Adolescent gender diversity: sociodemographic correlates and mental health outcomes in the general population / Akhgar GHASSABIAN in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1415-1422 Titre : Adolescent gender diversity: sociodemographic correlates and mental health outcomes in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Akhgar GHASSABIAN, Auteur ; Anna SULERI, Auteur ; Elisabet BLOK, Auteur ; Berta FRANCH, Auteur ; Manon H. J. HILLEGERS, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.1415-1422 Langues : Anglais (eng) Mots-clés : Child  Infant, Newborn  Humans  Adolescent  Male  Female  Gender Identity  Parents/psychology  Mental Health  Anxiety  Outcome Assessment, Health Care  Gender-variant  autistic traits  general population Index. décimale : PER Périodiques Résumé : BACKGROUND: Gender diversity in young adolescents is understudied outside of referral clinics. We investigated gender diversity in an urban, ethnically diverse sample of adolescents from the general population and examined predictors and associated mental health outcomes. METHODS: The study was embedded in Generation R, a population-based cohort of children born between 2002 and 2006 in Rotterdam, the Netherlands (n=5727). At ages 9-11 and 13-15 years, adolescents and/or their parents responded to two questions addressing children's contentedness with their assigned gender, whether they (a) 'wished to be the opposite sex' and (b) 'would rather be treated as someone from the opposite sex'. We defined 'gender-variant experience' when either the parent or child responded with 'somewhat or sometimes true' or 'very or often true'. Mental health was assessed at 13-15 years, using the Achenbach System of Empirically Based Assessment. RESULTS: Less than 1% of the parents reported that their child had gender-variant experience, with poor stability between 9-11 and 13-15 years. In contrast, 4% of children reported gender-variant experience at 13-15 years. Adolescents who were assigned female at birth reported more gender-variant experience than those assigned male. Parents with low/medium educational levels reported more gender-variant experience in their children than those with higher education. There were positive associations between gender-variant experience and symptoms of anxiety, depression, somatic complaints, rule-breaking, and aggressive behavior as well as attention, social, and thought problems. Similar associations were observed for autistic traits, independent of other mental difficulties. These associations did not differ by assigned sex at birth. CONCLUSIONS: Within this population-based study, adolescents assigned females were more likely to have gender-variant experience than males. Our data suggest that parents may not be aware of gender diversity feelings in their adolescents. Associations between gender diversity and mental health symptoms were present in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13588 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Adolescent gender diversity: sociodemographic correlates and mental health outcomes in the general population [Texte imprimé et/ou numérique] / Akhgar GHASSABIAN, Auteur ; Anna SULERI, Auteur ; Elisabet BLOK, Auteur ; Berta FRANCH, Auteur ; Manon H. J. HILLEGERS, Auteur ; Tonya WHITE, Auteur . - p.1415-1422. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1415-1422 Mots-clés : Child  Infant, Newborn  Humans  Adolescent  Male  Female  Gender Identity  Parents/psychology  Mental Health  Anxiety  Outcome Assessment, Health Care  Gender-variant  autistic traits  general population Index. décimale : PER Périodiques Résumé : BACKGROUND: Gender diversity in young adolescents is understudied outside of referral clinics. We investigated gender diversity in an urban, ethnically diverse sample of adolescents from the general population and examined predictors and associated mental health outcomes. METHODS: The study was embedded in Generation R, a population-based cohort of children born between 2002 and 2006 in Rotterdam, the Netherlands (n=5727). At ages 9-11 and 13-15 years, adolescents and/or their parents responded to two questions addressing children's contentedness with their assigned gender, whether they (a) 'wished to be the opposite sex' and (b) 'would rather be treated as someone from the opposite sex'. We defined 'gender-variant experience' when either the parent or child responded with 'somewhat or sometimes true' or 'very or often true'. Mental health was assessed at 13-15 years, using the Achenbach System of Empirically Based Assessment. RESULTS: Less than 1% of the parents reported that their child had gender-variant experience, with poor stability between 9-11 and 13-15 years. In contrast, 4% of children reported gender-variant experience at 13-15 years. Adolescents who were assigned female at birth reported more gender-variant experience than those assigned male. Parents with low/medium educational levels reported more gender-variant experience in their children than those with higher education. There were positive associations between gender-variant experience and symptoms of anxiety, depression, somatic complaints, rule-breaking, and aggressive behavior as well as attention, social, and thought problems. Similar associations were observed for autistic traits, independent of other mental difficulties. These associations did not differ by assigned sex at birth. CONCLUSIONS: Within this population-based study, adolescents assigned females were more likely to have gender-variant experience than males. Our data suggest that parents may not be aware of gender diversity feelings in their adolescents. Associations between gender diversity and mental health symptoms were present in adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13588 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Cognitive performance in children and adolescents with psychopathology traits: A cross-sectional multicohort study in the general population / Elisabet BLOK in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.926-940 Titre : Cognitive performance in children and adolescents with psychopathology traits: A cross-sectional multicohort study in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Elisabet BLOK, Auteur ; Isabel K. SCHUURMANS, Auteur ; Anne J. TIJBURG, Auteur ; Manon HILLEGERS, Auteur ; Maria E. KOOPMAN-VERHOEFF, Auteur ; Ryan L. MUETZEL, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.926-940 Langues : Anglais (eng) Mots-clés : adolescence  childhood  cognition  Child Behavior Checklist  psychopathology Index. décimale : PER Périodiques Résumé : Psychopathology and cognitive development are closely related. Assessing the relationship between multiple domains of psychopathology and cognitive performance can elucidate which cognitive tasks are related to specific domains of psychopathology. This can help build theory and improve clinical decision-making in the future. In this study, we included 13,841 children and adolescents drawn from two large population-based samples (Generation R and ABCD studies). We assessed the cross-sectional relationship between three psychopathology domains (internalizing, externalizing, dysregulation profile (DP)) and four cognitive domains (vocabulary, fluid reasoning, working memory, and processing speed) and the full-scale intelligence quotient. Lastly, differential associations between symptoms of psychopathology and cognitive performance by sex were assessed. Results indicated that internalizing symptoms were related to worse performance in working memory and processing speed, but better performance in the verbal domain. Externalizing and DP symptoms were related to poorer global cognitive performance. Notably, those in the DP subgroup had a 5.0 point lower IQ than those without behavioral problems. Cognitive performance was more heavily affected in boys than in girls given comparable levels of psychopathology. Taken together, we provide evidence for globally worse cognitive performance in children and adolescents with externalizing and DP symptoms, with those in the DP subgroup being most heavily affected. En ligne : http://dx.doi.org/10.1017/S0954579422000165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Cognitive performance in children and adolescents with psychopathology traits: A cross-sectional multicohort study in the general population [Texte imprimé et/ou numérique] / Elisabet BLOK, Auteur ; Isabel K. SCHUURMANS, Auteur ; Anne J. TIJBURG, Auteur ; Manon HILLEGERS, Auteur ; Maria E. KOOPMAN-VERHOEFF, Auteur ; Ryan L. MUETZEL, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur . - p.926-940. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.926-940 Mots-clés : adolescence  childhood  cognition  Child Behavior Checklist  psychopathology Index. décimale : PER Périodiques Résumé : Psychopathology and cognitive development are closely related. Assessing the relationship between multiple domains of psychopathology and cognitive performance can elucidate which cognitive tasks are related to specific domains of psychopathology. This can help build theory and improve clinical decision-making in the future. In this study, we included 13,841 children and adolescents drawn from two large population-based samples (Generation R and ABCD studies). We assessed the cross-sectional relationship between three psychopathology domains (internalizing, externalizing, dysregulation profile (DP)) and four cognitive domains (vocabulary, fluid reasoning, working memory, and processing speed) and the full-scale intelligence quotient. Lastly, differential associations between symptoms of psychopathology and cognitive performance by sex were assessed. Results indicated that internalizing symptoms were related to worse performance in working memory and processing speed, but better performance in the verbal domain. Externalizing and DP symptoms were related to poorer global cognitive performance. Notably, those in the DP subgroup had a 5.0 point lower IQ than those without behavioral problems. Cognitive performance was more heavily affected in boys than in girls given comparable levels of psychopathology. Taken together, we provide evidence for globally worse cognitive performance in children and adolescents with externalizing and DP symptoms, with those in the DP subgroup being most heavily affected. En ligne : http://dx.doi.org/10.1017/S0954579422000165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study / Masoud AMIRI in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1582-1600 Titre : Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M. E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.1582-1600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Environment-Wide Association Study (EnWAS) of Prenatal and Perinatal Factors Associated With Autistic Traits: A Population-Based Study [Texte imprimé et/ou numérique] / Masoud AMIRI, Auteur ; Sander LAMBALLAIS, Auteur ; Eloy GEENJAAR, Auteur ; Laura M. E. BLANKEN, Auteur ; Hanan EL MARROUN, Auteur ; Henning TIEMEIER, Auteur ; Tonya WHITE, Auteur . - p.1582-1600. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1582-1600 Index. décimale : PER Périodiques Résumé : Abstract A combination of genetic and environmental factors contributes to the origins of autism spectrum disorder (ASD). While a number of studies have described specific environmental factors associating with emerging ASD, studies that compare and contrast multiple environmental factors in the same study are lacking. Thus, the goal of this study was to perform a prospective, data-driven environmental-wide association study of pre- and perinatal factors associated with the later development of autistic symptoms in childhood. The participants included 3891 6-year-old children from a birth cohort with pre- and perinatal data. Autistic symptoms were measured using the Social Responsiveness Scale in all children. Prior to any analyses, the sample was randomly split into a discovery set (2920) and a test set (921). Multiple linear regression analyses were performed for each of 920 variables, correcting for six of the most common covariates in epidemiological studies. We found 111 different pre- and perinatal factors associated with autistic traits during childhood. In secondary analyses where we controlled for parental psychopathology, 23 variables in the domains of family and interpersonal relationships were associated with the development of autistic symptoms during childhood. In conclusion, a data-driven approach was used to identify a number of pre- and perinatal risk factors associating with higher childhood autistic symptoms. These factors include measures of parental psychopathology and family and interpersonal relationships. These measures could potentially be used for the early identification of those at increased risk to develop ASD. Lay Summary A combination of genetic and environmental factors contributes to the development of autism spectrum disorder (ASD). Each environmental factor may affect the risk of ASD. In a study on 6-year-old children, a number of pre- and perinatal risk factors were identified that are associated with autistic symptoms in childhood. These factors include measures of parental psychopathology and family and interpersonal relationships. These variables could potentially serve as markers to identify those at increased risk to develop ASD or autistic symptoms. Autism Res 2020, 13: 1582–1600. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Gyrification and neural connectivity in schizophrenia / Tonya WHITE in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.339-352 Titre : Gyrification and neural connectivity in schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Tonya WHITE, Auteur ; Claus C. HILGETAG, Auteur Année de publication : 2011 Article en page(s) : p.339-352 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is emerging evidence for a connection between the surface morphology of the brain and its underlying connectivity. The foundation for this relationship is thought to be established during brain development through the shaping influences of tension exerted by viscoelastic nerve fibers. The tension-based morphogenesis results in compact wiring that enhances efficient neural processing. Individuals with schizophrenia present with multiple symptoms that can include impaired thought, action, perception, and cognition. The global nature of these symptoms has led researchers to explore a more global disruption of neuronal connectivity as a theory to explain the vast array of clinical and cognitive symptoms in schizophrenia. If cerebral function and form are linked through the organization of neural connectivity, then a disruption in neural connectivity may also alter the surface morphology of the brain. This paper reviews developmental theories of gyrification and the potential interaction between gyrification and neuronal connectivity. Studies of gyrification abnormalities in children, adolescents, and adults with schizophrenia demonstrate a relationship between disrupted function and altered morphology in the surface patterns of the cerebral cortex. This altered form may provide helpful clues in understanding the neurobiological abnormalities associated with schizophrenia. En ligne : http://dx.doi.org/10.1017/S0954579410000842 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Gyrification and neural connectivity in schizophrenia [Texte imprimé et/ou numérique] / Tonya WHITE, Auteur ; Claus C. HILGETAG, Auteur . - 2011 . - p.339-352. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.339-352 Index. décimale : PER Périodiques Résumé : There is emerging evidence for a connection between the surface morphology of the brain and its underlying connectivity. The foundation for this relationship is thought to be established during brain development through the shaping influences of tension exerted by viscoelastic nerve fibers. The tension-based morphogenesis results in compact wiring that enhances efficient neural processing. Individuals with schizophrenia present with multiple symptoms that can include impaired thought, action, perception, and cognition. The global nature of these symptoms has led researchers to explore a more global disruption of neuronal connectivity as a theory to explain the vast array of clinical and cognitive symptoms in schizophrenia. If cerebral function and form are linked through the organization of neural connectivity, then a disruption in neural connectivity may also alter the surface morphology of the brain. This paper reviews developmental theories of gyrification and the potential interaction between gyrification and neuronal connectivity. Studies of gyrification abnormalities in children, adolescents, and adults with schizophrenia demonstrate a relationship between disrupted function and altered morphology in the surface patterns of the cerebral cortex. This altered form may provide helpful clues in understanding the neurobiological abnormalities associated with schizophrenia. En ligne : http://dx.doi.org/10.1017/S0954579410000842 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study / Akhgar GHASSABIAN in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104 Titre : Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : 96-104 Langues : Anglais (eng) Mots-clés : Brain  corpus callosum  executive function  Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study [Texte imprimé et/ou numérique] / Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - 96-104. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104 Mots-clés : Brain  corpus callosum  executive function  Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

Infant muscle tone and childhood autistic traits: A longitudinal study in the general population / Fadila SERDAREVIC in Autism Research, 10-5 (May 2017)  

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Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit / Sandra THIJSSEN in Development and Psychopathology, 29-2 (May 2017)  

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Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort / Novika Purnama SARI in Molecular Autism, 13 (2022)  

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Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population / Philip R. JANSEN in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)  

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The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study / Melisa DURKUT in Molecular Autism, 13 (2022)  

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