[article] 
inAutism Research > 10-9 (September 2017) . - p.1470-1480

Titre :	The joint effect of air pollution exposure and copy number variation on risk for autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Dokyoon KIM, Auteur ; Heather E. VOLK, Auteur ; Santhosh GIRIRAJAN, Auteur ; Sarah PENDERGRASS, Auteur ; Molly A. HALL, Auteur ; Shefali S. VERMA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robin L. HANSEN, Auteur ; Debashis GHOSH, Auteur ; Yunin LUDENA-RODRIGUEZ, Auteur ; Kyoungmi KIM, Auteur ; Marylyn D. RITCHIE, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Scott B. SELLECK, Auteur
Article en page(s) :	p.1470-1480
Langues :	Anglais (eng)
Mots-clés :	autism  copy number variation  air pollution  gene-environment interaction
Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation, exposure to air pollutants, and the interaction between the two on autism risk, were evaluated in the population-based case-control Childhood Autism Risks from Genetics and Environment (CHARGE) Study. For the current investigation, we included only those CHARGE children (a) who met criteria for autism or typical development and (b) for whom our team had conducted both genetic evaluation of copy number burden and determination of environmental air pollution exposures based on mapping addresses from the pregnancy and early childhood. This sample consisted of 158 cases of children with autism and 147 controls with typical development. Multiple logistic regression models were fit with and without environmental variable-copy number burden interactions. We found no correlation between average air pollution exposure from conception to age 2 years and the child's CNV burden. We found a significant interaction in which a 1SD increase in duplication burden combined with a 1SD increase in ozone exposure was associated with an elevated autism risk (OR 3.4, P?
En ligne :	http://dx.doi.org/10.1002/aur.1799
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320

[article] The joint effect of air pollution exposure and copy number variation on risk for autism [Texte imprimé et/ou numérique] / Dokyoon KIM, Auteur ; Heather E. VOLK, Auteur ; Santhosh GIRIRAJAN, Auteur ; Sarah PENDERGRASS, Auteur ; Molly A. HALL, Auteur ; Shefali S. VERMA, Auteur ; Rebecca J. SCHMIDT, Auteur ; Robin L. HANSEN, Auteur ; Debashis GHOSH, Auteur ; Yunin LUDENA-RODRIGUEZ, Auteur ; Kyoungmi KIM, Auteur ; Marylyn D. RITCHIE, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Scott B. SELLECK, Auteur . - p.1470-1480.
Langues : Anglais (eng)
in Autism Research > 10-9 (September 2017) . - p.1470-1480

Mots-clés :	autism  copy number variation  air pollution  gene-environment interaction
Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation, exposure to air pollutants, and the interaction between the two on autism risk, were evaluated in the population-based case-control Childhood Autism Risks from Genetics and Environment (CHARGE) Study. For the current investigation, we included only those CHARGE children (a) who met criteria for autism or typical development and (b) for whom our team had conducted both genetic evaluation of copy number burden and determination of environmental air pollution exposures based on mapping addresses from the pregnancy and early childhood. This sample consisted of 158 cases of children with autism and 147 controls with typical development. Multiple logistic regression models were fit with and without environmental variable-copy number burden interactions. We found no correlation between average air pollution exposure from conception to age 2 years and the child's CNV burden. We found a significant interaction in which a 1SD increase in duplication burden combined with a 1SD increase in ozone exposure was associated with an elevated autism risk (OR 3.4, P?
En ligne :	http://dx.doi.org/10.1002/aur.1799
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320