Annual Research Review: The neurobehavioral development of multiple memory systems – implications for childhood and adolescent psychiatric disorders / Jarid GOODMAN in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.582-610 Titre : Annual Research Review: The neurobehavioral development of multiple memory systems – implications for childhood and adolescent psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jarid GOODMAN, Auteur ; Rachel MARSH, Auteur ; Bradley S. PETERSON, Auteur ; Mark G. PACKARD, Auteur Année de publication : 2014 Article en page(s) : p.582-610 Langues : Anglais (eng) Mots-clés : Learning  memory  neuropsychiatry  psychopathologies  hippocampus  striatum  basal ganglia  anxiety  stress Index. décimale : PER Périodiques Résumé : Extensive evidence indicates that mammalian memory is organized into multiple brains systems, including a ‘cognitive’ memory system that depends on the hippocampus and a stimulus-response ‘habit’ memory system that depends on the dorsolateral striatum. Dorsal striatal-dependent habit memory may in part influence the development and expression of some human psychopathologies, particularly those characterized by strong habit-like behavioral features. The present review considers this hypothesis as it pertains to psychopathologies that typically emerge during childhood and adolescence. These disorders include Tourette syndrome, attention-deficit/hyperactivity disorder, obsessive–compulsive disorder, eating disorders, and autism spectrum disorders. Human and nonhuman animal research shows that the typical development of memory systems comprises the early maturation of striatal-dependent habit memory and the relatively late maturation of hippocampal-dependent cognitive memory. We speculate that the differing rates of development of these memory systems may in part contribute to the early emergence of habit-like symptoms in childhood and adolescence. In addition, abnormalities in hippocampal and striatal brain regions have been observed consistently in youth with these disorders, suggesting that the aberrant development of memory systems may also contribute to the emergence of habit-like symptoms as core pathological features of these illnesses. Considering these disorders within the context of multiple memory systems may help elucidate the pathogenesis of habit-like symptoms in childhood and adolescence, and lead to novel treatments that lessen the habit-like behavioral features of these disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 [article] Annual Research Review: The neurobehavioral development of multiple memory systems – implications for childhood and adolescent psychiatric disorders [Texte imprimé et/ou numérique] / Jarid GOODMAN, Auteur ; Rachel MARSH, Auteur ; Bradley S. PETERSON, Auteur ; Mark G. PACKARD, Auteur . - 2014 . - p.582-610. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.582-610 Mots-clés : Learning  memory  neuropsychiatry  psychopathologies  hippocampus  striatum  basal ganglia  anxiety  stress Index. décimale : PER Périodiques Résumé : Extensive evidence indicates that mammalian memory is organized into multiple brains systems, including a ‘cognitive’ memory system that depends on the hippocampus and a stimulus-response ‘habit’ memory system that depends on the dorsolateral striatum. Dorsal striatal-dependent habit memory may in part influence the development and expression of some human psychopathologies, particularly those characterized by strong habit-like behavioral features. The present review considers this hypothesis as it pertains to psychopathologies that typically emerge during childhood and adolescence. These disorders include Tourette syndrome, attention-deficit/hyperactivity disorder, obsessive–compulsive disorder, eating disorders, and autism spectrum disorders. Human and nonhuman animal research shows that the typical development of memory systems comprises the early maturation of striatal-dependent habit memory and the relatively late maturation of hippocampal-dependent cognitive memory. We speculate that the differing rates of development of these memory systems may in part contribute to the early emergence of habit-like symptoms in childhood and adolescence. In addition, abnormalities in hippocampal and striatal brain regions have been observed consistently in youth with these disorders, suggesting that the aberrant development of memory systems may also contribute to the emergence of habit-like symptoms as core pathological features of these illnesses. Considering these disorders within the context of multiple memory systems may help elucidate the pathogenesis of habit-like symptoms in childhood and adolescence, and lead to novel treatments that lessen the habit-like behavioral features of these disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1299-1308 Titre : Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder Type de document : Texte imprimé et/ou numérique Auteurs : David PAGLIACCIO, Auteur ; Jiook CHA, Auteur ; Xiaofu HE, Auteur ; Marilyn CYR, Auteur ; Paula YANES-LUKIN, Auteur ; Pablo GOLDBERG, Auteur ; Martine FONTAINE, Auteur ; Moira A. RYNN, Auteur ; Rachel MARSH, Auteur Article en page(s) : p.1299-1308 Langues : Anglais (eng) Mots-clés : Child development  Cognitive therapy  Magnetic resonance imaging  Obsessive-compulsive disorder  Structural MRI (sMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD. METHODS: Twenty-eight children/adolescents with OCD and 27 matched healthy participants (7- to 18-year-olds, M = 11.71 years, SD = 3.29) completed high-resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12-16 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix. RESULTS: Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores (all ts > 3.4, FDR-corrected ps < .05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex-wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen's d = 1.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo-opercular regions exhibited fewer streamline counts in OCD (all ts > 3.12, Cohen's ds > 0.92) compared with healthy participants. These connections predicted post-treatment CY-BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness. CONCLUSIONS: The current study identified group differences in structural connectivity (reduced among cingulo-opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT. En ligne : http://dx.doi.org/10.1111/jcpp.13191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder [Texte imprimé et/ou numérique] / David PAGLIACCIO, Auteur ; Jiook CHA, Auteur ; Xiaofu HE, Auteur ; Marilyn CYR, Auteur ; Paula YANES-LUKIN, Auteur ; Pablo GOLDBERG, Auteur ; Martine FONTAINE, Auteur ; Moira A. RYNN, Auteur ; Rachel MARSH, Auteur . - p.1299-1308. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1299-1308 Mots-clés : Child development  Cognitive therapy  Magnetic resonance imaging  Obsessive-compulsive disorder  Structural MRI (sMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD. METHODS: Twenty-eight children/adolescents with OCD and 27 matched healthy participants (7- to 18-year-olds, M = 11.71 years, SD = 3.29) completed high-resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12-16 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix. RESULTS: Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores (all ts > 3.4, FDR-corrected ps < .05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex-wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen's d = 1.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo-opercular regions exhibited fewer streamline counts in OCD (all ts > 3.12, Cohen's ds > 0.92) compared with healthy participants. These connections predicted post-treatment CY-BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness. CONCLUSIONS: The current study identified group differences in structural connectivity (reduced among cingulo-opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT. En ligne : http://dx.doi.org/10.1111/jcpp.13191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

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