Impaired sensory–motor integration in children with attention-deficit/hyperactivity disorder during visual search / Dongwei LI in Journal of Child Psychology and Psychiatry, 67-1 (January 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.17-26 Titre : Impaired sensory–motor integration in children with attention-deficit/hyperactivity disorder during visual search Type de document : texte imprimé Auteurs : Dongwei LI, Auteur ; Xiangsheng LUO, Auteur ; Chen DANG, Auteur ; Yuanjun KONG, Auteur ; Yiwen LI, Auteur ; Yu ZHU, Auteur ; Jing HUANG, Auteur ; Yufeng WANG, Auteur ; Jialiang GUO, Auteur ; Li SUN, Auteur ; Yan SONG, Auteur Article en page(s) : p.17-26 Langues : Anglais (eng) Mots-clés : ADHD  visuomotor coordination  EEG  attentional selection  sensorimotor timing Index. décimale : PER Périodiques Résumé : Objective Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-age children. Abnormal sensory?motor integration, such as concurrent visuomotor selection, is a prominent feature of ADHD. However, underlying pathophysiological substrates of impaired sensory?motor integration in childhood ADHD remain unclear. Identifying neural markers of cognitive impairment in children with ADHD is vital for the early assisted diagnosis and the selection of intervention targets. Methods We collected electroencephalography (EEG) signals from 70 children with ADHD and 65 matched typically developing (TD) children while performing a visual search task. Oscillation-based multivariate pattern decoding was used to investigate visuomotor coordination during spatial attention. Results Compared with TD children, children with ADHD showed impairments in accuracy, response time, and response time variability. Multivariate machine learning revealed that the ADHD group showed deficits in alpha (visual-related) and beta (motor-related) power-based decoding accuracy, indicating the impaired sensory orienting and motor preparation. Importantly, children with ADHD exhibited a delay between alpha and beta decoding, suggesting a deficit of concurrent visuomotor coordination. However, this visuomotor asynchrony was absent in TD children. Furthermore, the degree of visuomotor asynchrony between alpha and beta decoding was predictive of behavioral impairments and symptom severity in children with ADHD. Conclusions These observations reveal that impaired concurrent visuomotor coordination might be a potential neural marker of impaired sensory?motor integration in children with ADHD, further advancing the understanding of cognitive deficits, and providing potential research directions for the early diagnosis and optimization of intervention in neurodevelopmental disorders. En ligne : https://doi.org/10.1111/jcpp.70004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577 [article] Impaired sensory–motor integration in children with attention-deficit/hyperactivity disorder during visual search [texte imprimé] / Dongwei LI, Auteur ; Xiangsheng LUO, Auteur ; Chen DANG, Auteur ; Yuanjun KONG, Auteur ; Yiwen LI, Auteur ; Yu ZHU, Auteur ; Jing HUANG, Auteur ; Yufeng WANG, Auteur ; Jialiang GUO, Auteur ; Li SUN, Auteur ; Yan SONG, Auteur . - p.17-26. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.17-26 Mots-clés : ADHD  visuomotor coordination  EEG  attentional selection  sensorimotor timing Index. décimale : PER Périodiques Résumé : Objective Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-age children. Abnormal sensory?motor integration, such as concurrent visuomotor selection, is a prominent feature of ADHD. However, underlying pathophysiological substrates of impaired sensory?motor integration in childhood ADHD remain unclear. Identifying neural markers of cognitive impairment in children with ADHD is vital for the early assisted diagnosis and the selection of intervention targets. Methods We collected electroencephalography (EEG) signals from 70 children with ADHD and 65 matched typically developing (TD) children while performing a visual search task. Oscillation-based multivariate pattern decoding was used to investigate visuomotor coordination during spatial attention. Results Compared with TD children, children with ADHD showed impairments in accuracy, response time, and response time variability. Multivariate machine learning revealed that the ADHD group showed deficits in alpha (visual-related) and beta (motor-related) power-based decoding accuracy, indicating the impaired sensory orienting and motor preparation. Importantly, children with ADHD exhibited a delay between alpha and beta decoding, suggesting a deficit of concurrent visuomotor coordination. However, this visuomotor asynchrony was absent in TD children. Furthermore, the degree of visuomotor asynchrony between alpha and beta decoding was predictive of behavioral impairments and symptom severity in children with ADHD. Conclusions These observations reveal that impaired concurrent visuomotor coordination might be a potential neural marker of impaired sensory?motor integration in children with ADHD, further advancing the understanding of cognitive deficits, and providing potential research directions for the early diagnosis and optimization of intervention in neurodevelopmental disorders. En ligne : https://doi.org/10.1111/jcpp.70004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577

The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder / Lu LIU in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.58-66 Titre : The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder Type de document : texte imprimé Auteurs : Lu LIU, Auteur ; Jia CHENG, Auteur ; Haimei LI, Auteur ; Li YANG, Auteur ; Qiujin QIAN, Auteur ; Yufeng WANG, Auteur Article en page(s) : p.58-66 Langues : Anglais (eng) Mots-clés : ADHD  ODD  NET1  association Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) often coexist and shared some genetic influences. Evidence from the existing literature indicated that comorbid with ODD may increase the heterogeneity of ADHD genetics. Our present study sought to investigate the role of norepinephrine transporter gene (NET1) for ADHD comorbid with ODD. Methods Six single nucleotide polymorphisms (SNPs) of NET1 were genotyped for a total of 1,815 ADHD cases, including 587 subjects (32.3%) with ODD. Chi-square tests were conducted for pseudo case–control study comparing allelic and genotypic distributions between ADHD with and without ODD. Among them, there were 1,249 probands together with their parents composing trios for family-based association studies using transmission disequilibrium tests (TDTs). In addition, 1,337 ADHD probands have detailed information of ODD symptoms and were included for quantitative analyses with genotypes using analyses of covariance (ANCOVA). To consider the overlap and correlation of other comorbidities with ODD and eliminate their potential confounding effect, we further repeated above analyses for ‘pure ADHD+ODD’ versus ‘ADHD-only’ after excluding other comorbidities except for ODD. Results The pseudo case–control study showed different allelic and genotypic distributions of SNP rs3785143 between ADHD with ODD and those without ODD. Family-based association tests indicated overtransmission of the T allele of rs3785143 in ADHD with ODD trios, but no biased transmission in those without ODD. ANCOVA showed association between genotypes of rs3785143 with ODD symptoms in ADHD probands, especially with ‘Argumentative/Defiant Behavior (ADB)’ dimension after controlling gender, age, clinical subtypes and intelligence. Above association still existed after removing the samples with other comorbidities. Conclusion NET1 was associated with comorbidity of ODD and ODD symptoms in ADHD probands. Our findings emphasize the importance of considering the comorbidity of ODD in ADHD genetic studies, especially ADHD with ADB. However, further replication in independent sample or different populations is still needed. En ligne : http://dx.doi.org/10.1111/jcpp.12278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder [texte imprimé] / Lu LIU, Auteur ; Jia CHENG, Auteur ; Haimei LI, Auteur ; Li YANG, Auteur ; Qiujin QIAN, Auteur ; Yufeng WANG, Auteur . - p.58-66. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.58-66 Mots-clés : ADHD  ODD  NET1  association Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) often coexist and shared some genetic influences. Evidence from the existing literature indicated that comorbid with ODD may increase the heterogeneity of ADHD genetics. Our present study sought to investigate the role of norepinephrine transporter gene (NET1) for ADHD comorbid with ODD. Methods Six single nucleotide polymorphisms (SNPs) of NET1 were genotyped for a total of 1,815 ADHD cases, including 587 subjects (32.3%) with ODD. Chi-square tests were conducted for pseudo case–control study comparing allelic and genotypic distributions between ADHD with and without ODD. Among them, there were 1,249 probands together with their parents composing trios for family-based association studies using transmission disequilibrium tests (TDTs). In addition, 1,337 ADHD probands have detailed information of ODD symptoms and were included for quantitative analyses with genotypes using analyses of covariance (ANCOVA). To consider the overlap and correlation of other comorbidities with ODD and eliminate their potential confounding effect, we further repeated above analyses for ‘pure ADHD+ODD’ versus ‘ADHD-only’ after excluding other comorbidities except for ODD. Results The pseudo case–control study showed different allelic and genotypic distributions of SNP rs3785143 between ADHD with ODD and those without ODD. Family-based association tests indicated overtransmission of the T allele of rs3785143 in ADHD with ODD trios, but no biased transmission in those without ODD. ANCOVA showed association between genotypes of rs3785143 with ODD symptoms in ADHD probands, especially with ‘Argumentative/Defiant Behavior (ADB)’ dimension after controlling gender, age, clinical subtypes and intelligence. Above association still existed after removing the samples with other comorbidities. Conclusion NET1 was associated with comorbidity of ODD and ODD symptoms in ADHD probands. Our findings emphasize the importance of considering the comorbidity of ODD in ADHD genetic studies, especially ADHD with ADB. However, further replication in independent sample or different populations is still needed. En ligne : http://dx.doi.org/10.1111/jcpp.12278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

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