A Twin Study of Heritable and Shared Environmental Contributions to Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025 Titre : A Twin Study of Heritable and Shared Environmental Contributions to Autism Type de document : texte imprimé Auteurs : Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul A. LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur Article en page(s) : p.2013-2025 Langues : Anglais (eng) Mots-clés : Autism  Twins  Genetic  Heritability  Environment  Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92−1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] A Twin Study of Heritable and Shared Environmental Contributions to Autism [texte imprimé] / Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul A. LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur . - p.2013-2025. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025 Mots-clés : Autism  Twins  Genetic  Heritability  Environment  Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92−1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

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