[article] 
inJournal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2138-2147

Titre :	Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	V. M. VOGAN, Auteur ; B. R. MORGAN, Auteur ; R. C. LEUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur ; K. DOYLE-THOMAS, Auteur ; M. J. TAYLOR, Auteur
Article en page(s) :	p.2138-2147
Langues :	Anglais (eng)
Mots-clés :	White matter  Diffusion tensor imaging  Autism Development
Index. décimale :	PER Périodiques
Résumé :	Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7–15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres—tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing.
En ligne :	http://dx.doi.org/10.1007/s10803-016-2744-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

[article] Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / V. M. VOGAN, Auteur ; B. R. MORGAN, Auteur ; R. C. LEUNG, Auteur ; Evdokia ANAGNOSTOU, Auteur ; K. DOYLE-THOMAS, Auteur ; M. J. TAYLOR, Auteur . - p.2138-2147.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-6 (June 2016) . - p.2138-2147

Mots-clés :	White matter  Diffusion tensor imaging  Autism Development
Index. décimale :	PER Périodiques
Résumé :	Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7–15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres—tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing.
En ligne :	http://dx.doi.org/10.1007/s10803-016-2744-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288