[article]
Titre : |
Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Jacob ELLEGOOD, Auteur ; Nobuhiro NAKAI, Auteur ; Jin NAKATANI, Auteur ; Mark HENKELMAN, Auteur ; Toru TAKUMI, Auteur ; Jason LERCH, Auteur |
Article en page(s) : |
p.545-555 |
Langues : |
Anglais (eng) |
Mots-clés : |
animal models structural MRI neuroanatomy copy number variation molecular genetics 15q11-13 duplication |
Index. décimale : |
PER Périodiques |
Résumé : |
Paternally and maternally inherited deletions and duplications of human chromosome 15q11-13 are relatively common in the human population. Furthermore, duplications in the 15q region are often associated with autism. Both maternal and paternal interstitial 15q11-13 duplication mouse models have been previously created, where several behavioral differences were found in the paternal duplication (patDp/+) mouse but not in the maternal duplication (matDp/+). These included decreased sociability, behavioral inflexibility, abnormal ultrasonic vocalizations, decreased spontaneous activity, and increased anxiety. Similarly, in the current study, we found several anatomical differences in the patDp/+ mice that were not seen in the matDp/+ mice. Regional differences that are evident only in the paternal duplication are a smaller dentate gyrus and smaller medial striatum. These differences may be responsible for the behavioral inflexibility. Furthermore, a smaller dorsal raphe nucleus could be responsible for the reported serotonin defects. This study highlights consistency that can be found between behavioral and anatomical phenotyping. Autism Res 2015, 8: 545–555. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. |
En ligne : |
http://dx.doi.org/10.1002/aur.1469 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 |
in Autism Research > 8-5 (October 2015) . - p.545-555
[article] Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model [Texte imprimé et/ou numérique] / Jacob ELLEGOOD, Auteur ; Nobuhiro NAKAI, Auteur ; Jin NAKATANI, Auteur ; Mark HENKELMAN, Auteur ; Toru TAKUMI, Auteur ; Jason LERCH, Auteur . - p.545-555. Langues : Anglais ( eng) in Autism Research > 8-5 (October 2015) . - p.545-555
Mots-clés : |
animal models structural MRI neuroanatomy copy number variation molecular genetics 15q11-13 duplication |
Index. décimale : |
PER Périodiques |
Résumé : |
Paternally and maternally inherited deletions and duplications of human chromosome 15q11-13 are relatively common in the human population. Furthermore, duplications in the 15q region are often associated with autism. Both maternal and paternal interstitial 15q11-13 duplication mouse models have been previously created, where several behavioral differences were found in the paternal duplication (patDp/+) mouse but not in the maternal duplication (matDp/+). These included decreased sociability, behavioral inflexibility, abnormal ultrasonic vocalizations, decreased spontaneous activity, and increased anxiety. Similarly, in the current study, we found several anatomical differences in the patDp/+ mice that were not seen in the matDp/+ mice. Regional differences that are evident only in the paternal duplication are a smaller dentate gyrus and smaller medial striatum. These differences may be responsible for the behavioral inflexibility. Furthermore, a smaller dorsal raphe nucleus could be responsible for the reported serotonin defects. This study highlights consistency that can be found between behavioral and anatomical phenotyping. Autism Res 2015, 8: 545–555. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. |
En ligne : |
http://dx.doi.org/10.1002/aur.1469 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 |
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