18 recherche sur le mot-clé 'childhood adversity'

Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors / N. M. FAVA in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Titre : Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors Type de document : Texte imprimé et/ou numérique Auteurs : N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur Article en page(s) : p.1439-1450 Langues : Anglais (eng) Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors [Texte imprimé et/ou numérique] / N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur . - p.1439-1450. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Childhood adversity is associated with reduced threat-safety discrimination and increased fear generalization in 12- to 16-year-olds / Aleksandra LECEI ; Maarten JACKERS ; Lise JENNEN ; Koen SCHRUERS ; Bram VERVLIET ; Bart BOETS ; Ruud VAN WINKEL in Journal of Child Psychology and Psychiatry, 66-6 (June 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.821-833 Titre : Childhood adversity is associated with reduced threat-safety discrimination and increased fear generalization in 12- to 16-year-olds Type de document : Texte imprimé et/ou numérique Auteurs : Aleksandra LECEI, Auteur ; Maarten JACKERS, Auteur ; Lise JENNEN, Auteur ; Koen SCHRUERS, Auteur ; Bram VERVLIET, Auteur ; Bart BOETS, Auteur ; Ruud VAN WINKEL, Auteur Article en page(s) : p.821-833 Langues : Anglais (eng) Mots-clés : Childhood adversity  fear conditioning  fear generalization  adolescence Index. décimale : PER Périodiques Résumé : Background Childhood adversity poses a major transdiagnostic risk for a host of psychiatric disorders. Altered threat-related information processing has been put forward as a potential process underlying the association between childhood adversity and psychiatric disorders, with previous research providing support for decreased discrimination between threat and safety cues, in both children and adults exposed to adversity. This altered threat-safety discrimination has been hypothesized to stem from increased generalization of fear, yet to date, this hypothesis has not been tested in youth. Methods Here, we investigate whether childhood adversity is associated with fear generalization during adolescence. 119 adolescents between 12 and 16?years of age (mean?=?13.95), of whom 63 exposed to childhood adversity, completed a fear generalization paradigm. Fear conditioning was assessed through trial-by-trial US expectancy ratings and post-experimental ratings of fear, valence and arousal. Additionally, we administered a perceptual discrimination task to assess the potential impact of perceptual discrimination abilities upon fear generalization. Results In line with our hypotheses, results showed that childhood adversity is associated with (1) reduced threat-safety differentiation during fear acquisition and (2) increased fear generalization in both boys and girls, albeit to a different extent, as boys showed more generalization towards safety cues while girls showed more generalization towards dangerous cues. Moreover, this overgeneralization of fear could not be attributed to group differences in perceptual discrimination. Conclusions Altered fear learning may be an important process through which adversity increases risk for the development of psychopathology. Longitudinal research is essential to elucidate risk and resilience patterns following childhood adversity. En ligne : https://doi.org/10.1111/jcpp.14092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Childhood adversity is associated with reduced threat-safety discrimination and increased fear generalization in 12- to 16-year-olds [Texte imprimé et/ou numérique] / Aleksandra LECEI, Auteur ; Maarten JACKERS, Auteur ; Lise JENNEN, Auteur ; Koen SCHRUERS, Auteur ; Bram VERVLIET, Auteur ; Bart BOETS, Auteur ; Ruud VAN WINKEL, Auteur . - p.821-833. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.821-833 Mots-clés : Childhood adversity  fear conditioning  fear generalization  adolescence Index. décimale : PER Périodiques Résumé : Background Childhood adversity poses a major transdiagnostic risk for a host of psychiatric disorders. Altered threat-related information processing has been put forward as a potential process underlying the association between childhood adversity and psychiatric disorders, with previous research providing support for decreased discrimination between threat and safety cues, in both children and adults exposed to adversity. This altered threat-safety discrimination has been hypothesized to stem from increased generalization of fear, yet to date, this hypothesis has not been tested in youth. Methods Here, we investigate whether childhood adversity is associated with fear generalization during adolescence. 119 adolescents between 12 and 16?years of age (mean?=?13.95), of whom 63 exposed to childhood adversity, completed a fear generalization paradigm. Fear conditioning was assessed through trial-by-trial US expectancy ratings and post-experimental ratings of fear, valence and arousal. Additionally, we administered a perceptual discrimination task to assess the potential impact of perceptual discrimination abilities upon fear generalization. Results In line with our hypotheses, results showed that childhood adversity is associated with (1) reduced threat-safety differentiation during fear acquisition and (2) increased fear generalization in both boys and girls, albeit to a different extent, as boys showed more generalization towards safety cues while girls showed more generalization towards dangerous cues. Moreover, this overgeneralization of fear could not be attributed to group differences in perceptual discrimination. Conclusions Altered fear learning may be an important process through which adversity increases risk for the development of psychopathology. Longitudinal research is essential to elucidate risk and resilience patterns following childhood adversity. En ligne : https://doi.org/10.1111/jcpp.14092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated / Steven R. H. BEACH in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.803-820 Titre : Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated Type de document : Texte imprimé et/ou numérique Auteurs : Steven R. H. BEACH, Auteur ; Mei Ling ONG, Auteur ; Man-Kit LEI, Auteur ; Eric KLOPACK, Auteur ; Sierra E. CARTER, Auteur ; Ronald L. SIMONS, Auteur ; Frederick X. GIBBONS, Auteur ; Justin A. LAVNER, Auteur ; Robert A. PHILIBERT, Auteur ; Kaixiong YE, Auteur Article en page(s) : p.803-820 Langues : Anglais (eng) Mots-clés : African American  childhood adversity  genetic risk  health disparities  obesity Index. décimale : PER Périodiques Résumé : Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year period, we examined change in body mass index (BMI) across adolescence as one possible mechanism linking childhood adversity and adult health. We found associations of childhood adversity with objective indicators of young adult health, including a cardiometabolic risk index, a methylomic aging index, and a count of chronic health conditions. Childhood adversities were associated with objective indicators indirectly through their association with gains in BMI across adolescence and early adulthood. We also found evidence of an association of genetic risk with weight gain across adolescence and young adult health, as well as genetic moderation of childhood adversity's effect on gains in BMI, resulting in moderated mediation. These patterns indicated that genetic risk moderated the indirect pathways from childhood adversity to young adult health outcomes and childhood adversity moderated the indirect pathways from genetic risk to young adult health outcomes through effects on weight gain during adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579420000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated [Texte imprimé et/ou numérique] / Steven R. H. BEACH, Auteur ; Mei Ling ONG, Auteur ; Man-Kit LEI, Auteur ; Eric KLOPACK, Auteur ; Sierra E. CARTER, Auteur ; Ronald L. SIMONS, Auteur ; Frederick X. GIBBONS, Auteur ; Justin A. LAVNER, Auteur ; Robert A. PHILIBERT, Auteur ; Kaixiong YE, Auteur . - p.803-820. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.803-820 Mots-clés : African American  childhood adversity  genetic risk  health disparities  obesity Index. décimale : PER Périodiques Résumé : Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year period, we examined change in body mass index (BMI) across adolescence as one possible mechanism linking childhood adversity and adult health. We found associations of childhood adversity with objective indicators of young adult health, including a cardiometabolic risk index, a methylomic aging index, and a count of chronic health conditions. Childhood adversities were associated with objective indicators indirectly through their association with gains in BMI across adolescence and early adulthood. We also found evidence of an association of genetic risk with weight gain across adolescence and young adult health, as well as genetic moderation of childhood adversity's effect on gains in BMI, resulting in moderated mediation. These patterns indicated that genetic risk moderated the indirect pathways from childhood adversity to young adult health outcomes and childhood adversity moderated the indirect pathways from genetic risk to young adult health outcomes through effects on weight gain during adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579420000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Meta-analysis of associations between childhood adversity and diurnal cortisol regulation / Laura PERRONE in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1323-1355 Titre : Meta-analysis of associations between childhood adversity and diurnal cortisol regulation Type de document : Texte imprimé et/ou numérique Auteurs : Laura PERRONE, Auteur ; Daneele THORPE, Auteur ; Grace SHARIAT PANAHI, Auteur ; Yukihiro KITAGAWA, Auteur ; Oliver LINDHIEM, Auteur ; Kristin BERNARD, Auteur Article en page(s) : p.1323-1355 Langues : Anglais (eng) Mots-clés : Childhood adversity  Cortisol  Hypothalamic-pituitary-adrenal axis  Meta-analysis Index. décimale : PER Périodiques Résumé : Childhood adversity has been associated with hypothalamic-pituitary-adrenal axis dysregulation, which is associated with mental and physical health consequences. However, associations between childhood adversity and cortisol regulation in the current literature vary in magnitude and direction. This multilevel meta-analysis examines the association between childhood adversity and diurnal cortisol measures, as well as potential moderators of these effects (adversity timing and type, study or sample characteristics). A search was conducted in online databases PsycINFO and PubMed for papers written in English. After screening for exclusion criteria (papers examining animals, pregnant women, people receiving hormonal treatment, people with endocrine disorders, cortisol before age 2 months, or cortisol after an intervention), 303 papers were identified for inclusion. In total, 441 effect sizes were extracted from 156 manuscripts representing 104 studies. A significant overall effect was found between childhood adversity and bedtime cortisol, r = 0.047, 95% CI [0.005, 0.089], t = 2.231, p = 0.028. All other overall and moderation effects were not significant. The lack of overall effects may reflect the importance of the timing and nature of childhood adversity to adversity?s impact on cortisol regulation. Thus, we offer concrete recommendations for testing theoretical models linking early adversity and stress physiology. En ligne : https://dx.doi.org/10.1017/S0954579423000561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Meta-analysis of associations between childhood adversity and diurnal cortisol regulation [Texte imprimé et/ou numérique] / Laura PERRONE, Auteur ; Daneele THORPE, Auteur ; Grace SHARIAT PANAHI, Auteur ; Yukihiro KITAGAWA, Auteur ; Oliver LINDHIEM, Auteur ; Kristin BERNARD, Auteur . - p.1323-1355. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1323-1355 Mots-clés : Childhood adversity  Cortisol  Hypothalamic-pituitary-adrenal axis  Meta-analysis Index. décimale : PER Périodiques Résumé : Childhood adversity has been associated with hypothalamic-pituitary-adrenal axis dysregulation, which is associated with mental and physical health consequences. However, associations between childhood adversity and cortisol regulation in the current literature vary in magnitude and direction. This multilevel meta-analysis examines the association between childhood adversity and diurnal cortisol measures, as well as potential moderators of these effects (adversity timing and type, study or sample characteristics). A search was conducted in online databases PsycINFO and PubMed for papers written in English. After screening for exclusion criteria (papers examining animals, pregnant women, people receiving hormonal treatment, people with endocrine disorders, cortisol before age 2 months, or cortisol after an intervention), 303 papers were identified for inclusion. In total, 441 effect sizes were extracted from 156 manuscripts representing 104 studies. A significant overall effect was found between childhood adversity and bedtime cortisol, r = 0.047, 95% CI [0.005, 0.089], t = 2.231, p = 0.028. All other overall and moderation effects were not significant. The lack of overall effects may reflect the importance of the timing and nature of childhood adversity to adversity?s impact on cortisol regulation. Thus, we offer concrete recommendations for testing theoretical models linking early adversity and stress physiology. En ligne : https://dx.doi.org/10.1017/S0954579423000561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity / Edward T. BULLMORE ; Raymond J. DOLAN ; Peter FONAGY ; Nadia GONZÁLEZ-GARCÍA ; Ian GOODYER ; Peter B. JONES ; Sol LIM ; Laura MORENO-LÓPEZ ; Rafael ROMERO-GARCIA ; Samantha N. SALLIE ; Maximilian SCHEUPLEIN ; Franti?ek VÁ?A ; Kirstie J. WHITAKER ; Anne-Laura VAN HARMELEN in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2253-2263 Titre : Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity Type de document : Texte imprimé et/ou numérique Auteurs : Edward T. BULLMORE, Auteur ; Raymond J. DOLAN, Auteur ; Peter FONAGY, Auteur ; Nadia GONZÁLEZ-GARCÍA, Auteur ; Ian GOODYER, Auteur ; Peter B. JONES, Auteur ; Sol LIM, Auteur ; Laura MORENO-LÓPEZ, Auteur ; Rafael ROMERO-GARCIA, Auteur ; Samantha N. SALLIE, Auteur ; Maximilian SCHEUPLEIN, Auteur ; Franti?ek VÁ?A, Auteur ; Kirstie J. WHITAKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur Article en page(s) : p.2253-2263 Mots-clés : adolescence  brain networks  childhood adversity  resilience  structural covariance Index. décimale : PER Périodiques Résumé : Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14?24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning. En ligne : https://dx.doi.org/10.1017/S0954579423000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Resilient functioning is associated with altered structural brain network topology in adolescents exposed to childhood adversity [Texte imprimé et/ou numérique] / Edward T. BULLMORE, Auteur ; Raymond J. DOLAN, Auteur ; Peter FONAGY, Auteur ; Nadia GONZÁLEZ-GARCÍA, Auteur ; Ian GOODYER, Auteur ; Peter B. JONES, Auteur ; Sol LIM, Auteur ; Laura MORENO-LÓPEZ, Auteur ; Rafael ROMERO-GARCIA, Auteur ; Samantha N. SALLIE, Auteur ; Maximilian SCHEUPLEIN, Auteur ; Franti?ek VÁ?A, Auteur ; Kirstie J. WHITAKER, Auteur ; Anne-Laura VAN HARMELEN, Auteur . - p.2253-2263. in Development and Psychopathology > 35-5 (December 2023) . - p.2253-2263 Mots-clés : adolescence  brain networks  childhood adversity  resilience  structural covariance Index. décimale : PER Périodiques Résumé : Childhood adversity is one of the strongest predictors of adolescent mental illness. Therefore, it is critical that the mechanisms that aid resilient functioning in individuals exposed to childhood adversity are better understood. Here, we examined whether resilient functioning was related to structural brain network topology. We quantified resilient functioning at the individual level as psychosocial functioning adjusted for the severity of childhood adversity in a large sample of adolescents (N = 2406, aged 14?24). Next, we examined nodal degree (the number of connections that brain regions have in a network) using brain-wide cortical thickness measures in a representative subset (N = 275) using a sliding window approach. We found that higher resilient functioning was associated with lower nodal degree of multiple regions including the dorsolateral prefrontal cortex, the medial prefrontal cortex, and the posterior superior temporal sulcus (z > 1.645). During adolescence, decreases in nodal degree are thought to reflect a normative developmental process that is part of the extensive remodeling of structural brain network topology. Prior findings in this sample showed that decreased nodal degree was associated with age, as such our findings of negative associations between nodal degree and resilient functioning may therefore potentially resemble a more mature structural network configuration in individuals with higher resilient functioning. En ligne : https://dx.doi.org/10.1017/S0954579423000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Stress perception following childhood adversity: Unique associations with adversity type and sex / Allison M. LOPILATO in Development and Psychopathology, 32-1 (February 2020)  

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Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores / Lisa R. STARR in Development and Psychopathology, 33-4 (October 2021)  

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Direct and indirect associations between childhood adversity and emotional and behavioral problems at age 14: A network analytical approach / Tjeerd Rudmer DE VRIES in Development and Psychopathology, 36-3 (August 2024)  

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Identifying intervention strategies for preventing the mental health consequences of childhood adversity: A modified Delphi study / Leslie R. RITH-NAJARIAN in Development and Psychopathology, 33-2 (May 2021)  

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Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation / Meghan HUANG in Development and Psychopathology, 32-3 (August 2020)  

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