Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism / S. Hossein FATEMI in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1833-1845 Titre : Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Oyvind G. RUSTAN, Auteur ; Robert J. ROONEY, Auteur ; Paul D. THURAS, Auteur Article en page(s) : p.1833-1845 Langues : Anglais (eng) Mots-clés : Autism  GABA  Brain  GABR?6  Frontal cortex  GABR?2 Index. décimale : PER Périodiques Résumé : We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABR?6), GABAA receptor beta 2 (GABR?2), GABAA receptor delta (GABR?), GABAA receptor epsilon (GABR?), GABAA receptor gamma 2 (GABR?2), GABAA receptor theta (GABR?), and GABAA receptor rho 2 (GABR?2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAAB subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2078-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Downregulation of GABAA Receptor Protein Subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Oyvind G. RUSTAN, Auteur ; Robert J. ROONEY, Auteur ; Paul D. THURAS, Auteur . - p.1833-1845. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1833-1845 Mots-clés : Autism  GABA  Brain  GABR?6  Frontal cortex  GABR?2 Index. décimale : PER Périodiques Résumé : We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABR?6), GABAA receptor beta 2 (GABR?2), GABAA receptor delta (GABR?), GABAA receptor epsilon (GABR?), GABAA receptor gamma 2 (GABR?2), GABAA receptor theta (GABR?), and GABAA receptor rho 2 (GABR?2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAAB subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-014-2078-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

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