Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study / Ariel KARTEN in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1905-1914 Titre : Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study Type de document : Texte imprimé et/ou numérique Auteurs : Ariel KARTEN, Auteur ; Joy HIRSCH, Auteur Article en page(s) : p.1905-1914 Langues : Anglais (eng) Mots-clés : Functional magnetic resonance imaging (fMRI)  Functional connectivity  Psychophysiological interactions (PPI)  Negative BOLD response (NBR)  Neural inhibition  Autism  Receptive language processing Index. décimale : PER Périodiques Résumé : Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes. En ligne : http://dx.doi.org/10.1007/s10803-014-2344-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study [Texte imprimé et/ou numérique] / Ariel KARTEN, Auteur ; Joy HIRSCH, Auteur . - p.1905-1914. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1905-1914 Mots-clés : Functional magnetic resonance imaging (fMRI)  Functional connectivity  Psychophysiological interactions (PPI)  Negative BOLD response (NBR)  Neural inhibition  Autism  Receptive language processing Index. décimale : PER Périodiques Résumé : Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes. En ligne : http://dx.doi.org/10.1007/s10803-014-2344-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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