Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth / Rashelle J. MUSCI in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.111-122 Titre : Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth Type de document : Texte imprimé et/ou numérique Auteurs : Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; George UHL, Auteur ; Brion MAHER, Auteur ; Sheppard G. KELLAM, Auteur ; Nicholas S. IALONGO, Auteur Article en page(s) : p.111-122 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examines the interaction between a polygenic score and an elementary school-based universal preventive intervention trial. The polygenic score reflects the contribution of multiple genes and has been shown in prior research to be predictive of smoking cessation and tobacco use (Uhl et al., 2014). Using data from a longitudinal preventive intervention study, we examined age of first tobacco use from sixth grade to age 18. Genetic data were collected during emerging adulthood and were genotyped using the Affymetrix 6.0 microarray. The polygenic score was computed using these data. Discrete-time survival analysis was employed to test for intervention main and interaction effects with the polygenic score. We found a main effect of the intervention, with the intervention participants reporting their first cigarette smoked at an age significantly later than controls. We also found an Intervention × Polygenic Score interaction, with participants at the higher end of the polygenic score benefitting the most from the intervention in terms of delayed age of first use. These results are consistent with Belsky and colleagues' (e.g., Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2007; Belsky & Pleuss, 2009, 2013; Ellis, Boyce, Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2011) differential susceptibility hypothesis and the concept of “for better or worse,” wherein the expression of genetic variants are optimally realized in the context of an enriched environment, such as provided by a preventive intervention. En ligne : http://dx.doi.org/10.1017/S0954579414001333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Polygenic Score × Intervention Moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth [Texte imprimé et/ou numérique] / Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; George UHL, Auteur ; Brion MAHER, Auteur ; Sheppard G. KELLAM, Auteur ; Nicholas S. IALONGO, Auteur . - p.111-122. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.111-122 Index. décimale : PER Périodiques Résumé : The present study examines the interaction between a polygenic score and an elementary school-based universal preventive intervention trial. The polygenic score reflects the contribution of multiple genes and has been shown in prior research to be predictive of smoking cessation and tobacco use (Uhl et al., 2014). Using data from a longitudinal preventive intervention study, we examined age of first tobacco use from sixth grade to age 18. Genetic data were collected during emerging adulthood and were genotyped using the Affymetrix 6.0 microarray. The polygenic score was computed using these data. Discrete-time survival analysis was employed to test for intervention main and interaction effects with the polygenic score. We found a main effect of the intervention, with the intervention participants reporting their first cigarette smoked at an age significantly later than controls. We also found an Intervention × Polygenic Score interaction, with participants at the higher end of the polygenic score benefitting the most from the intervention in terms of delayed age of first use. These results are consistent with Belsky and colleagues' (e.g., Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2007; Belsky & Pleuss, 2009, 2013; Ellis, Boyce, Belsky, Bakermans-Kranenburg, & van IJzendoorn, 2011) differential susceptibility hypothesis and the concept of “for better or worse,” wherein the expression of genetic variants are optimally realized in the context of an enriched environment, such as provided by a preventive intervention. En ligne : http://dx.doi.org/10.1017/S0954579414001333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence / Rashelle J. MUSCI in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.225-237 Titre : The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur Article en page(s) : p.225-237 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence [Texte imprimé et/ou numérique] / Rashelle J. MUSCI, Auteur ; Katherine E. MASYN, Auteur ; Kelly S. BENKE, Auteur ; Brion MAHER, Auteur ; George UHL, Auteur ; Nicholas S. IALONGO, Auteur . - p.225-237. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.225-237 Index. décimale : PER Périodiques Résumé : Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence. En ligne : http://dx.doi.org/10.1017/S0954579415000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

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