Birth gap and the recurrence risk of autism spectrum disorders: A population-based cohort study / Michael BEENSTOCK in Research in Autism Spectrum Disorders, 17 (September 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 17 (September 2015) . - p.86-94 Titre : Birth gap and the recurrence risk of autism spectrum disorders: A population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Michael BEENSTOCK, Auteur ; Raanan RAZ, Auteur ; Hagai LEVINE, Auteur Année de publication : 2015 Article en page(s) : p.86-94 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder recurrence risk  Birth gap  Birth spacing  Birth order  Risk  Epidemiology Index. décimale : PER Périodiques Résumé : Abstract Population-based data on the magnitude and determinants of Autism Spectrum Disorder (ASD) recurrence risk in families with an index case are rare. We examined whether short birth gaps and other birth spacing factors increase the risk of recurrence, using a population-based cohort study in Israel. We examined records of younger siblings of index cases (children diagnosed with ASD), and estimated recurrence risk and its determinants. Overall, 5.25% (261/4976) of younger siblings were diagnosed with ASD. Younger siblings with birth gaps less than two years of their index case had significantly higher risk compared to the rest (odds ratio = 1.66, 95% CI 1.25–2.22). The association remained significant in models adjusted for sex of the index cases and their younger siblings, ethnicity, parental ages and birth order (odds ratio = 1.43, CI 1.03–1.96). This finding suggests that short birth gaps from the index case increase the risk of ASD among younger siblings. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Birth gap and the recurrence risk of autism spectrum disorders: A population-based cohort study [Texte imprimé et/ou numérique] / Michael BEENSTOCK, Auteur ; Raanan RAZ, Auteur ; Hagai LEVINE, Auteur . - 2015 . - p.86-94. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 17 (September 2015) . - p.86-94 Mots-clés : Autism spectrum disorder recurrence risk  Birth gap  Birth spacing  Birth order  Risk  Epidemiology Index. décimale : PER Périodiques Résumé : Abstract Population-based data on the magnitude and determinants of Autism Spectrum Disorder (ASD) recurrence risk in families with an index case are rare. We examined whether short birth gaps and other birth spacing factors increase the risk of recurrence, using a population-based cohort study in Israel. We examined records of younger siblings of index cases (children diagnosed with ASD), and estimated recurrence risk and its determinants. Overall, 5.25% (261/4976) of younger siblings were diagnosed with ASD. Younger siblings with birth gaps less than two years of their index case had significantly higher risk compared to the rest (odds ratio = 1.66, 95% CI 1.25–2.22). The association remained significant in models adjusted for sex of the index cases and their younger siblings, ethnicity, parental ages and birth order (odds ratio = 1.43, CI 1.03–1.96). This finding suggests that short birth gaps from the index case increase the risk of ASD among younger siblings. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.06.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Selection bias induced by reproductive stoppage in estimates of recurrence risk for autism spectrum disorders / Michael BEENSTOCK in Research in Autism Spectrum Disorders, 89 (November 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 89 (November 2021) . - 101863 Titre : Selection bias induced by reproductive stoppage in estimates of recurrence risk for autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Michael BEENSTOCK, Auteur Article en page(s) : 101863 Langues : Anglais (eng) Mots-clés : Recurrence risk of ASD  Reproductive stoppage  Selection bias  Incidental truncation method  Inverse probability weighting Index. décimale : PER Périodiques Résumé : Background In observational studies it is implicitly assumed that the data are representative of the general population. Self-selection by individuals may undermine this assumption, inducing sample selection bias. In studies of recurrence risk of autism spectrum disorder (ASD) it is implicitly assumed that parents who had no further children face the same recurrence risk as parents who had further children. If this assumption is false, estimates of recurrence risk may be too high or too low. Method Two canonical statistical methods for detecting and correcting for sample selection bias, including incidental truncation and inverse probability weighting, are applied to population cohort data for Israel. The data comprise 8205 younger siblings of 9117 children diagnosed with ASD, among which there were 371 recurrences. Reproductive stoppage occurred in 4216 out of 9117 families. Participants are distinguished by demographics (gender, age), ethnicity (Jews and Arabs), religiosity, birth cohort and socioeconomic status. Results Correcting for selection bias using the incidental truncation method, the average risk of recurrence is 3.83 (95 %CI: 3.41 %–4.24 %) instead of 4.53 % (95 %CI: 4.08 %–4.98 %). The bias has p-value 0.082. Since the incidental truncation method may be sensitive to parametric assumptions regarding the joint distribution of unobserved heterogeneity in stoppage and recurrence risk, robustness tests are carried out using alternative parametric assumptions, including copulas. Results using the method of inverse probability weighting were unsatisfactory because they were sensitive to hidden confounders. Conclusions Studies of recurrent risk of ASD should take account of potential selection bias induced by reproductive stoppage. En ligne : https://doi.org/10.1016/j.rasd.2021.101863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Selection bias induced by reproductive stoppage in estimates of recurrence risk for autism spectrum disorders [Texte imprimé et/ou numérique] / Michael BEENSTOCK, Auteur . - 101863. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 89 (November 2021) . - 101863 Mots-clés : Recurrence risk of ASD  Reproductive stoppage  Selection bias  Incidental truncation method  Inverse probability weighting Index. décimale : PER Périodiques Résumé : Background In observational studies it is implicitly assumed that the data are representative of the general population. Self-selection by individuals may undermine this assumption, inducing sample selection bias. In studies of recurrence risk of autism spectrum disorder (ASD) it is implicitly assumed that parents who had no further children face the same recurrence risk as parents who had further children. If this assumption is false, estimates of recurrence risk may be too high or too low. Method Two canonical statistical methods for detecting and correcting for sample selection bias, including incidental truncation and inverse probability weighting, are applied to population cohort data for Israel. The data comprise 8205 younger siblings of 9117 children diagnosed with ASD, among which there were 371 recurrences. Reproductive stoppage occurred in 4216 out of 9117 families. Participants are distinguished by demographics (gender, age), ethnicity (Jews and Arabs), religiosity, birth cohort and socioeconomic status. Results Correcting for selection bias using the incidental truncation method, the average risk of recurrence is 3.83 (95 %CI: 3.41 %–4.24 %) instead of 4.53 % (95 %CI: 4.08 %–4.98 %). The bias has p-value 0.082. Since the incidental truncation method may be sensitive to parametric assumptions regarding the joint distribution of unobserved heterogeneity in stoppage and recurrence risk, robustness tests are carried out using alternative parametric assumptions, including copulas. Results using the method of inverse probability weighting were unsatisfactory because they were sensitive to hidden confounders. Conclusions Studies of recurrent risk of ASD should take account of potential selection bias induced by reproductive stoppage. En ligne : https://doi.org/10.1016/j.rasd.2021.101863 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

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