[article] 
inJournal of Child Psychology and Psychiatry > 58-4 (April 2017) . - p.411-435

Titre :	Annual Research Review: Understudied populations within the autism spectrum – current trends and future directions in neuroimaging research
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Allison JACK, Auteur ; Kevin A. PELPHREY, Auteur
Article en page(s) :	p.411-435
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorders  intellectual disability  neuroimaging
Index. décimale :	PER Périodiques
Résumé :	Background Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD + ID), autism with a history of developmental regression (ASD + R), and minimally verbal autism (ASD + MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes. Scope and methodology This review evaluates existing neuroimaging research on ASD + MV, ASD + ID, and ASD + R, identified by a search of the literature using the PubMed database, and discusses methodological, theoretical, and practical considerations for future research involving neuroimaging assessment of these populations. Findings There is a paucity of neuroimaging research on ASD + ID, ASD + MV, and ASD + R, and what findings do exist are often contradictory, or so sparse as to be ungeneralizable. We suggest that while greater sample sizes and more studies are necessary, more important would be a paradigm shift toward multimodal (e.g. imaging genetics) approaches that allow for the characterization of heterogeneity within etiologically diverse samples.
En ligne :	http://dx.doi.org/10.1111/jcpp.12687
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

[article] Annual Research Review: Understudied populations within the autism spectrum – current trends and future directions in neuroimaging research [Texte imprimé et/ou numérique] / Allison JACK, Auteur ; Kevin A. PELPHREY, Auteur . - p.411-435.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-4 (April 2017) . - p.411-435

Mots-clés :	Autism spectrum disorders  intellectual disability  neuroimaging
Index. décimale :	PER Périodiques
Résumé :	Background Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD + ID), autism with a history of developmental regression (ASD + R), and minimally verbal autism (ASD + MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes. Scope and methodology This review evaluates existing neuroimaging research on ASD + MV, ASD + ID, and ASD + R, identified by a search of the literature using the PubMed database, and discusses methodological, theoretical, and practical considerations for future research involving neuroimaging assessment of these populations. Findings There is a paucity of neuroimaging research on ASD + ID, ASD + MV, and ASD + R, and what findings do exist are often contradictory, or so sparse as to be ungeneralizable. We suggest that while greater sample sizes and more studies are necessary, more important would be a paradigm shift toward multimodal (e.g. imaging genetics) approaches that allow for the characterization of heterogeneity within etiologically diverse samples.
En ligne :	http://dx.doi.org/10.1111/jcpp.12687
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305