[article]
| Titre : |
Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p.478-488 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Steroid hormones Estrogen Alpha-fetoprotein hCG Prenatal screening Estriol |
| Index. décimale : |
PER Périodiques |
| Résumé : |
We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-015-2587-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 |
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488
[article] Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California [Texte imprimé et/ou numérique] / Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Meredith C. ANDERSON, Auteur ; Martin KHARRAZI, Auteur . - 2016 . - p.478-488. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.478-488
| Mots-clés : |
Autism spectrum disorder Steroid hormones Estrogen Alpha-fetoprotein hCG Prenatal screening Estriol |
| Index. décimale : |
PER Périodiques |
| Résumé : |
We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th–74th percentiles = 1.21, 95 % CI 1.06–1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07–1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02–1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05–1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-015-2587-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 |
|
Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California in Journal of Autism and Developmental Disorders, 46-2 (February 2016)
