Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood / Jill A. RABINOWITZ in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.703-718 Titre : Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood Type de document : texte imprimé Auteurs : Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion MAHER, Auteur Article en page(s) : p.703-718 Langues : Anglais (eng) Mots-clés : alcohol use classes  antisocial behavior polygenic risk score  community disadvantage  internalizing symptoms polygenic risk score  parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood [texte imprimé] / Jill A. RABINOWITZ, Auteur ; Rashelle J. MUSCI, Auteur ; Beth REBOUSSIN, Auteur ; Adam J. MILAM, Auteur ; Kelly S. BENKE, Auteur ; George R. UHL, Auteur ; Danielle Y. SISTO, Auteur ; Nicholas S. IALONGO, Auteur ; Brion MAHER, Auteur . - p.703-718. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.703-718 Mots-clés : alcohol use classes  antisocial behavior polygenic risk score  community disadvantage  internalizing symptoms polygenic risk score  parental monitoring Index. décimale : PER Périodiques Résumé : The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. En ligne : http://dx.doi.org/10.1017/s0954579419000701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth / Rashelle J. MUSCI in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.111-122 Titre : Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth Type de document : texte imprimé Auteurs : Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; George UHL, Auteur ; Brion MAHER, Auteur ; Sheppard G. KELLAM, Auteur ; Nicholas S. IALONGO, Auteur Article en page(s) : p.111-122 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examines the interaction between a polygenic score and an elementary school-based universal preventive intervention trial. The polygenic score reflects the contribution of multiple genes and has been shown in prior research to be predictive of smoking cessation and tobacco use (Uhl et al., 2014). Using data from a longitudinal preventive intervention study, we examined age of first tobacco use from sixth grade to age 18. Genetic data were collected during emerging adulthood and were genotyped using the Affymetrix 6.0 microarray. The polygenic score was computed using these data. Discrete-time survival analysis was employed to test for intervention main and interaction effects with the polygenic score. We found a main effect of the intervention, with the intervention participants reporting their first cigarette smoked at an age significantly later than controls. We also found an Intervention × Polygenic Score interaction, with participants at the higher end of the polygenic score benefitting the most from the intervention in terms of delayed age of first use. These results are consistent with Belsky and colleagues' (e.g., Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2007; Belsky & Pleuss, 2009, 2013; Ellis, Boyce, Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2011) differential susceptibility hypothesis and the concept of “for better or worse,” wherein the expression of genetic variants are optimally realized in the context of an enriched environment, such as provided by a preventive intervention. En ligne : http://dx.doi.org/10.1017/S0954579414001333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth [texte imprimé] / Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; George UHL, Auteur ; Brion MAHER, Auteur ; Sheppard G. KELLAM, Auteur ; Nicholas S. IALONGO, Auteur . - p.111-122. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.111-122 Index. décimale : PER Périodiques Résumé : The present study examines the interaction between a polygenic score and an elementary school-based universal preventive intervention trial. The polygenic score reflects the contribution of multiple genes and has been shown in prior research to be predictive of smoking cessation and tobacco use (Uhl et al., 2014). Using data from a longitudinal preventive intervention study, we examined age of first tobacco use from sixth grade to age 18. Genetic data were collected during emerging adulthood and were genotyped using the Affymetrix 6.0 microarray. The polygenic score was computed using these data. Discrete-time survival analysis was employed to test for intervention main and interaction effects with the polygenic score. We found a main effect of the intervention, with the intervention participants reporting their first cigarette smoked at an age significantly later than controls. We also found an Intervention × Polygenic Score interaction, with participants at the higher end of the polygenic score benefitting the most from the intervention in terms of delayed age of first use. These results are consistent with Belsky and colleagues' (e.g., Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2007; Belsky & Pleuss, 2009, 2013; Ellis, Boyce, Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2011) differential susceptibility hypothesis and the concept of “for better or worse,” wherein the expression of genetic variants are optimally realized in the context of an enriched environment, such as provided by a preventive intervention. En ligne : http://dx.doi.org/10.1017/S0954579414001333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence / Rashelle J. MUSCI in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.225-237 Titre : The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence Type de document : texte imprimé Auteurs : Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur Article en page(s) : p.225-237 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence [texte imprimé] / Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur . - p.225-237. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.225-237 Index. décimale : PER Périodiques Résumé : Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors / Rashelle J. MUSCI in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.72-81 Titre : Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors Type de document : texte imprimé Auteurs : Rashelle J. MUSCI, Auteur ; Amie F. BETTENCOURT, Auteur ; Danielle SISTO, Auteur ; Brion MAHER, Auteur ; Katherine E. MASYN, Auteur ; Nicholas S. IALONGO, Auteur Article en page(s) : p.72-81 Langues : Anglais (eng) Mots-clés : Aggression  genetics  molecular  violence Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research has demonstrated a reciprocal relationship between community violence exposure and disruptive behavior problems among youth. No study to date, however, has explored the potential interaction between violence exposure in early adolescence and genetics. METHODS: We explore the gene x environment interaction's impact on teacher-rated aggressive and impulsive behaviors. Violence exposure during the middle school years was assessed using self-report. Genetic data collection occurred in emerging adulthood. A polygenic score was created using findings from a conduct disorder symptomatology genome-wide association study. RESULTS: Three longitudinal classes of teacher reported aggressive and impulsive behavior were identified. We found a significant relationship between violence exposure and class membership. There was a significant GxE interaction, such that those with below average levels of the polygenic score and who were exposed to violence were more likely to be in the moderately high aggressive and impulsive class as compared to the no to low class. CONCLUSIONS: These findings highlight the influence of genetic risk together with violence exposure on adolescent problem behavior. Although youth may have little control over the environments in which they live, interventions can and should focus on helping all youth. En ligne : http://dx.doi.org/10.1111/jcpp.12966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374 [article] Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors [texte imprimé] / Rashelle J. MUSCI, Auteur ; Amie F. BETTENCOURT, Auteur ; Danielle SISTO, Auteur ; Brion MAHER, Auteur ; Katherine E. MASYN, Auteur ; Nicholas S. IALONGO, Auteur . - p.72-81. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-1 (January 2019) . - p.72-81 Mots-clés : Aggression  genetics  molecular  violence Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research has demonstrated a reciprocal relationship between community violence exposure and disruptive behavior problems among youth. No study to date, however, has explored the potential interaction between violence exposure in early adolescence and genetics. METHODS: We explore the gene x environment interaction's impact on teacher-rated aggressive and impulsive behaviors. Violence exposure during the middle school years was assessed using self-report. Genetic data collection occurred in emerging adulthood. A polygenic score was created using findings from a conduct disorder symptomatology genome-wide association study. RESULTS: Three longitudinal classes of teacher reported aggressive and impulsive behavior were identified. We found a significant relationship between violence exposure and class membership. There was a significant GxE interaction, such that those with below average levels of the polygenic score and who were exposed to violence were more likely to be in the moderately high aggressive and impulsive class as compared to the no to low class. CONCLUSIONS: These findings highlight the influence of genetic risk together with violence exposure on adolescent problem behavior. Although youth may have little control over the environments in which they live, interventions can and should focus on helping all youth. En ligne : http://dx.doi.org/10.1111/jcpp.12966 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=374

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