Anxiety symptom trajectories from treatment to 5- to 12-year follow-up across childhood and adolescence / Sunhye BAI in Journal of Child Psychology and Psychiatry, 64-9 (September 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1336-1345 Titre : Anxiety symptom trajectories from treatment to 5- to 12-year follow-up across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Sunhye BAI, Auteur ; Benjamin ROLON-ARROYO, Auteur ; John T. WALKUP, Auteur ; Philip C. KENDALL, Auteur ; Golda S. GINSBURG, Auteur ; Courtney P. KEETON, Auteur ; Anne Marie ALBANO, Auteur ; Scott N. COMPTON, Auteur ; Dara SAKOLSKY, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur Article en page(s) : p.1336-1345 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Objective The current study examined trajectories of anxiety during (a) acute treatment and (b) extended follow-up to better characterize the long-term symptom trajectories of youth who received evidence-based intervention for anxiety disorders using a person-centered approach. Method Participants were 319 youth (age 7-17?years at enrollment), who participated in a multicenter randomized controlled trial for the treatment of pediatric anxiety disorders, Child/Adolescent Anxiety Multimodal Study, and a 4-year naturalistic follow-up, Child/Adolescent Anxiety Multimodal Extended Long-term Study, an average of 6.5?years later. Using growth mixture modeling, the study identified distinct trajectories of anxiety across acute treatment (Weeks 0-12), posttreatment (Weeks 12-36), and the 4-year-long follow-up, and identified baseline predictors of these trajectories. Results Three nonlinear anxiety trajectories emerged: "short-term responders" who showed rapid treatment response but had higher levels of anxiety during the extended follow-up; "durable responders" who sustained treatment gains; and "delayed remitters" who did not show an initial response to treatment, but showed low levels of anxiety during the maintenance and extended follow-up periods. Worse anxiety severity and better family functioning at baseline predicted membership in the delayed remitters group. Caregiver strain differentiated short-term responders from durable responders. Conclusions Findings suggest that initial response to treatment does not guarantee sustained treatment gains over time for some youth. Future follow-up studies that track treated youth across key developmental transitions and in the context of changing social environments are needed to inform best practices for the long-term management of anxiety. En ligne : https://doi.org/10.1111/jcpp.13796 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Anxiety symptom trajectories from treatment to 5- to 12-year follow-up across childhood and adolescence [Texte imprimé et/ou numérique] / Sunhye BAI, Auteur ; Benjamin ROLON-ARROYO, Auteur ; John T. WALKUP, Auteur ; Philip C. KENDALL, Auteur ; Golda S. GINSBURG, Auteur ; Courtney P. KEETON, Auteur ; Anne Marie ALBANO, Auteur ; Scott N. COMPTON, Auteur ; Dara SAKOLSKY, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur . - p.1336-1345. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1336-1345 Index. décimale : PER Périodiques Résumé : Objective The current study examined trajectories of anxiety during (a) acute treatment and (b) extended follow-up to better characterize the long-term symptom trajectories of youth who received evidence-based intervention for anxiety disorders using a person-centered approach. Method Participants were 319 youth (age 7-17?years at enrollment), who participated in a multicenter randomized controlled trial for the treatment of pediatric anxiety disorders, Child/Adolescent Anxiety Multimodal Study, and a 4-year naturalistic follow-up, Child/Adolescent Anxiety Multimodal Extended Long-term Study, an average of 6.5?years later. Using growth mixture modeling, the study identified distinct trajectories of anxiety across acute treatment (Weeks 0-12), posttreatment (Weeks 12-36), and the 4-year-long follow-up, and identified baseline predictors of these trajectories. Results Three nonlinear anxiety trajectories emerged: "short-term responders" who showed rapid treatment response but had higher levels of anxiety during the extended follow-up; "durable responders" who sustained treatment gains; and "delayed remitters" who did not show an initial response to treatment, but showed low levels of anxiety during the maintenance and extended follow-up periods. Worse anxiety severity and better family functioning at baseline predicted membership in the delayed remitters group. Caregiver strain differentiated short-term responders from durable responders. Conclusions Findings suggest that initial response to treatment does not guarantee sustained treatment gains over time for some youth. Future follow-up studies that track treated youth across key developmental transitions and in the context of changing social environments are needed to inform best practices for the long-term management of anxiety. En ligne : https://doi.org/10.1111/jcpp.13796 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Dimensional psychopathology in preschool offspring of parents with bipolar disorder / Hagai MAOZ in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.144-153 Titre : Dimensional psychopathology in preschool offspring of parents with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hagai MAOZ, Auteur ; Tina R. GOLDSTEIN, Auteur ; David A. AXELSON, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jieyu FAN, Auteur ; Mary Beth HICKEY, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Rasim S. DILER, Auteur ; David A. BRENT, Auteur ; Satish IYENGAR, Auteur ; David J. KUPFER, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.144-153 Langues : Anglais (eng) Mots-clés : BP  offspring  dimensional psychopathology Index. décimale : PER Périodiques Résumé : Background The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (BP) and offspring of community control parents. Methods 122 preschool offspring (mean age 3.3 years) of 84 parents with BP, with 102 offspring of 65 control parents (36 healthy, 29 with non-BP psychopathology), were evaluated using the Child Behavior Checklist (CBCL), the CBCL-Dysregulation Profile (CBCL-DP), the Early Childhood Inventory (ECI-4), and the Emotionality Activity Sociability (EAS) survey. Teachers' Report Forms (TRF) were available for 51 preschoolers. Results After adjusting for confounders, offspring of parents with BP showed higher scores in the CBCL total, externalizing, somatic, sleep, aggressive, and CBCL-DP subscales; the ECI-4 sleep problem scale; and the EAS total and emotionality scale. The proportion of offspring with CBCL T-scores ?2 SD above the norm was significantly higher on most CBCL subscales and the CBCL-DP in offspring of parents with BP compared to offspring of controls even after excluding offspring with attention deficit hyperactivity disorder and/or oppositional defiant disorder. Compared to offspring of parents with BP-I, offspring of parents with BP-II showed significantly higher scores in total and most CBCL subscales, the ECI-4 anxiety and sleep scales and the EAS emotionality scale. For both groups of parents, there were significant correlations between CBCL and TRF scores (r = .32–.38, p-values ?.02). Conclusions Independent of categorical axis-I psychopathology and other demographic or clinical factors in both biological parents, preschool offspring of parents with BP have significantly greater aggression, mood dysregulation, sleep disturbances, and somatic complaints compared to offspring of control parents. Interventions to target these symptoms are warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Dimensional psychopathology in preschool offspring of parents with bipolar disorder [Texte imprimé et/ou numérique] / Hagai MAOZ, Auteur ; Tina R. GOLDSTEIN, Auteur ; David A. AXELSON, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jieyu FAN, Auteur ; Mary Beth HICKEY, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Rasim S. DILER, Auteur ; David A. BRENT, Auteur ; Satish IYENGAR, Auteur ; David J. KUPFER, Auteur ; Boris BIRMAHER, Auteur . - p.144-153. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.144-153 Mots-clés : BP  offspring  dimensional psychopathology Index. décimale : PER Périodiques Résumé : Background The purpose of this study is to compare the dimensional psychopathology, as ascertained by parental report, in preschool offspring of parents with bipolar disorder (BP) and offspring of community control parents. Methods 122 preschool offspring (mean age 3.3 years) of 84 parents with BP, with 102 offspring of 65 control parents (36 healthy, 29 with non-BP psychopathology), were evaluated using the Child Behavior Checklist (CBCL), the CBCL-Dysregulation Profile (CBCL-DP), the Early Childhood Inventory (ECI-4), and the Emotionality Activity Sociability (EAS) survey. Teachers' Report Forms (TRF) were available for 51 preschoolers. Results After adjusting for confounders, offspring of parents with BP showed higher scores in the CBCL total, externalizing, somatic, sleep, aggressive, and CBCL-DP subscales; the ECI-4 sleep problem scale; and the EAS total and emotionality scale. The proportion of offspring with CBCL T-scores ?2 SD above the norm was significantly higher on most CBCL subscales and the CBCL-DP in offspring of parents with BP compared to offspring of controls even after excluding offspring with attention deficit hyperactivity disorder and/or oppositional defiant disorder. Compared to offspring of parents with BP-I, offspring of parents with BP-II showed significantly higher scores in total and most CBCL subscales, the ECI-4 anxiety and sleep scales and the EAS emotionality scale. For both groups of parents, there were significant correlations between CBCL and TRF scores (r = .32–.38, p-values ?.02). Conclusions Independent of categorical axis-I psychopathology and other demographic or clinical factors in both biological parents, preschool offspring of parents with BP have significantly greater aggression, mood dysregulation, sleep disturbances, and somatic complaints compared to offspring of control parents. Interventions to target these symptoms are warranted. En ligne : http://dx.doi.org/10.1111/jcpp.12137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder / Danella M. HAFEMAN in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Titre : Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.1492-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder [Texte imprimé et/ou numérique] / Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur . - p.1492-1500. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5?years old) and then approximately every 2?years for a mean of 10.6?years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Substance use outcomes from the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS) / Thomas M. OLINO ; Anne Marie ALBANO ; Courtney P. KEETON ; Dara SAKOLSKY ; Boris BIRMAHER ; John PIACENTINI ; Tara S. PERIS ; Scott N. COMPTON ; Elizabeth GOSCH ; Golda S. GINSBURG ; Elizabeth L. PINNEY ; Philip C. KENDALL in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.910-920 Titre : Substance use outcomes from the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS) Type de document : Texte imprimé et/ou numérique Auteurs : Thomas M. OLINO, Auteur ; Anne Marie ALBANO, Auteur ; Courtney P. KEETON, Auteur ; Dara SAKOLSKY, Auteur ; Boris BIRMAHER, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur ; Scott N. COMPTON, Auteur ; Elizabeth GOSCH, Auteur ; Golda S. GINSBURG, Auteur ; Elizabeth L. PINNEY, Auteur ; Philip C. KENDALL, Auteur Article en page(s) : p.910-920 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Substance use problems and anxiety disorders are both highly prevalent and frequently cooccur in youth. The present study examined the benefits of successful anxiety treatment at 3-12?years after treatment completion on substance use outcomes (i.e. diagnoses and lifetime expected use). Methods The sample was from the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), a naturalistic follow-up study to the Child/Adolescent Anxiety Multimodal Study (CAMS) which randomized youth to cognitive behavioral therapy (CBT; Coping cat), medication (sertraline), their combination, or pill placebo. The first CAMELS visit occurred an average of 6.5?years following CAMS randomization. Participants were 319 youth (65.4% of the CAMS sample), aged 7-17?years at CAMS baseline assessment with a mean age of 17.6?years (range: 11-26?years) at the time of the first CAMELS follow-up. Substance use outcomes included diagnoses as well as lifetime substance use (i.e. alcohol and tobacco use). Results Eleven of 319 (3.4%) CAMELS participants were diagnosed with a substance use disorder at the initial follow-up visit. When compared to the population lifetime rate of 11.4%, the rate of diagnoses in the posttreated sample was significantly lower. Additionally, rates of lifetime alcohol use were lower than population rates at the initial and final follow-up visits. Rates of lifetime tobacco use were similarly lower than lifetime population rates at the initial visit (driven by significantly lower rates in the CBT treatment condition), but higher by the final visit. Furthermore, treatment remission (but not treatment response) was associated with a lower rate of substance use diagnoses at the initial follow-up visit, although rates of lifetime alcohol and tobacco use did not differ by treatment outcome. Conclusions Anxiety treatments confer a beneficial impact on problematic substance use (i.e. diagnoses) as well as on expected substance use (i.e. alcohol and tobacco use) for on average, a period of 6.5?years. En ligne : https://doi.org/10.1111/jcpp.13926 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Substance use outcomes from the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS) [Texte imprimé et/ou numérique] / Thomas M. OLINO, Auteur ; Anne Marie ALBANO, Auteur ; Courtney P. KEETON, Auteur ; Dara SAKOLSKY, Auteur ; Boris BIRMAHER, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur ; Scott N. COMPTON, Auteur ; Elizabeth GOSCH, Auteur ; Golda S. GINSBURG, Auteur ; Elizabeth L. PINNEY, Auteur ; Philip C. KENDALL, Auteur . - p.910-920. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-7 (July 2024) . - p.910-920 Index. décimale : PER Périodiques Résumé : Background Substance use problems and anxiety disorders are both highly prevalent and frequently cooccur in youth. The present study examined the benefits of successful anxiety treatment at 3-12?years after treatment completion on substance use outcomes (i.e. diagnoses and lifetime expected use). Methods The sample was from the Child/Adolescent Anxiety Multimodal Extended Long-term Study (CAMELS), a naturalistic follow-up study to the Child/Adolescent Anxiety Multimodal Study (CAMS) which randomized youth to cognitive behavioral therapy (CBT; Coping cat), medication (sertraline), their combination, or pill placebo. The first CAMELS visit occurred an average of 6.5?years following CAMS randomization. Participants were 319 youth (65.4% of the CAMS sample), aged 7-17?years at CAMS baseline assessment with a mean age of 17.6?years (range: 11-26?years) at the time of the first CAMELS follow-up. Substance use outcomes included diagnoses as well as lifetime substance use (i.e. alcohol and tobacco use). Results Eleven of 319 (3.4%) CAMELS participants were diagnosed with a substance use disorder at the initial follow-up visit. When compared to the population lifetime rate of 11.4%, the rate of diagnoses in the posttreated sample was significantly lower. Additionally, rates of lifetime alcohol use were lower than population rates at the initial and final follow-up visits. Rates of lifetime tobacco use were similarly lower than lifetime population rates at the initial visit (driven by significantly lower rates in the CBT treatment condition), but higher by the final visit. Furthermore, treatment remission (but not treatment response) was associated with a lower rate of substance use diagnoses at the initial follow-up visit, although rates of lifetime alcohol and tobacco use did not differ by treatment outcome. Conclusions Anxiety treatments confer a beneficial impact on problematic substance use (i.e. diagnoses) as well as on expected substance use (i.e. alcohol and tobacco use) for on average, a period of 6.5?years. En ligne : https://doi.org/10.1111/jcpp.13926 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

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