Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis / Bonnie KLIMES-DOUGAN in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1321-1335 Titre : Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis Type de document : Texte imprimé et/ou numérique Auteurs : Bonnie KLIMES-DOUGAN, Auteur ; Lynn E. EBERLY, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Patrick KURKIEWICZ, Auteur ; Alaa HOURI, Auteur ; Amanda SCHLESINGER, Auteur ; Kathleen M. THOMAS, Auteur ; Bryon A. MUELLER, Auteur ; Kelvin O. LIM, Auteur ; Kathryn R. CULLEN, Auteur Année de publication : 2014 Article en page(s) : p.1321-1335 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12–19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts. En ligne : http://dx.doi.org/10.1017/S0954579414001059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Multilevel assessment of the neurobiological threat system in depressed adolescents: Interplay between the limbic system and hypothalamic–pituitary–adrenal axis [Texte imprimé et/ou numérique] / Bonnie KLIMES-DOUGAN, Auteur ; Lynn E. EBERLY, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Patrick KURKIEWICZ, Auteur ; Alaa HOURI, Auteur ; Amanda SCHLESINGER, Auteur ; Kathleen M. THOMAS, Auteur ; Bryon A. MUELLER, Auteur ; Kelvin O. LIM, Auteur ; Kathryn R. CULLEN, Auteur . - 2014 . - p.1321-1335. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1321-1335 Index. décimale : PER Périodiques Résumé : Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12–19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts. En ligne : http://dx.doi.org/10.1017/S0954579414001059 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury / Zeynep BA?GÖZE in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Titre : Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury Type de document : Texte imprimé et/ou numérique Auteurs : Zeynep BA?GÖZE, Auteur ; Salahudeen A. MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur Article en page(s) : p.1774-1792 Langues : Anglais (eng) Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury [Texte imprimé et/ou numérique] / Zeynep BA?GÖZE, Auteur ; Salahudeen A. MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur . - p.1774-1792. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

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