Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups / Tayo OBAFEMI-AJAYI in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1302-1317 Titre : Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups Type de document : texte imprimé Auteurs : Tayo OBAFEMI-AJAYI, Auteur ; Judith H. MILES, Auteur ; T. Nicole TAKAHASHI, Auteur ; Wenchuan QI, Auteur ; Kristina ALDRIDGE, Auteur ; Minqi ZHANG, Auteur ; Shi-Qing XIN, Auteur ; Ying HE, Auteur ; Ye DUAN, Auteur Article en page(s) : p.1302-1317 Langues : Anglais (eng) Mots-clés : Autism  Cluster analysis  Language regression  Facial phenotype  Biomarker  Outcome indicators Index. décimale : PER Périodiques Résumé : Varied cluster analysis were applied to facial surface measurements from 62 prepubertal boys with essential autism to determine whether facial morphology constitutes viable biomarker for delineation of discrete Autism Spectrum Disorders (ASD) subgroups. Earlier study indicated utility of facial morphology for autism subgrouping (Aldridge et al. in Mol Autism 2(1):15, 2011). Geodesic distances between standardized facial landmarks were measured from three-dimensional stereo-photogrammetric images. Subjects were evaluated for autism-related symptoms, neurologic, cognitive, familial, and phenotypic variants. The most compact cluster is clinically characterized by severe ASD, significant cognitive impairment and language regression. This verifies utility of facially-based ASD subtypes and validates Aldridge et al.’s severe ASD subgroup, notwithstanding different techniques. It suggests that language regression may define a unique ASD subgroup with potential etiologic differences. En ligne : http://dx.doi.org/10.1007/s10803-014-2290-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups [texte imprimé] / Tayo OBAFEMI-AJAYI, Auteur ; Judith H. MILES, Auteur ; T. Nicole TAKAHASHI, Auteur ; Wenchuan QI, Auteur ; Kristina ALDRIDGE, Auteur ; Minqi ZHANG, Auteur ; Shi-Qing XIN, Auteur ; Ying HE, Auteur ; Ye DUAN, Auteur . - p.1302-1317. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1302-1317 Mots-clés : Autism  Cluster analysis  Language regression  Facial phenotype  Biomarker  Outcome indicators Index. décimale : PER Périodiques Résumé : Varied cluster analysis were applied to facial surface measurements from 62 prepubertal boys with essential autism to determine whether facial morphology constitutes viable biomarker for delineation of discrete Autism Spectrum Disorders (ASD) subgroups. Earlier study indicated utility of facial morphology for autism subgrouping (Aldridge et al. in Mol Autism 2(1):15, 2011). Geodesic distances between standardized facial landmarks were measured from three-dimensional stereo-photogrammetric images. Subjects were evaluated for autism-related symptoms, neurologic, cognitive, familial, and phenotypic variants. The most compact cluster is clinically characterized by severe ASD, significant cognitive impairment and language regression. This verifies utility of facially-based ASD subtypes and validates Aldridge et al.’s severe ASD subgroup, notwithstanding different techniques. It suggests that language regression may define a unique ASD subgroup with potential etiologic differences. En ligne : http://dx.doi.org/10.1007/s10803-014-2290-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Psychological resilience moderates the relationship between childhood adversity, brain network connectivity, and wellness / Yuanyuan LI in Development and Psychopathology, 38-4 (October 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-4 (October 2026) . - p.1774-1782 Titre : Psychological resilience moderates the relationship between childhood adversity, brain network connectivity, and wellness Type de document : texte imprimé Auteurs : Yuanyuan LI, Auteur ; Zelin LIU, Auteur ; Bowen HU, Auteur ; Jiahua XU, Auteur ; Jiale XIAO, Auteur ; Boxuan CHEN, Auteur ; Ting TIAN, Auteur ; Ying HE, Auteur ; Shaozheng QIN, Auteur ; Danhua LIN, Auteur Article en page(s) : p.1774-1782 Langues : Anglais (eng) Mots-clés : brain network  childhood adversity  dimensional perspective  psychological resilience  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : Childhood adversity impairs well-being, yet psychological resilience may buffer its impact. Using resting-state fMRI in 94 rural Chinese children (ages 10–14), we examined whether psychological resilience protects brain network connectivity from adversity and its relevance to psychological well-being. Psychological resilience significantly moderated the impact of abuse, but not neglect, on limbic connectivity. Low-resilience children exposed to abuse showed heightened limbic-somatomotor and limbic-ventral attention connectivity, which predicted greater somatization and depression at baseline and more severe levels of anxiety six months later. These associations were absent in high-resilience children. Our findings reveal that psychological resilience specifically shields against the neurotoxic effects of abuse by modulating networks involved in emotion regulation, salience, and sensorimotor processing. Targeted interventions should consider adversity dimensions and psychological resilience capacity to mitigate long-term mental health risks. En ligne : https://dx.doi.org/10.1017/S0954579426101564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Psychological resilience moderates the relationship between childhood adversity, brain network connectivity, and wellness [texte imprimé] / Yuanyuan LI, Auteur ; Zelin LIU, Auteur ; Bowen HU, Auteur ; Jiahua XU, Auteur ; Jiale XIAO, Auteur ; Boxuan CHEN, Auteur ; Ting TIAN, Auteur ; Ying HE, Auteur ; Shaozheng QIN, Auteur ; Danhua LIN, Auteur . - p.1774-1782. Langues : Anglais (eng) in Development and Psychopathology > 38-4 (October 2026) . - p.1774-1782 Mots-clés : brain network  childhood adversity  dimensional perspective  psychological resilience  resting-state functional connectivity Index. décimale : PER Périodiques Résumé : Childhood adversity impairs well-being, yet psychological resilience may buffer its impact. Using resting-state fMRI in 94 rural Chinese children (ages 10–14), we examined whether psychological resilience protects brain network connectivity from adversity and its relevance to psychological well-being. Psychological resilience significantly moderated the impact of abuse, but not neglect, on limbic connectivity. Low-resilience children exposed to abuse showed heightened limbic-somatomotor and limbic-ventral attention connectivity, which predicted greater somatization and depression at baseline and more severe levels of anxiety six months later. These associations were absent in high-resilience children. Our findings reveal that psychological resilience specifically shields against the neurotoxic effects of abuse by modulating networks involved in emotion regulation, salience, and sensorimotor processing. Targeted interventions should consider adversity dimensions and psychological resilience capacity to mitigate long-term mental health risks. En ligne : https://dx.doi.org/10.1017/S0954579426101564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

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