[article] 
inDevelopment and Psychopathology > 28-1 (February 2016) . - p.199-212

Titre :	Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes
Type de document :	texte imprimé
Auteurs :	Yi LI, Auteur ; Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur
Article en page(s) :	p.199-212
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Children's observed effortful control (EC) at 30, 42, and 54 months (n = 145) was predicted from the interaction between mothers' observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3′-untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3′-UTR VNTR-10, or intron13-G/3′-UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis–stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children's sensitivity/responsivity to early parenting.
En ligne :	http://dx.doi.org/10.1017/S0954579415000383
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

[article] Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes [texte imprimé] / Yi LI, Auteur ; Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur . - p.199-212.
Langues : Anglais (eng)
in Development and Psychopathology > 28-1 (February 2016) . - p.199-212

Index. décimale :	PER Périodiques
Résumé :	Children's observed effortful control (EC) at 30, 42, and 54 months (n = 145) was predicted from the interaction between mothers' observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3′-untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3′-UTR VNTR-10, or intron13-G/3′-UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis–stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children's sensitivity/responsivity to early parenting.
En ligne :	http://dx.doi.org/10.1017/S0954579415000383
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278