[article] 
inDevelopment and Psychopathology > 29-2 (May 2017) . - p.505-518

Titre :	Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Sandra THIJSSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Vincent W.V. JADDOE, Auteur ; Henning TIEMEIER, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur
Article en page(s) :	p.505-518
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	This study examined whether the association between age and amygdala–medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables. Higher level analyses assessing Sensitivity × Age as well as exploratory Sensitivity × Age × Gender interaction effects were performed restricted to voxels in the mPFC. We found significant Sensitivity × Age interaction effects on amygdala–mPFC connectivity. Age was related to stronger amygdala–mPFC connectivity in children with a lower combined parental sensitivity score (b = 0.11, p = .004, b = 0.06, p = .06, right and left amygdala, respectively), but not in children with a higher parental sensitivity score, (b = –0.07, p = .12, b = –0.06, p = .12, right and left amygdala, respectively). A similar effect was found for maternal sensitivity, with stronger amygdala–mPFC connectivity in children with less sensitive mothers. Exploratory (parental, maternal, paternal) Sensitivity × Age × Gender interaction analyses suggested that this effect was especially pronounced in girls. Amygdala-mPFC resting-state functional connectivity has been shown to increase from age 10.5 years onward, implying that the positive association between age and amygdala–mPFC connectivity in 6- to 10-year-old children of less sensitive parents represents accelerated development of the amygdala–mPFC circuit.
En ligne :	http://dx.doi.org/10.1017/s0954579417000141
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

[article] Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Ryan L. MUETZEL, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Vincent W.V. JADDOE, Auteur ; Henning TIEMEIER, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur . - p.505-518.
Langues : Anglais (eng)
in Development and Psychopathology > 29-2 (May 2017) . - p.505-518

Index. décimale :	PER Périodiques
Résumé :	This study examined whether the association between age and amygdala–medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables. Higher level analyses assessing Sensitivity × Age as well as exploratory Sensitivity × Age × Gender interaction effects were performed restricted to voxels in the mPFC. We found significant Sensitivity × Age interaction effects on amygdala–mPFC connectivity. Age was related to stronger amygdala–mPFC connectivity in children with a lower combined parental sensitivity score (b = 0.11, p = .004, b = 0.06, p = .06, right and left amygdala, respectively), but not in children with a higher parental sensitivity score, (b = –0.07, p = .12, b = –0.06, p = .12, right and left amygdala, respectively). A similar effect was found for maternal sensitivity, with stronger amygdala–mPFC connectivity in children with less sensitive mothers. Exploratory (parental, maternal, paternal) Sensitivity × Age × Gender interaction analyses suggested that this effect was especially pronounced in girls. Amygdala-mPFC resting-state functional connectivity has been shown to increase from age 10.5 years onward, implying that the positive association between age and amygdala–mPFC connectivity in 6- to 10-year-old children of less sensitive parents represents accelerated development of the amygdala–mPFC circuit.
En ligne :	http://dx.doi.org/10.1017/s0954579417000141
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305