations of the MECP2 gene in autism patients, which were previously considered to be associated primarily with RTT. This finding suggests that loss-of-function mutations of MECP2 may also lead to autism spectrum disorders. En ligne : http://dx.doi.org/10.1186/s13229-017-0157-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders / Wei ZHANG in Research in Autism Spectrum Disorders, 7-10 (October 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-10 (October 2013) . - p.1204-1210 Titre : Relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders Type de document : texte imprimé Auteurs : Wei ZHANG, Auteur ; Ting-ting YAN, Auteur ; Ya-song DU, Auteur ; Xiao-Hong LIU, Auteur Article en page(s) : p.1204-1210 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Caregiver  Mothers  Rumination  Coping  Posttraumatic growth Index. décimale : PER Périodiques Résumé : This study examined the relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders (ASD). One hundred and two mothers of autistic children in China were surveyed using Post-traumatic Growth Inventory, Trait Coping Style Questionnaire, and Event Related Rumination Inventory. Mothers reported mediate level of PTG, mostly on the growth of personal strength. Hierarchal regression analysis indicated that positive coping positively predicted PTG and growth on “relating to others”; deliberate rumination was positively correlated with growth on “appreciation of life”; and intrusive rumination negatively predicted growth on “personal strength”, “new possibilities” and “spiritual change”. No statistically significant relationship between negative coping and PTG was found. The results may be used to provide mothers with a better understanding of the underlying growth process and assist service providers in facilitating this progress. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.07.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders [texte imprimé] / Wei ZHANG, Auteur ; Ting-ting YAN, Auteur ; Ya-song DU, Auteur ; Xiao-Hong LIU, Auteur . - p.1204-1210. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-10 (October 2013) . - p.1204-1210 Mots-clés : Autism spectrum disorder  Caregiver  Mothers  Rumination  Coping  Posttraumatic growth Index. décimale : PER Périodiques Résumé : This study examined the relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders (ASD). One hundred and two mothers of autistic children in China were surveyed using Post-traumatic Growth Inventory, Trait Coping Style Questionnaire, and Event Related Rumination Inventory. Mothers reported mediate level of PTG, mostly on the growth of personal strength. Hierarchal regression analysis indicated that positive coping positively predicted PTG and growth on “relating to others”; deliberate rumination was positively correlated with growth on “appreciation of life”; and intrusive rumination negatively predicted growth on “personal strength”, “new possibilities” and “spiritual change”. No statistically significant relationship between negative coping and PTG was found. The results may be used to provide mothers with a better understanding of the underlying growth process and assist service providers in facilitating this progress. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.07.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

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