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Auteur Evdokia ANAGNOSTOU |
Documents disponibles écrits par cet auteur (67)



Abnormal Brain Dynamics Underlie Speech Production in Children with Autism Spectrum Disorder / Elizabeth W. PANG in Autism Research, 9-2 (February 2016)
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Titre : Abnormal Brain Dynamics Underlie Speech Production in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth W. PANG, Auteur ; Tatiana VALICA, Auteur ; Matt J. MACDONALD, Auteur ; Margot J. TAYLOR, Auteur ; Jessica BRIAN, Auteur ; Jason P. LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.249-261 Langues : Anglais (eng) Mots-clés : magnetoencephalography oromotor control phoneme production phonemic sequencing autism spectrum disorder Index. décimale : PER Périodiques Résumé : A large proportion of children with autism spectrum disorder (ASD) have speech and/or language difficulties. While a number of structural and functional neuroimaging methods have been used to explore the brain differences in ASD with regards to speech and language comprehension and production, the neurobiology of basic speech function in ASD has not been examined. Magnetoencephalography (MEG) is a neuroimaging modality with high spatial and temporal resolution that can be applied to the examination of brain dynamics underlying speech as it can capture the fast responses fundamental to this function. We acquired MEG from 21 children with high-functioning autism (mean age: 11.43 years) and 21 age- and sex-matched controls as they performed a simple oromotor task, a phoneme production task and a phonemic sequencing task. Results showed significant differences in activation magnitude and peak latencies in primary motor cortex (Brodmann Area 4), motor planning areas (BA 6), temporal sequencing and sensorimotor integration areas (BA 22/13) and executive control areas (BA 9). Our findings of significant functional brain differences between these two groups on these simple oromotor and phonemic tasks suggest that these deficits may be foundational and could underlie the language deficits seen in ASD. En ligne : http://dx.doi.org/10.1002/aur.1526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282
in Autism Research > 9-2 (February 2016) . - p.249-261[article] Abnormal Brain Dynamics Underlie Speech Production in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Elizabeth W. PANG, Auteur ; Tatiana VALICA, Auteur ; Matt J. MACDONALD, Auteur ; Margot J. TAYLOR, Auteur ; Jessica BRIAN, Auteur ; Jason P. LERCH, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.249-261.
Langues : Anglais (eng)
in Autism Research > 9-2 (February 2016) . - p.249-261
Mots-clés : magnetoencephalography oromotor control phoneme production phonemic sequencing autism spectrum disorder Index. décimale : PER Périodiques Résumé : A large proportion of children with autism spectrum disorder (ASD) have speech and/or language difficulties. While a number of structural and functional neuroimaging methods have been used to explore the brain differences in ASD with regards to speech and language comprehension and production, the neurobiology of basic speech function in ASD has not been examined. Magnetoencephalography (MEG) is a neuroimaging modality with high spatial and temporal resolution that can be applied to the examination of brain dynamics underlying speech as it can capture the fast responses fundamental to this function. We acquired MEG from 21 children with high-functioning autism (mean age: 11.43 years) and 21 age- and sex-matched controls as they performed a simple oromotor task, a phoneme production task and a phonemic sequencing task. Results showed significant differences in activation magnitude and peak latencies in primary motor cortex (Brodmann Area 4), motor planning areas (BA 6), temporal sequencing and sensorimotor integration areas (BA 22/13) and executive control areas (BA 9). Our findings of significant functional brain differences between these two groups on these simple oromotor and phonemic tasks suggest that these deficits may be foundational and could underlie the language deficits seen in ASD. En ligne : http://dx.doi.org/10.1002/aur.1526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 Alpha connectivity and inhibitory control in adults with autism spectrum disorder / Veronica YUK in Molecular Autism, 11 (2020)
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Titre : Alpha connectivity and inhibitory control in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Veronica YUK, Auteur ; Benjamin T. DUNKLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur Langues : Anglais (eng) Mots-clés : Alpha Autism Connectivity Go/No-go Inhibition Meg Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) often report difficulties with inhibition in everyday life. During inhibition tasks, adults with ASD show reduced activation of and connectivity between brain areas implicated in inhibition, suggesting impairments in inhibitory control at the neural level. Our study further investigated these differences by using magnetoencephalography (MEG) to examine the frequency band(s) in which functional connectivity underlying response inhibition occurs, as brain functions are frequency specific, and whether connectivity in certain frequency bands differs between adults with and without ASD. METHODS: We analysed MEG data from 40 adults with ASD (27 males; 26.94?±?6.08 years old) and 39 control adults (27 males; 27.29?±?5.94 years old) who performed a Go/No-go task. The task involved two blocks with different proportions of No-go trials: Inhibition (25% No-go) and Vigilance (75% No-go). We compared whole-brain connectivity in the two groups during correct No-go trials in the Inhibition vs. Vigilance blocks between 0 and 400 ms. RESULTS: Despite comparable performance on the Go/No-go task, adults with ASD showed reduced connectivity compared to controls in the alpha band (8-14 Hz) in a network with a main hub in the right inferior frontal gyrus. Decreased connectivity in this network predicted more self-reported difficulties on a measure of inhibition in everyday life. LIMITATIONS: Measures of everyday inhibitory control were not available for all participants, so this relationship between reduced network connectivity and inhibitory control abilities may not be necessarily representative of all adults with ASD or the larger ASD population. Further research with independent samples of adults with ASD, including those with a wider range of cognitive abilities, would be valuable. CONCLUSIONS: Our findings demonstrate reduced functional brain connectivity during response inhibition in adults with ASD. As alpha-band synchrony has been linked to top-down control mechanisms, we propose that the lack of alpha synchrony observed in our ASD group may reflect difficulties in suppressing task-irrelevant information, interfering with inhibition in real-life situations. En ligne : http://dx.doi.org/10.1186/s13229-020-00400-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Alpha connectivity and inhibitory control in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Veronica YUK, Auteur ; Benjamin T. DUNKLEY, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Margot J. TAYLOR, Auteur.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Alpha Autism Connectivity Go/No-go Inhibition Meg Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) often report difficulties with inhibition in everyday life. During inhibition tasks, adults with ASD show reduced activation of and connectivity between brain areas implicated in inhibition, suggesting impairments in inhibitory control at the neural level. Our study further investigated these differences by using magnetoencephalography (MEG) to examine the frequency band(s) in which functional connectivity underlying response inhibition occurs, as brain functions are frequency specific, and whether connectivity in certain frequency bands differs between adults with and without ASD. METHODS: We analysed MEG data from 40 adults with ASD (27 males; 26.94?±?6.08 years old) and 39 control adults (27 males; 27.29?±?5.94 years old) who performed a Go/No-go task. The task involved two blocks with different proportions of No-go trials: Inhibition (25% No-go) and Vigilance (75% No-go). We compared whole-brain connectivity in the two groups during correct No-go trials in the Inhibition vs. Vigilance blocks between 0 and 400 ms. RESULTS: Despite comparable performance on the Go/No-go task, adults with ASD showed reduced connectivity compared to controls in the alpha band (8-14 Hz) in a network with a main hub in the right inferior frontal gyrus. Decreased connectivity in this network predicted more self-reported difficulties on a measure of inhibition in everyday life. LIMITATIONS: Measures of everyday inhibitory control were not available for all participants, so this relationship between reduced network connectivity and inhibitory control abilities may not be necessarily representative of all adults with ASD or the larger ASD population. Further research with independent samples of adults with ASD, including those with a wider range of cognitive abilities, would be valuable. CONCLUSIONS: Our findings demonstrate reduced functional brain connectivity during response inhibition in adults with ASD. As alpha-band synchrony has been linked to top-down control mechanisms, we propose that the lack of alpha synchrony observed in our ASD group may reflect difficulties in suppressing task-irrelevant information, interfering with inhibition in real-life situations. En ligne : http://dx.doi.org/10.1186/s13229-020-00400-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 An Exploratory Analysis of Predictors of Youth Suicide-Related Behaviors in Autism Spectrum Disorder: Implications for Prevention Science / Christina G. MCDONNELL in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
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Titre : An Exploratory Analysis of Predictors of Youth Suicide-Related Behaviors in Autism Spectrum Disorder: Implications for Prevention Science Type de document : Texte imprimé et/ou numérique Auteurs : Christina G. MCDONNELL, Auteur ; Elizabeth A. DELUCIA, Auteur ; Elizabeth P. HAYDEN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Xudong LIU, Auteur ; Ryan A. STEVENSON, Auteur Article en page(s) : p.3531-3544 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Prevention Psychopathology Suicidality Index. décimale : PER Périodiques Résumé : Although autism spectrum disorder (ASD) is associated with significant mental health concerns, little is known about suicidality, particularly among youth. To address this critical gap in the literature, the current study examined the predictive validity of (1) demographics, (2) core autism symptoms, (3) cognitive abilities and adaptive behavior, (4) comorbid psychopathology, and (5) medical problems, for suicide-related behaviors among autistic youth (N?=?481; M(age)?=?11.56 years). As indices of suicide-related behaviors, parents reported on whether the child had ever (1) talked about killing themselves, and (2) engaged in deliberate self-harm or attempted suicide. These two suicide-related outcomes had distinct clinical correlates, including child age, parental education, restricted and repetitive behaviors, IQ and adaptive behavior, affective and conduct problems, and medical concerns. En ligne : http://dx.doi.org/10.1007/s10803-019-04320-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3531-3544[article] An Exploratory Analysis of Predictors of Youth Suicide-Related Behaviors in Autism Spectrum Disorder: Implications for Prevention Science [Texte imprimé et/ou numérique] / Christina G. MCDONNELL, Auteur ; Elizabeth A. DELUCIA, Auteur ; Elizabeth P. HAYDEN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Rob NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Xudong LIU, Auteur ; Ryan A. STEVENSON, Auteur . - p.3531-3544.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3531-3544
Mots-clés : Autism spectrum disorder Prevention Psychopathology Suicidality Index. décimale : PER Périodiques Résumé : Although autism spectrum disorder (ASD) is associated with significant mental health concerns, little is known about suicidality, particularly among youth. To address this critical gap in the literature, the current study examined the predictive validity of (1) demographics, (2) core autism symptoms, (3) cognitive abilities and adaptive behavior, (4) comorbid psychopathology, and (5) medical problems, for suicide-related behaviors among autistic youth (N?=?481; M(age)?=?11.56 years). As indices of suicide-related behaviors, parents reported on whether the child had ever (1) talked about killing themselves, and (2) engaged in deliberate self-harm or attempted suicide. These two suicide-related outcomes had distinct clinical correlates, including child age, parental education, restricted and repetitive behaviors, IQ and adaptive behavior, affective and conduct problems, and medical concerns. En ligne : http://dx.doi.org/10.1007/s10803-019-04320-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 Assessing the validity of administrative health data for the identification of children and youth with autism spectrum disorder in Ontario / Jennifer D. BROOKS in Autism Research, 14-5 (May 2021)
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Titre : Assessing the validity of administrative health data for the identification of children and youth with autism spectrum disorder in Ontario Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer D. BROOKS, Auteur ; Jasleen ARNEJA, Auteur ; Longdi FU, Auteur ; Farah E. SAXENA, Auteur ; Karen TU, Auteur ; Virgiliu Bogdan PINZARU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Kirk NYLEN, Auteur ; Natasha R. SAUNDERS, Auteur ; Hong LU, Auteur ; John MCLAUGHLIN, Auteur ; Susan E. BRONSKILL, Auteur Article en page(s) : p.1037-1045 Langues : Anglais (eng) Mots-clés : Ontario administrative health data algorithm autism Index. décimale : PER Périodiques Résumé : Population-level identification of children and youth with ASD is essential for surveillance and planning for required services. The objective of this study was to develop and validate an algorithm for the identification of children and youth with ASD using administrative health data. In this retrospective validation study, we linked an electronic medical record (EMR)-based reference standard, consisting 10,000 individuals aged 1-24?years, including 112 confirmed ASD cases to Ontario administrative health data, for the testing of multiple case-finding algorithms. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and corresponding 95% confidence intervals (CI) were calculated for each algorithm. The optimal algorithm was validated in three external cohorts representing family practice, education, and specialized clinical settings. The optimal algorithm included an ASD diagnostic code for a single hospital discharge or emergency department visit or outpatient surgery, or three ASD physician billing codes in 3?years. This algorithm's sensitivity was 50.0% (95%CI 40.7-88.7%), specificity 99.6% (99.4-99.7), PPV 56.6% (46.8-66.3), and NPV 99.4% (99.3-99.6). The results of this study illustrate limitations and need for cautious interpretation when using administrative health data alone for the identification of children and youth with ASD. LAY SUMMARY: We tested algorithms (set of rules) to identify young people with ASD using routinely collected administrative health data. Even the best algorithm misses more than half of those in Ontario with ASD. To understand this better, we tested how well the algorithm worked in different settings (family practice, education, and specialized clinics). The identification of individuals with ASD at a population level is essential for planning for support services and the allocation of resources. Autism Res 2021, 14: 1037-1045. © 2021 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2491 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444
in Autism Research > 14-5 (May 2021) . - p.1037-1045[article] Assessing the validity of administrative health data for the identification of children and youth with autism spectrum disorder in Ontario [Texte imprimé et/ou numérique] / Jennifer D. BROOKS, Auteur ; Jasleen ARNEJA, Auteur ; Longdi FU, Auteur ; Farah E. SAXENA, Auteur ; Karen TU, Auteur ; Virgiliu Bogdan PINZARU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Kirk NYLEN, Auteur ; Natasha R. SAUNDERS, Auteur ; Hong LU, Auteur ; John MCLAUGHLIN, Auteur ; Susan E. BRONSKILL, Auteur . - p.1037-1045.
Langues : Anglais (eng)
in Autism Research > 14-5 (May 2021) . - p.1037-1045
Mots-clés : Ontario administrative health data algorithm autism Index. décimale : PER Périodiques Résumé : Population-level identification of children and youth with ASD is essential for surveillance and planning for required services. The objective of this study was to develop and validate an algorithm for the identification of children and youth with ASD using administrative health data. In this retrospective validation study, we linked an electronic medical record (EMR)-based reference standard, consisting 10,000 individuals aged 1-24?years, including 112 confirmed ASD cases to Ontario administrative health data, for the testing of multiple case-finding algorithms. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and corresponding 95% confidence intervals (CI) were calculated for each algorithm. The optimal algorithm was validated in three external cohorts representing family practice, education, and specialized clinical settings. The optimal algorithm included an ASD diagnostic code for a single hospital discharge or emergency department visit or outpatient surgery, or three ASD physician billing codes in 3?years. This algorithm's sensitivity was 50.0% (95%CI 40.7-88.7%), specificity 99.6% (99.4-99.7), PPV 56.6% (46.8-66.3), and NPV 99.4% (99.3-99.6). The results of this study illustrate limitations and need for cautious interpretation when using administrative health data alone for the identification of children and youth with ASD. LAY SUMMARY: We tested algorithms (set of rules) to identify young people with ASD using routinely collected administrative health data. Even the best algorithm misses more than half of those in Ontario with ASD. To understand this better, we tested how well the algorithm worked in different settings (family practice, education, and specialized clinics). The identification of individuals with ASD at a population level is essential for planning for support services and the allocation of resources. Autism Res 2021, 14: 1037-1045. © 2021 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2491 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology / Sakeena PANJU in Molecular Autism, (December 2015)
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Titre : Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (December 2015) . - p.1-10[article] Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology [Texte imprimé et/ou numérique] / Sakeena PANJU, Auteur ; Jessica BRIAN, Auteur ; Annie DUPUIS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Azadeh KUSHKI, Auteur . - p.1-10.
Langues : Anglais (eng)
in Molecular Autism > (December 2015) . - p.1-10
Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) has been associated with autonomic atypicalities, although the nature of these differences remains largely unknown. Moreover, existing literature suggests large variability in autonomic function in ASD, motivating the need to examine the existence of subgroups that exhibit more homogeneous autonomic features. En ligne : http://dx.doi.org/10.1186/s13229-015-0057-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Auditory-motor rhythm synchronization in children with autism spectrum disorder / Ana TRYFON in Research in Autism Spectrum Disorders, 35 (March 2017)
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PermalinkBrain and Language Associations in Autism Spectrum Disorder: A Scoping Review / C. A. CERMAK in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
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PermalinkBrief report: A confirmatory factor analysis of the Child Behavior Checklist in a large sample of autistic youth / Laura DE LA ROCHE in Research in Autism Spectrum Disorders, 118 (October 2024)
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PermalinkBrief Report: Parent Perspectives on Sensory-Based Interventions for Children with Autism Spectrum Disorder / M. PEÑA in Journal of Autism and Developmental Disorders, 51-6 (June 2021)
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PermalinkBrief Report: Repetitive Behaviours in Greek Individuals with Autism Spectrum Disorder / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 40-7 (July 2010)
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PermalinkCerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders / Elizabeth W. PANG in Autism Research, 16-3 (March 2023)
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PermalinkCharacterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample / Aneta D. KRAKOWSKI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
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PermalinkPermalinkConcurrent Validity of the ABAS-II Questionnaire with the Vineland II Interview for Adaptive Behavior in a Pediatric ASD Sample: High Correspondence Despite Systematically Lower Scores / Annie DUPUIS in Journal of Autism and Developmental Disorders, 51-5 (May 2021)
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PermalinkCRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions / Patricia SEGURA ; Louise GALLAGHER ; Stelios GEORGIADES ; Panagiota PERVANIDOU ; Audrey THURM ; Lindsay ALEXANDER ; Evdokia ANAGNOSTOU ; Yuta AOKI ; Catherine S. BIRKEN ; Somer L. BISHOP ; Jessica BOI ; Carmela BRAVACCIO ; Helena BRENTANI ; Paola CANEVINI ; Alessandra CARTA ; Alice CHARACH ; Antonella COSTANTINO ; Katherine T. COST ; Elaine A. CRAVO ; Jennifer CROSBIE ; Chiara DAVICO ; Federica DONNO ; Junya FUJINO ; Alessandra GABELLONE ; Cristiane T. GEYER ; Tomoya HIROTA ; Stephen KANNE ; Makiko KAWASHIMA ; Elizabeth KELLEY ; Hosanna KIM ; Young Shin KIM ; So Hyun KIM ; Daphne J. KORCZAK ; Meng-Chuan LAI ; Lucia MARGARI ; Lucia MARZULLI ; Gabriele MASI ; Luigi MAZZONE ; Jane MCGRATH ; Suneeta MONGA ; Paola MOROSINI ; Shinichiro NAKAJIMA ; Antonio NARZISI ; Rob NICOLSON ; Aki NIKOLAIDIS ; Yoshihiro NODA ; Kerri NOWELL ; Miriam POLIZZI ; Joana PORTOLESE ; Maria Pia RICCIO ; Manabu SAITO ; Ida SCHWARTZ ; Anish K. SIMHAL ; Martina SIRACUSANO ; Stefano SOTGIU ; Jacob STROUD ; Fernando SUMIYA ; Yoshiyuki TACHIBANA ; Nicole TAKAHASHI ; Riina TAKAHASHI ; Hiroki TAMON ; Raffaella TANCREDI ; Benedetto VITIELLO ; Alessandro ZUDDAS ; Bennett LEVENTHAL ; Kathleen MERIKANGAS ; Michael P. MILHAM ; Adriana DI MARTINO in Molecular Autism, 14 (2023)
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