58 recherche sur le mot-clé 'Functional connectivity'

Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology / João F. Guassi MOREIRA ; Adriana S. MENDEZ LEAL ; Natalie M. SARAGOSA-HARRIS ; Elizabeth GAINES ; Wesley J. MEREDITH ; Yael WAIZMAN ; Emilia NINOVA ; Jennifer A. SILVERS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Titre : Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology Type de document : texte imprimé Auteurs : João F. Guassi MOREIRA, Auteur ; Adriana S. MENDEZ LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur Article en page(s) : p.1833-1845 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology [texte imprimé] / João F. Guassi MOREIRA, Auteur ; Adriana S. MENDEZ LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur . - p.1833-1845. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism / R. TUNG in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2100-2112 Titre : Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism Type de document : texte imprimé Auteurs : R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; Mikaela KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur Article en page(s) : p.2100-2112 Langues : Anglais (eng) Mots-clés : Adult  Anxiety/complications/diagnostic imaging  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder/complications/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Humans  Magnetic Resonance Imaging  Male  Middle Aged  Neural Pathways/diagnostic imaging  Asd  adults  anxiety  autism  functional connectivity  resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism [texte imprimé] / R. TUNG, Auteur ; M. A. REITER, Auteur ; A. LINKE, Auteur ; J. S. KOHLI, Auteur ; Mikaela KINNEAR, Auteur ; R. A. MULLER, Auteur ; Ruth A. CARPER, Auteur . - p.2100-2112. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2100-2112 Mots-clés : Adult  Anxiety/complications/diagnostic imaging  Autism Spectrum Disorder/complications/diagnostic imaging  Autistic Disorder/complications/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Humans  Magnetic Resonance Imaging  Male  Middle Aged  Neural Pathways/diagnostic imaging  Asd  adults  anxiety  autism  functional connectivity  resting state fMRI Index. décimale : PER Périodiques Résumé : Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and two studies on anxiety in ASDs. We tested for main effects of group and group by anxiety interactions on connectivity within this anxiety network, controlling for head motion using ANCOVA. Results are reported at an FDR adjusted threshold of q < 0.1 (corrected) and p < 0.05 (uncorrected). Adults with ASDs showed higher anxiety and underconnectivity within the anxiety network, mostly involving bilateral insula. Connectivity within the anxiety network in the ASD group showed distinct relationships with anxiety symptoms that did not relate to ASD symptom severity. Functional connectivity involving the bilateral posterior insula was positively correlated with anxiety in the ASD (but not the TC) group. Increased anxiety in middle-aged adults with ASD is associated with atypical functional connectivity, predominantly involving bilateral insula. Results were not related to ASD symptom severity suggesting independence of anxiety-related effects. LAY SUMMARY: Anxiety is very common in adults with autism but the brain basis of this difference is not well understood. We compared functional connectivity between anxiety-related brain regions in middle-aged adults with and without autism. Adults with autism were more anxious and showed weaker functional connections between these regions. Some relationships between functional connectivity and higher anxiety were specific to the autism group. Results suggest that anxiety functions differently in autism. En ligne : http://dx.doi.org/10.1002/aur.2579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study / J. O. MAXIMO in Autism Research, 12-3 (March 2019)  

Public ISBD [article]  inAutism Research > 12-3 (March 2019) . - p.384-400 Titre : Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study Type de document : texte imprimé Auteurs : J. O. MAXIMO, Auteur ; Rajesh K. KANA, Auteur Article en page(s) : p.384-400 Langues : Anglais (eng) Mots-clés : Asd  functional connectivity  subcortical  supramodal  unimodal Index. décimale : PER Périodiques Résumé : The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II). Resting-state functional magnetic resonance imaging data were used from 168 typically developing (TD) and 138 ASD participants across different sites from the ABIDE II dataset. Functional connectivity of basal ganglia and thalamus to unimodal and supramodal networks was examined in this study. Overconnectivity (ASD > TD) was found between unimodal (except for medial visual network) and subcortical regions, and underconnectivity (TD > ASD) was found between supramodal (except for default mode and dorsal attention networks) and subcortical regions; positive correlations between ASD phenotype and unimodal-subcortical connectivity were found and negative ones with supramodal-subcortical connectivity. These findings suggest that brain networks heavily involved in sensory processing had higher connectivity with subcortical regions, whereas those involved in higher-order thinking showed decreased connectivity in ASD. In addition, brain-behavior correlations indicated a relationship between ASD phenotype and connectivity. Thus, differences in cortico-subcortical connectivity may have a significant impact on basic and higher-order cognitive processes in ASD. Autism Res 2019, 12: 384-400 (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study focused on examining the functional connectivity (synchronization of brain activity across regions) of two types of brain networks (unimodal and supramodal) with subcortical areas (thalamus and basal ganglia) in children, adolescents, and adults with autism spectrum disorder (ASD) and how this relates to ASD phenotype. ASD participants showed overconnectivity in unimodal networks and underconnectivity in supramodal networks. These findings provide new insights into cortico-subcortical connections between basic sensory and high-order cognitive processes. En ligne : http://dx.doi.org/10.1002/aur.2058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] Aberrant "deep connectivity" in autism: A cortico-subcortical functional connectivity magnetic resonance imaging study [texte imprimé] / J. O. MAXIMO, Auteur ; Rajesh K. KANA, Auteur . - p.384-400. Langues : Anglais (eng) in Autism Research > 12-3 (March 2019) . - p.384-400 Mots-clés : Asd  functional connectivity  subcortical  supramodal  unimodal Index. décimale : PER Périodiques Résumé : The number of studies examining functional brain networks in Autism Spectrum Disorder (ASD) has risen over the last decade and has characterized ASD as a disorder of altered brain connectivity. However, these studies have focused largely on cortical structures, and only a few studies have examined cortico-subcortical connectivity in regions like thalamus and basal ganglia in ASD. The goal of this study was to characterize the functional connectivity between cortex and subcortical regions in ASD using the Autism Brain Imaging Data Exchange (ABIDE-II). Resting-state functional magnetic resonance imaging data were used from 168 typically developing (TD) and 138 ASD participants across different sites from the ABIDE II dataset. Functional connectivity of basal ganglia and thalamus to unimodal and supramodal networks was examined in this study. Overconnectivity (ASD > TD) was found between unimodal (except for medial visual network) and subcortical regions, and underconnectivity (TD > ASD) was found between supramodal (except for default mode and dorsal attention networks) and subcortical regions; positive correlations between ASD phenotype and unimodal-subcortical connectivity were found and negative ones with supramodal-subcortical connectivity. These findings suggest that brain networks heavily involved in sensory processing had higher connectivity with subcortical regions, whereas those involved in higher-order thinking showed decreased connectivity in ASD. In addition, brain-behavior correlations indicated a relationship between ASD phenotype and connectivity. Thus, differences in cortico-subcortical connectivity may have a significant impact on basic and higher-order cognitive processes in ASD. Autism Res 2019, 12: 384-400 (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study focused on examining the functional connectivity (synchronization of brain activity across regions) of two types of brain networks (unimodal and supramodal) with subcortical areas (thalamus and basal ganglia) in children, adolescents, and adults with autism spectrum disorder (ASD) and how this relates to ASD phenotype. ASD participants showed overconnectivity in unimodal networks and underconnectivity in supramodal networks. These findings provide new insights into cortico-subcortical connections between basic sensory and high-order cognitive processes. En ligne : http://dx.doi.org/10.1002/aur.2058 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder / W. VOORHIES in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1468-1478 Titre : Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder Type de document : texte imprimé Auteurs : W. VOORHIES, Auteur ; Dina R. DAJANI, Auteur ; S. G. VIJ, Auteur ; S. SHANKAR, Auteur ; T. O. TURAN, Auteur ; L. Q. UDDIN, Auteur Article en page(s) : p.1468-1478 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain development  functional connectivity  inhibitory control  resting-state fMRI Index. décimale : PER Périodiques Résumé : Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ-SPL and rIFJ-IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ-dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Autism Research 2018, 11: 1468-1478. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent-reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder. En ligne : http://dx.doi.org/10.1002/aur.2014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder [texte imprimé] / W. VOORHIES, Auteur ; Dina R. DAJANI, Auteur ; S. G. VIJ, Auteur ; S. SHANKAR, Auteur ; T. O. TURAN, Auteur ; L. Q. UDDIN, Auteur . - p.1468-1478. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1468-1478 Mots-clés : autism spectrum disorder  brain development  functional connectivity  inhibitory control  resting-state fMRI Index. décimale : PER Périodiques Résumé : Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ-SPL and rIFJ-IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ-dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Autism Research 2018, 11: 1468-1478. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent-reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder. En ligne : http://dx.doi.org/10.1002/aur.2014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder / Daniel VON RHEIN in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705 Titre : Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur Article en page(s) : p.697-705 Langues : Anglais (eng) Mots-clés : Resting-state fMRI  functional connectivity  attention-deficit/hyperactivity disorder  cortico-striatal networks  striatum  putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder [texte imprimé] / Daniel VON RHEIN, Auteur ; Marianne OLDEHINKEL, Auteur ; Christian F. BECKMANN, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Catharina A. HARTMAN, Auteur ; Pieter J. HOEKSTRA, Auteur ; Barbara FRANKE, Auteur ; Roshan COOLS, Auteur ; Jan K. BUITELAAR, Auteur ; Maarten MENNES, Auteur . - p.697-705. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.697-705 Mots-clés : Resting-state fMRI  functional connectivity  attention-deficit/hyperactivity disorder  cortico-striatal networks  striatum  putamen Index. décimale : PER Périodiques Résumé : Background Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children / C. E. ROGERS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder / Chen BAI in Autism Research, 16-6 (June 2023)  

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ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting / K. S. ROSCH in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

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Atypical longitudinal development of functional connectivity in adolescents with autism spectrum disorder / Katherine E. LAWRENCE in Autism Research, 12-1 (January 2019)  

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Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis / Jane MCGRATH in Autism Research, 5-5 (October 2012)  

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