Dépouillements

Autism screening and diagnosis in low resource settings: Challenges and opportunities to enhance research and services worldwide / Maureen S. DURKIN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.473-476 Titre : Autism screening and diagnosis in low resource settings: Challenges and opportunities to enhance research and services worldwide Type de document : Texte imprimé et/ou numérique Auteurs : Maureen S. DURKIN, Auteur ; Mayada ELSABBAGH, Auteur ; Josephine BARBARO, Auteur ; Melissa GLADSTONE, Auteur ; Francesca HAPPE, Auteur ; Rosa A. HOEKSTRA, Auteur ; Li-Ching LEE, Auteur ; Alexia RATTAZZI, Auteur ; Jennifer STAPEL-WAX, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Audrey THURM, Auteur ; Mark TOMLINSON, Auteur ; Andy SHIH, Auteur Article en page(s) : p.473-476 Langues : Anglais (eng) Mots-clés : diagnosis  early detection  epidemiology  intervention Index. décimale : PER Périodiques Résumé : Most research into the epidemiology, etiology, clinical manifestations, diagnosis and treatment of autism is based on studies in high income countries. Moreover, within high income countries, individuals of high socioeconomic status are disproportionately represented among participants in autism research. Corresponding disparities in access to autism screening, diagnosis, and treatment exist globally. One of the barriers perpetuating this imbalance is the high cost of proprietary tools for diagnosing autism and for delivering evidence-based therapies. Another barrier is the high cost of training of professionals and para-professionals to use the tools. Open-source and open access models provide a way to facilitate global collaboration and training. Using these models and technologies, the autism scientific community and clinicians worldwide should be able to work more effectively and efficiently than they have to date to address the global imbalance in autism knowledge and at the same time advance our understanding of autism and our ability to deliver cost-effective services to everyone in need. Autism Res 2015, 8: 473–476. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 [article] Autism screening and diagnosis in low resource settings: Challenges and opportunities to enhance research and services worldwide [Texte imprimé et/ou numérique] / Maureen S. DURKIN, Auteur ; Mayada ELSABBAGH, Auteur ; Josephine BARBARO, Auteur ; Melissa GLADSTONE, Auteur ; Francesca HAPPE, Auteur ; Rosa A. HOEKSTRA, Auteur ; Li-Ching LEE, Auteur ; Alexia RATTAZZI, Auteur ; Jennifer STAPEL-WAX, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Audrey THURM, Auteur ; Mark TOMLINSON, Auteur ; Andy SHIH, Auteur . - p.473-476. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.473-476 Mots-clés : diagnosis  early detection  epidemiology  intervention Index. décimale : PER Périodiques Résumé : Most research into the epidemiology, etiology, clinical manifestations, diagnosis and treatment of autism is based on studies in high income countries. Moreover, within high income countries, individuals of high socioeconomic status are disproportionately represented among participants in autism research. Corresponding disparities in access to autism screening, diagnosis, and treatment exist globally. One of the barriers perpetuating this imbalance is the high cost of proprietary tools for diagnosing autism and for delivering evidence-based therapies. Another barrier is the high cost of training of professionals and para-professionals to use the tools. Open-source and open access models provide a way to facilitate global collaboration and training. Using these models and technologies, the autism scientific community and clinicians worldwide should be able to work more effectively and efficiently than they have to date to address the global imbalance in autism knowledge and at the same time advance our understanding of autism and our ability to deliver cost-effective services to everyone in need. Autism Res 2015, 8: 473–476. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269

Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? / Tim CADMAN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.477-485 Titre : Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? Type de document : Texte imprimé et/ou numérique Auteurs : Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur Article en page(s) : p.477-485 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Obsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? [Texte imprimé et/ou numérique] / Tim CADMAN, Auteur ; Debbie SPAIN, Auteur ; Patrick JOHNSTON, Auteur ; Ailsa RUSSELL, Auteur ; David MATAIX-COLS, Auteur ; Michael C. CRAIG, Auteur ; Quinton DEELEY, Auteur ; Dene ROBERTSON, Auteur ; Clodagh M. MURPHY, Auteur ; Nicola GILLAN, Auteur ; C. Ellie WILSON, Auteur ; Maria MENDEZ, Auteur ; Christine ECKER, Auteur ; Eileen DALY, Auteur ; James FINDON, Auteur ; Karen GLASER, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Francesca HAPPE, Auteur ; Declan MURPHY, Auteur . - p.477-485. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.477-485 Mots-clés : autism spectrum disorder  adults  obsessive compulsive disorder  obsessive-compulsive inventory-revised  hoarding  self-report questionnaire Index. décimale : PER Périodiques Résumé : Little is known about the symptom profile of obsessive-compulsive disorder (OCD) in individuals who have autism spectrum disorders (ASD). It is also unknown whether self-report questionnaires are useful in measuring OCD in ASD. We sought to describe the symptom profiles of adults with ASD, OCD, and ASD?+?OCD using the Obsessive Compulsive Inventory-Revised (OCI-R), and to assess the utility of the OCI-R as a screening measure in a high-functioning adult ASD sample. Individuals with ASD (n?=?171), OCD (n?=?108), ASD?+?OCD (n?=?54) and control participants (n?=?92) completed the OCI-R. Individuals with ASD?+?OCD reported significantly higher levels of obsessive-compulsive symptoms than those with ASD alone. OCD symptoms were not significantly correlated with core ASD repetitive behaviors as measured on the ADI-R or ADOS-G. The OCI-R showed good psychometric properties and corresponded well with clinician diagnosis of OCD. Receiver operating characteristic analysis suggested cut-offs for OCI-R Total and Checking scores that discriminated well between ASD?+?versus –OCD, and fairly well between ASD-alone and OCD-alone. OCD manifests separately from ASD and is characterized by a different profile of repetitive thoughts and behaviors. The OCI-R appears to be useful as a screening tool in the ASD adult population. Autism Res 2015, 8: 477–485. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Social-Emotional Correlates of Early Stage Social Information Processing Skills in Children With and Without Autism Spectrum Disorder / Nicole M. RUSSO-PONSARAN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.486-496 Titre : Social-Emotional Correlates of Early Stage Social Information Processing Skills in Children With and Without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicole M. RUSSO-PONSARAN, Auteur ; Clark MCKOWN, Auteur ; Jason K. JOHNSON, Auteur ; Adelaide W. ALLEN, Auteur ; Bernadette EVANS-SMITH, Auteur ; Louis FOGG, Auteur Article en page(s) : p.486-496 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  social information processing  children  emotion recognition  theory of mind  pragmatic language Index. décimale : PER Périodiques Résumé : Difficulty processing social information is a defining feature of autism spectrum disorder (ASD). Yet the failure of children with ASD to process social information effectively is poorly understood. Using Crick and Dodge's model of social information processing (SIP), this study examined the relationship between social-emotional (SE) skills of pragmatic language, theory of mind, and emotion recognition on the one hand, and early stage SIP skills of problem identification and goal generation on the other. The study included a sample of school-aged children with and without ASD. SIP was assessed using hypothetical social situations in the context of a semistructured scenario-based interview. Pragmatic language, theory of mind, and emotion recognition were measured using direct assessments. Social thinking differences between children with and without ASD are largely differences of quantity (overall lower performance in ASD), not discrepancies in cognitive processing patterns. These data support theoretical models of the relationship between SE skills and SIP. Findings have implications for understanding the mechanisms giving rise to SIP deficits in ASD and may ultimately inform treatment development for children with ASD. Autism Res 2015, 8: 486–496. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Social-Emotional Correlates of Early Stage Social Information Processing Skills in Children With and Without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nicole M. RUSSO-PONSARAN, Auteur ; Clark MCKOWN, Auteur ; Jason K. JOHNSON, Auteur ; Adelaide W. ALLEN, Auteur ; Bernadette EVANS-SMITH, Auteur ; Louis FOGG, Auteur . - p.486-496. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.486-496 Mots-clés : autism spectrum disorder  social information processing  children  emotion recognition  theory of mind  pragmatic language Index. décimale : PER Périodiques Résumé : Difficulty processing social information is a defining feature of autism spectrum disorder (ASD). Yet the failure of children with ASD to process social information effectively is poorly understood. Using Crick and Dodge's model of social information processing (SIP), this study examined the relationship between social-emotional (SE) skills of pragmatic language, theory of mind, and emotion recognition on the one hand, and early stage SIP skills of problem identification and goal generation on the other. The study included a sample of school-aged children with and without ASD. SIP was assessed using hypothetical social situations in the context of a semistructured scenario-based interview. Pragmatic language, theory of mind, and emotion recognition were measured using direct assessments. Social thinking differences between children with and without ASD are largely differences of quantity (overall lower performance in ASD), not discrepancies in cognitive processing patterns. These data support theoretical models of the relationship between SE skills and SIP. Findings have implications for understanding the mechanisms giving rise to SIP deficits in ASD and may ultimately inform treatment development for children with ASD. Autism Res 2015, 8: 486–496. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Atypical Face Perception in Autism: A Point of View? / Karine MORIN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.497-506 Titre : Atypical Face Perception in Autism: A Point of View? Type de document : Texte imprimé et/ou numérique Auteurs : Karine MORIN, Auteur ; Jacalyn GUY, Auteur ; Claudine HABAK, Auteur ; Hugh R. WILSON, Auteur ; Linda PAGANI, Auteur ; Laurent MOTTRON, Auteur ; Armando BERTONE, Auteur Article en page(s) : p.497-506 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  face perception  local  global  synthetic faces  viewpoint change Index. décimale : PER Périodiques Résumé : Face perception is the most commonly used visual metric of social perception in autism. However, when found to be atypical, the origin of face perception differences in autism is contentious. One hypothesis proposes that a locally oriented visual analysis, characteristic of individuals with autism, ultimately affects performance on face tasks where a global analysis is optimal. The objective of this study was to evaluate this hypothesis by assessing face identity discrimination with synthetic faces presented with and without changes in viewpoint, with the former condition minimizing access to local face attributes used for identity discrimination. Twenty-eight individuals with autism and 30 neurotypical participants performed a face identity discrimination task. Stimuli were synthetic faces extracted from traditional face photographs in both front and 20° side viewpoints, digitized from 37 points to provide a continuous measure of facial geometry. Face identity discrimination thresholds were obtained using a two-alternative, temporal forced choice match-to-sample paradigm. Analyses revealed an interaction between group and condition, with group differences found only for the viewpoint change condition, where performance in the autism group was decreased compared to that of neurotypical participants. The selective decrease in performance for the viewpoint change condition suggests that face identity discrimination in autism is more difficult when access to local cues is minimized, and/or when dependence on integrative analysis is increased. These results lend support to a perceptual contribution of atypical face perception in autism. Autism Res 2015, 8: 497–506. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Atypical Face Perception in Autism: A Point of View? [Texte imprimé et/ou numérique] / Karine MORIN, Auteur ; Jacalyn GUY, Auteur ; Claudine HABAK, Auteur ; Hugh R. WILSON, Auteur ; Linda PAGANI, Auteur ; Laurent MOTTRON, Auteur ; Armando BERTONE, Auteur . - p.497-506. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.497-506 Mots-clés : autism spectrum disorder  face perception  local  global  synthetic faces  viewpoint change Index. décimale : PER Périodiques Résumé : Face perception is the most commonly used visual metric of social perception in autism. However, when found to be atypical, the origin of face perception differences in autism is contentious. One hypothesis proposes that a locally oriented visual analysis, characteristic of individuals with autism, ultimately affects performance on face tasks where a global analysis is optimal. The objective of this study was to evaluate this hypothesis by assessing face identity discrimination with synthetic faces presented with and without changes in viewpoint, with the former condition minimizing access to local face attributes used for identity discrimination. Twenty-eight individuals with autism and 30 neurotypical participants performed a face identity discrimination task. Stimuli were synthetic faces extracted from traditional face photographs in both front and 20° side viewpoints, digitized from 37 points to provide a continuous measure of facial geometry. Face identity discrimination thresholds were obtained using a two-alternative, temporal forced choice match-to-sample paradigm. Analyses revealed an interaction between group and condition, with group differences found only for the viewpoint change condition, where performance in the autism group was decreased compared to that of neurotypical participants. The selective decrease in performance for the viewpoint change condition suggests that face identity discrimination in autism is more difficult when access to local cues is minimized, and/or when dependence on integrative analysis is increased. These results lend support to a perceptual contribution of atypical face perception in autism. Autism Res 2015, 8: 497–506. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions / Mu YANG in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.507-521 Titre : 16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions Type de document : Texte imprimé et/ou numérique Auteurs : Mu YANG, Auteur ; Elena J. MAHRT, Auteur ; Freeman LEWIS, Auteur ; Gillian FOLEY, Auteur ; Thomas PORTMANN, Auteur ; Ricardo E. DOLMETSCH, Auteur ; Christine V. PORTFORS, Auteur ; Jacqueline N. CRAWLEY, Auteur Article en page(s) : p.507-521 Langues : Anglais (eng) Mots-clés : mouse model of autism  16p11.2 deletion  ultrasonic vocalization  social Interaction  autism Index. décimale : PER Périodiques Résumé : Recurrent deletions and duplications at chromosomal region 16p11.2 are variably associated with speech delay, autism spectrum disorder, developmental delay, schizophrenia, and cognitive impairments. Social communication deficits are a primary diagnostic symptom of autism. Here we investigated ultrasonic vocalizations (USVs) in young adult male 16p11.2 deletion mice during a novel three-phase male–female social interaction test that detects vocalizations emitted by a male in the presence of an estrous female, how the male changes its calling when the female is suddenly absent, and the extent to which calls resume when the female returns. Strikingly fewer vocalizations were detected in two independent cohorts of 16p11.2 heterozygous deletion males (+/?) during the first exposure to an unfamiliar estrous female, as compared to wildtype littermates (+/+). When the female was removed, +/+ emitted calls, but at a much lower level, whereas +/? males called minimally. Sensory and motor abnormalities were detected in +/?, including higher nociceptive thresholds, a complete absence of acoustic startle responses, and hearing loss in all +/? as confirmed by lack of auditory brainstem responses to frequencies between 8 and 100 kHz. Stereotyped circling and backflipping appeared in a small percentage of individuals, as previously reported. However, these sensory and motor phenotypes could not directly explain the low vocalizations in 16p11.2 deletion mice, since (a) +/? males displayed normal abilities to emit vocalizations when the female was subsequently reintroduced, and (b) +/? vocalized less than +/+ to social odor cues delivered on an inanimate cotton swab. Our findings support the concept that mouse USVs in social settings represent a response to social cues, and that 16p11.2 deletion mice are deficient in their initial USVs responses to novel social cues. Autism Res 2015, 8: 507–521. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] 16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions [Texte imprimé et/ou numérique] / Mu YANG, Auteur ; Elena J. MAHRT, Auteur ; Freeman LEWIS, Auteur ; Gillian FOLEY, Auteur ; Thomas PORTMANN, Auteur ; Ricardo E. DOLMETSCH, Auteur ; Christine V. PORTFORS, Auteur ; Jacqueline N. CRAWLEY, Auteur . - p.507-521. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.507-521 Mots-clés : mouse model of autism  16p11.2 deletion  ultrasonic vocalization  social Interaction  autism Index. décimale : PER Périodiques Résumé : Recurrent deletions and duplications at chromosomal region 16p11.2 are variably associated with speech delay, autism spectrum disorder, developmental delay, schizophrenia, and cognitive impairments. Social communication deficits are a primary diagnostic symptom of autism. Here we investigated ultrasonic vocalizations (USVs) in young adult male 16p11.2 deletion mice during a novel three-phase male–female social interaction test that detects vocalizations emitted by a male in the presence of an estrous female, how the male changes its calling when the female is suddenly absent, and the extent to which calls resume when the female returns. Strikingly fewer vocalizations were detected in two independent cohorts of 16p11.2 heterozygous deletion males (+/?) during the first exposure to an unfamiliar estrous female, as compared to wildtype littermates (+/+). When the female was removed, +/+ emitted calls, but at a much lower level, whereas +/? males called minimally. Sensory and motor abnormalities were detected in +/?, including higher nociceptive thresholds, a complete absence of acoustic startle responses, and hearing loss in all +/? as confirmed by lack of auditory brainstem responses to frequencies between 8 and 100 kHz. Stereotyped circling and backflipping appeared in a small percentage of individuals, as previously reported. However, these sensory and motor phenotypes could not directly explain the low vocalizations in 16p11.2 deletion mice, since (a) +/? males displayed normal abilities to emit vocalizations when the female was subsequently reintroduced, and (b) +/? vocalized less than +/+ to social odor cues delivered on an inanimate cotton swab. Our findings support the concept that mouse USVs in social settings represent a response to social cues, and that 16p11.2 deletion mice are deficient in their initial USVs responses to novel social cues. Autism Res 2015, 8: 507–521. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures / Jeremy R. PARR in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.522-533 Titre : New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy R. PARR, Auteur ; Maretha V. DE JONGE, Auteur ; Simon WALLACE, Auteur ; Andrew PICKLES, Auteur ; Michael L. RUTTER, Auteur ; Ann S. LE COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; Kerstin WITTEMEYER, Auteur ; Helen MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; Lennart PEDERSEN, Auteur ; Torben ISAGER, Auteur ; Fritz POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; Emma WEISBLATT, Auteur ; Jonathan GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; Gillian BAIRD, Auteur ; Anthony J. BAILEY, Auteur Article en page(s) : p.522-533 Langues : Anglais (eng) Mots-clés : broader autism phenotype  informant interview  self-report interview  interrater reliability  retest reliability Index. décimale : PER Périodiques Résumé : Clinical genetic studies confirm the broader autism phenotype (BAP) in some relatives of individuals with autism, but there are few standardized assessment measures. We developed three BAP measures (informant interview, self-report interview, and impression of interviewee observational scale) and describe the development strategy and findings from the interviews. International Molecular Genetic Study of Autism Consortium data were collected from families containing at least two individuals with autism. Comparison of the informant and self-report interviews was restricted to samples in which the interviews were undertaken by different researchers from that site (251 UK informants, 119 from the Netherlands). Researchers produced vignettes that were rated blind by others. Retest reliability was assessed in 45 participants. Agreement between live scoring and vignette ratings was very high. Retest stability for the interviews was high. Factor analysis indicated a first factor comprising social-communication items and rigidity (but not other repetitive domain items), and a second factor comprised mainly of reading and spelling impairments. Whole scale Cronbach's alphas were high for both interviews. The correlation between interviews for factor 1 was moderate (adult items 0.50; childhood items 0.43); Kappa values for between-interview agreement on individual items were mainly low. The correlations between individual items and total score were moderate. The inclusion of several factor 2 items lowered the overall Cronbach's alpha for the total set. Both interview measures showed good reliability and substantial stability over time, but the findings were better for factor 1 than factor 2. We recommend factor 1 scores be used for characterising the BAP. Autism Res 2015, 8: 522–533. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures [Texte imprimé et/ou numérique] / Jeremy R. PARR, Auteur ; Maretha V. DE JONGE, Auteur ; Simon WALLACE, Auteur ; Andrew PICKLES, Auteur ; Michael L. RUTTER, Auteur ; Ann S. LE COUTEUR, Auteur ; Herman VAN ENGELAND, Auteur ; Kerstin WITTEMEYER, Auteur ; Helen MCCONACHIE, Auteur ; Bernadette ROGE, Auteur ; Carine MANTOULAN, Auteur ; Lennart PEDERSEN, Auteur ; Torben ISAGER, Auteur ; Fritz POUSTKA, Auteur ; Sven BÖLTE, Auteur ; Patrick BOLTON, Auteur ; Emma WEISBLATT, Auteur ; Jonathan GREEN, Auteur ; Katerina PAPANIKOLAOU, Auteur ; Gillian BAIRD, Auteur ; Anthony J. BAILEY, Auteur . - p.522-533. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.522-533 Mots-clés : broader autism phenotype  informant interview  self-report interview  interrater reliability  retest reliability Index. décimale : PER Périodiques Résumé : Clinical genetic studies confirm the broader autism phenotype (BAP) in some relatives of individuals with autism, but there are few standardized assessment measures. We developed three BAP measures (informant interview, self-report interview, and impression of interviewee observational scale) and describe the development strategy and findings from the interviews. International Molecular Genetic Study of Autism Consortium data were collected from families containing at least two individuals with autism. Comparison of the informant and self-report interviews was restricted to samples in which the interviews were undertaken by different researchers from that site (251 UK informants, 119 from the Netherlands). Researchers produced vignettes that were rated blind by others. Retest reliability was assessed in 45 participants. Agreement between live scoring and vignette ratings was very high. Retest stability for the interviews was high. Factor analysis indicated a first factor comprising social-communication items and rigidity (but not other repetitive domain items), and a second factor comprised mainly of reading and spelling impairments. Whole scale Cronbach's alphas were high for both interviews. The correlation between interviews for factor 1 was moderate (adult items 0.50; childhood items 0.43); Kappa values for between-interview agreement on individual items were mainly low. The correlations between individual items and total score were moderate. The inclusion of several factor 2 items lowered the overall Cronbach's alpha for the total set. Both interview measures showed good reliability and substantial stability over time, but the findings were better for factor 1 than factor 2. We recommend factor 1 scores be used for characterising the BAP. Autism Res 2015, 8: 522–533. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Processing of Spontaneous Emotional Responses in Adolescents and Adults with Autism Spectrum Disorders: Effect of Stimulus Type / Sarah A. CASSIDY in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.534-544 Titre : Processing of Spontaneous Emotional Responses in Adolescents and Adults with Autism Spectrum Disorders: Effect of Stimulus Type Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A. CASSIDY, Auteur ; Peter MITCHELL, Auteur ; Peter CHAPMAN, Auteur ; Danielle ROPAR, Auteur Article en page(s) : p.534-544 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  face perception  eye tracking  spontaneous emotion recognition  retrodictive mindreading  social cognition  multi-modal processing  visual auditory integration Index. décimale : PER Périodiques Résumé : Recent research has shown that adults with autism spectrum disorders (ASD) have difficulty interpreting others' emotional responses, in order to work out what actually happened to them. It is unclear what underlies this difficulty; important cues may be missed from fast paced dynamic stimuli, or spontaneous emotional responses may be too complex for those with ASD to successfully recognise. To explore these possibilities, 17 adolescents and adults with ASD and 17 neurotypical controls viewed 21 videos and pictures of peoples' emotional responses to gifts (chocolate, a handmade novelty or Monopoly money), then inferred what gift the person received and the emotion expressed by the person while eye movements were measured. Participants with ASD were significantly more accurate at distinguishing who received a chocolate or homemade gift from static (compared to dynamic) stimuli, but significantly less accurate when inferring who received Monopoly money from static (compared to dynamic) stimuli. Both groups made similar emotion attributions to each gift in both conditions (positive for chocolate, feigned positive for homemade and confused for Monopoly money). Participants with ASD only made marginally significantly fewer fixations to the eyes of the face, and face of the person than typical controls in both conditions. Results suggest adolescents and adults with ASD can distinguish subtle emotion cues for certain emotions (genuine from feigned positive) when given sufficient processing time, however, dynamic cues are informative for recognising emotion blends (e.g. smiling in confusion). This indicates difficulties processing complex emotion responses in ASD. Autism Res 2015, 8: 534–544. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Processing of Spontaneous Emotional Responses in Adolescents and Adults with Autism Spectrum Disorders: Effect of Stimulus Type [Texte imprimé et/ou numérique] / Sarah A. CASSIDY, Auteur ; Peter MITCHELL, Auteur ; Peter CHAPMAN, Auteur ; Danielle ROPAR, Auteur . - p.534-544. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.534-544 Mots-clés : autism spectrum disorders  face perception  eye tracking  spontaneous emotion recognition  retrodictive mindreading  social cognition  multi-modal processing  visual auditory integration Index. décimale : PER Périodiques Résumé : Recent research has shown that adults with autism spectrum disorders (ASD) have difficulty interpreting others' emotional responses, in order to work out what actually happened to them. It is unclear what underlies this difficulty; important cues may be missed from fast paced dynamic stimuli, or spontaneous emotional responses may be too complex for those with ASD to successfully recognise. To explore these possibilities, 17 adolescents and adults with ASD and 17 neurotypical controls viewed 21 videos and pictures of peoples' emotional responses to gifts (chocolate, a handmade novelty or Monopoly money), then inferred what gift the person received and the emotion expressed by the person while eye movements were measured. Participants with ASD were significantly more accurate at distinguishing who received a chocolate or homemade gift from static (compared to dynamic) stimuli, but significantly less accurate when inferring who received Monopoly money from static (compared to dynamic) stimuli. Both groups made similar emotion attributions to each gift in both conditions (positive for chocolate, feigned positive for homemade and confused for Monopoly money). Participants with ASD only made marginally significantly fewer fixations to the eyes of the face, and face of the person than typical controls in both conditions. Results suggest adolescents and adults with ASD can distinguish subtle emotion cues for certain emotions (genuine from feigned positive) when given sufficient processing time, however, dynamic cues are informative for recognising emotion blends (e.g. smiling in confusion). This indicates difficulties processing complex emotion responses in ASD. Autism Res 2015, 8: 534–544. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model / Jacob ELLEGOOD in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.545-555 Titre : Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model Type de document : Texte imprimé et/ou numérique Auteurs : Jacob ELLEGOOD, Auteur ; Nobuhiro NAKAI, Auteur ; Jin NAKATANI, Auteur ; Mark HENKELMAN, Auteur ; Toru TAKUMI, Auteur ; Jason LERCH, Auteur Article en page(s) : p.545-555 Langues : Anglais (eng) Mots-clés : animal models  structural MRI  neuroanatomy  copy number variation  molecular genetics  15q11-13 duplication Index. décimale : PER Périodiques Résumé : Paternally and maternally inherited deletions and duplications of human chromosome 15q11-13 are relatively common in the human population. Furthermore, duplications in the 15q region are often associated with autism. Both maternal and paternal interstitial 15q11-13 duplication mouse models have been previously created, where several behavioral differences were found in the paternal duplication (patDp/+) mouse but not in the maternal duplication (matDp/+). These included decreased sociability, behavioral inflexibility, abnormal ultrasonic vocalizations, decreased spontaneous activity, and increased anxiety. Similarly, in the current study, we found several anatomical differences in the patDp/+ mice that were not seen in the matDp/+ mice. Regional differences that are evident only in the paternal duplication are a smaller dentate gyrus and smaller medial striatum. These differences may be responsible for the behavioral inflexibility. Furthermore, a smaller dorsal raphe nucleus could be responsible for the reported serotonin defects. This study highlights consistency that can be found between behavioral and anatomical phenotyping. Autism Res 2015, 8: 545–555. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Neuroanatomical Phenotypes Are Consistent With Autism-Like Behavioral Phenotypes in the 15q11-13 Duplication Mouse Model [Texte imprimé et/ou numérique] / Jacob ELLEGOOD, Auteur ; Nobuhiro NAKAI, Auteur ; Jin NAKATANI, Auteur ; Mark HENKELMAN, Auteur ; Toru TAKUMI, Auteur ; Jason LERCH, Auteur . - p.545-555. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.545-555 Mots-clés : animal models  structural MRI  neuroanatomy  copy number variation  molecular genetics  15q11-13 duplication Index. décimale : PER Périodiques Résumé : Paternally and maternally inherited deletions and duplications of human chromosome 15q11-13 are relatively common in the human population. Furthermore, duplications in the 15q region are often associated with autism. Both maternal and paternal interstitial 15q11-13 duplication mouse models have been previously created, where several behavioral differences were found in the paternal duplication (patDp/+) mouse but not in the maternal duplication (matDp/+). These included decreased sociability, behavioral inflexibility, abnormal ultrasonic vocalizations, decreased spontaneous activity, and increased anxiety. Similarly, in the current study, we found several anatomical differences in the patDp/+ mice that were not seen in the matDp/+ mice. Regional differences that are evident only in the paternal duplication are a smaller dentate gyrus and smaller medial striatum. These differences may be responsible for the behavioral inflexibility. Furthermore, a smaller dorsal raphe nucleus could be responsible for the reported serotonin defects. This study highlights consistency that can be found between behavioral and anatomical phenotyping. Autism Res 2015, 8: 545–555. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay / Joana Bisol BALARDIN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.556-566 Titre : Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay Type de document : Texte imprimé et/ou numérique Auteurs : Joana Bisol BALARDIN, Auteur ; João Ricardo SATO, Auteur ; Gilson VIEIRA, Auteur ; Yeu FENG, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Declan MURPHY, Auteur ; Christine ECKER, Auteur Article en page(s) : p.556-566 Langues : Anglais (eng) Mots-clés : autism  Asperger syndrome  brain anatomy  intelligence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the autism spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of ASD. In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in ASD individuals with and without a history of language delay. We included 64 ASD adults of normal intelligence (37 without a history of language delay and 27 with a history of language delay and 80 neurotypicals). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with ASD and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between ASD individuals with and without a history of language delay in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that ASD subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. Autism Res 2015, 8: 556–566. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay [Texte imprimé et/ou numérique] / Joana Bisol BALARDIN, Auteur ; João Ricardo SATO, Auteur ; Gilson VIEIRA, Auteur ; Yeu FENG, Auteur ; Eileen DALY, Auteur ; Clodagh M. MURPHY, Auteur ; Mrc Aims CONSORTIUM, Auteur ; Declan MURPHY, Auteur ; Christine ECKER, Auteur . - p.556-566. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.556-566 Mots-clés : autism  Asperger syndrome  brain anatomy  intelligence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of conditions that show abnormalities in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the autism spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of ASD. In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in ASD individuals with and without a history of language delay. We included 64 ASD adults of normal intelligence (37 without a history of language delay and 27 with a history of language delay and 80 neurotypicals). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with ASD and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between ASD individuals with and without a history of language delay in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that ASD subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. Autism Res 2015, 8: 556–566. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study / Kristen LYALL in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.567-574 Titre : Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Article en page(s) : p.567-574 Langues : Anglais (eng) Mots-clés : autism  asthma  allergy  food allergy Index. décimale : PER Périodiques Résumé : Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - p.567-574. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.567-574 Mots-clés : autism  asthma  allergy  food allergy Index. décimale : PER Périodiques Résumé : Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1471 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

A Point of Departure in the Comparison of Social and Nonsocial Visual Orienting Among Persons With Autism Spectrum Disorders / Tara FLANAGAN in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.575-582 Titre : A Point of Departure in the Comparison of Social and Nonsocial Visual Orienting Among Persons With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Tara FLANAGAN, Auteur ; Darlene A. BRODEUR, Auteur ; Jacob A. BURACK, Auteur Article en page(s) : p.575-582 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  visual orienting  social orienting  Posner task Index. décimale : PER Périodiques Résumé : Endogenous visual orienting among children with autism spectrum disorders (ASDs) and among typically developing (TD) children was examined using a Posner-type task that was modified to include social and nonsocial cues and targets to test hypotheses regarding information (social or nonsocial) and cue processing (long or short stimulus onset asynchronies (SOAs)). The findings suggest intact endogenous orienting to face and mixed face targets using hand and arrow cues among children with ASDs who were matched to typically developing children (TDC) on the basis of nonverbal mental age (MA) at approximately 8.5 years. The findings from this study challenge the notions of a social orienting impairment and of mechanical social orienting as the children with ASDs in this study demonstrated strong orienting effects in all conditions and social sensitivity in the long stimulus onset asynchrony (SOA) condition. Autism Res 2015, 8: 575–582. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] A Point of Departure in the Comparison of Social and Nonsocial Visual Orienting Among Persons With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Tara FLANAGAN, Auteur ; Darlene A. BRODEUR, Auteur ; Jacob A. BURACK, Auteur . - p.575-582. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.575-582 Mots-clés : autism spectrum disorders  visual orienting  social orienting  Posner task Index. décimale : PER Périodiques Résumé : Endogenous visual orienting among children with autism spectrum disorders (ASDs) and among typically developing (TD) children was examined using a Posner-type task that was modified to include social and nonsocial cues and targets to test hypotheses regarding information (social or nonsocial) and cue processing (long or short stimulus onset asynchronies (SOAs)). The findings suggest intact endogenous orienting to face and mixed face targets using hand and arrow cues among children with ASDs who were matched to typically developing children (TDC) on the basis of nonverbal mental age (MA) at approximately 8.5 years. The findings from this study challenge the notions of a social orienting impairment and of mechanical social orienting as the children with ASDs in this study demonstrated strong orienting effects in all conditions and social sensitivity in the long stimulus onset asynchrony (SOA) condition. Autism Res 2015, 8: 575–582. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection / Vanessa H. BAL in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.583-592 Titre : Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa H. BAL, Auteur ; Catherine LORD, Auteur Article en page(s) : p.583-592 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  Autism Diagnostic Observation Schedule  severity  social affect  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Raw totals from diagnostic and screening measures for autism spectrum disorder (ASD) are frequently used as dimensional measures of autism symptom severity without appropriate correction for confounding factors, such as developmental level or non-ASD-specific behavior problems. Although these associated features are important to consider when diagnosing ASD and developing intervention plans, both researchers and clinicians sometimes need metrics of ASD severity that are not influenced by these factors. The Autism Diagnostic Observation Schedule (ADOS) domain calibrated severity scores (CSS) were created to provide separate estimates of social affect (SA-CSS) and restricted, repetitive behaviors (RRB-CSS) that are relatively independent of child characteristics (Hus et al., 2014). Using a sample of 2,509 probands with ASD from the Simons Simplex Collection (SSC), this study provides the first replication of the ADOS domain CSS in an independent sample. Consistent with the original standardization study, when applied to existing SSC data, the ADOS domain CSS were less influenced by age and cognitive ability compared to raw domain totals. Domain CSS were also relatively independent of behavior problems. Use of the ADOS domain CSS to assess relationships between ASD symptoms and genetic risk factors will increase confidence that associations reflect domain-specific relationships. Scores also offer less developmentally-influenced estimates of ASD severity for future phenotypic explorations in the SSC. This independent replication provides support for the application of the ADOS domain CSS in other samples, though further replication in population-based samples will be an important next step. Autism Res 2015, 8: 583–592. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Replication of Standardized ADOS Domain Scores in the Simons Simplex Collection [Texte imprimé et/ou numérique] / Vanessa H. BAL, Auteur ; Catherine LORD, Auteur . - p.583-592. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.583-592 Mots-clés : autism spectrum disorder  Autism Diagnostic Observation Schedule  severity  social affect  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Raw totals from diagnostic and screening measures for autism spectrum disorder (ASD) are frequently used as dimensional measures of autism symptom severity without appropriate correction for confounding factors, such as developmental level or non-ASD-specific behavior problems. Although these associated features are important to consider when diagnosing ASD and developing intervention plans, both researchers and clinicians sometimes need metrics of ASD severity that are not influenced by these factors. The Autism Diagnostic Observation Schedule (ADOS) domain calibrated severity scores (CSS) were created to provide separate estimates of social affect (SA-CSS) and restricted, repetitive behaviors (RRB-CSS) that are relatively independent of child characteristics (Hus et al., 2014). Using a sample of 2,509 probands with ASD from the Simons Simplex Collection (SSC), this study provides the first replication of the ADOS domain CSS in an independent sample. Consistent with the original standardization study, when applied to existing SSC data, the ADOS domain CSS were less influenced by age and cognitive ability compared to raw domain totals. Domain CSS were also relatively independent of behavior problems. Use of the ADOS domain CSS to assess relationships between ASD symptoms and genetic risk factors will increase confidence that associations reflect domain-specific relationships. Scores also offer less developmentally-influenced estimates of ASD severity for future phenotypic explorations in the SSC. This independent replication provides support for the application of the ADOS domain CSS in other samples, though further replication in population-based samples will be an important next step. Autism Res 2015, 8: 583–592. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Meta-Analysis of Gene Expression in Autism Spectrum Disorder / Carolyn CH'NG in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.593-608 Titre : Meta-Analysis of Gene Expression in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn CH'NG, Auteur ; Willie KWOK, Auteur ; Sanja ROGIC, Auteur ; Paul PAVLIDIS, Auteur Article en page(s) : p.593-608 Langues : Anglais (eng) Mots-clés : gene expression  meta-analysis  molecular genetics  microarray Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are clinically heterogeneous and biologically complex. In general it remains unclear, what biological factors lead to changes in the brains of autistic individuals. A considerable number of transcriptome analyses have been performed in attempts to address this question, but their findings lack a clear consensus. As a result, each of these individual studies has not led to any significant advance in understanding the autistic phenotype as a whole. Here, we report a meta-analysis of more than 1000 microarrays across twelve independent studies on expression changes in ASD compared to unaffected individuals, in both blood and brain tissues. We identified a number of known and novel genes that are consistently differentially expressed across three studies of the brain (71 samples in total). A subset of the highly ranked genes is suggestive of effects on mitochondrial function. In blood, consistent changes were more difficult to identify, despite individual studies tending to exhibit larger effects than the brain studies. Our results are the strongest evidence to date of a common transcriptome signature in the brains of individuals with ASD. Autism Res 2015, 8: 593–608. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Meta-Analysis of Gene Expression in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Carolyn CH'NG, Auteur ; Willie KWOK, Auteur ; Sanja ROGIC, Auteur ; Paul PAVLIDIS, Auteur . - p.593-608. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.593-608 Mots-clés : gene expression  meta-analysis  molecular genetics  microarray Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are clinically heterogeneous and biologically complex. In general it remains unclear, what biological factors lead to changes in the brains of autistic individuals. A considerable number of transcriptome analyses have been performed in attempts to address this question, but their findings lack a clear consensus. As a result, each of these individual studies has not led to any significant advance in understanding the autistic phenotype as a whole. Here, we report a meta-analysis of more than 1000 microarrays across twelve independent studies on expression changes in ASD compared to unaffected individuals, in both blood and brain tissues. We identified a number of known and novel genes that are consistently differentially expressed across three studies of the brain (71 samples in total). A subset of the highly ranked genes is suggestive of effects on mitochondrial function. In blood, consistent changes were more difficult to identify, despite individual studies tending to exhibit larger effects than the brain studies. Our results are the strongest evidence to date of a common transcriptome signature in the brains of individuals with ASD. Autism Res 2015, 8: 593–608. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1475 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Object-location memory in adults with autism spectrum disorder / Melanie RING in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.609-619 Titre : Object-location memory in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melanie RING, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur Article en page(s) : p.609-619 Langues : Anglais (eng) Mots-clés : explicit relational memory  implicit relational memory  Autism Spectrum Disorder  recognition memory  source memory  task support hypothesis  process-dissociation procedure Index. décimale : PER Périodiques Résumé : This study tested implicit and explicit spatial relational memory in Autism Spectrum Disorder (ASD). Participants were asked to study pictures of rooms and pictures of daily objects for which locations were highlighted in the rooms. Participants were later tested for their memory of the object locations either by being asked to place objects back into their original locations or into new locations. Proportions of times when participants choose the previously studied locations for the objects irrespective of the instruction were used to derive indices of explicit and implicit memory [process-dissociation procedure, Jacoby, 1991, 1998]. In addition, participants performed object and location recognition and source memory tasks where they were asked about which locations belonged to the objects and which objects to the locations. The data revealed difficulty for ASD individuals in actively retrieving object locations (explicit memory) but not in subconsciously remembering them (implicit memory). These difficulties cannot be explained by difficulties in memory for objects or locations per se (i.e., the difficulty pertains to object-location relations). Together these observations lend further support to the idea that ASD is characterised by relatively circumscribed difficulties in relational rather than item-specific memory processes and show that these difficulties extend to the domain of spatial information. They also lend further support to the idea that memory difficulties in ASD can be reduced when support is provided at test. Autism Res 2015, 8: 609–619. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Object-location memory in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Melanie RING, Auteur ; Sebastian B. GAIGG, Auteur ; Dermot M. BOWLER, Auteur . - p.609-619. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.609-619 Mots-clés : explicit relational memory  implicit relational memory  Autism Spectrum Disorder  recognition memory  source memory  task support hypothesis  process-dissociation procedure Index. décimale : PER Périodiques Résumé : This study tested implicit and explicit spatial relational memory in Autism Spectrum Disorder (ASD). Participants were asked to study pictures of rooms and pictures of daily objects for which locations were highlighted in the rooms. Participants were later tested for their memory of the object locations either by being asked to place objects back into their original locations or into new locations. Proportions of times when participants choose the previously studied locations for the objects irrespective of the instruction were used to derive indices of explicit and implicit memory [process-dissociation procedure, Jacoby, 1991, 1998]. In addition, participants performed object and location recognition and source memory tasks where they were asked about which locations belonged to the objects and which objects to the locations. The data revealed difficulty for ASD individuals in actively retrieving object locations (explicit memory) but not in subconsciously remembering them (implicit memory). These difficulties cannot be explained by difficulties in memory for objects or locations per se (i.e., the difficulty pertains to object-location relations). Together these observations lend further support to the idea that ASD is characterised by relatively circumscribed difficulties in relational rather than item-specific memory processes and show that these difficulties extend to the domain of spatial information. They also lend further support to the idea that memory difficulties in ASD can be reduced when support is provided at test. Autism Res 2015, 8: 609–619. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters / Coralie CHEVALLIER in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.620-628 Titre : Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters Type de document : Texte imprimé et/ou numérique Auteurs : Coralie CHEVALLIER, Auteur ; Julia PARISH-MORRIS, Auteur ; Alana MCVEY, Auteur ; Keiran M. RUMP, Auteur ; Noah J. SASSON, Auteur ; John D. HERRINGTON, Auteur ; Robert T. SCHULTZ, Auteur Article en page(s) : p.620-628 Langues : Anglais (eng) Mots-clés : social attention  autism spectrum disorder  eye-tracking  social motivation  methodology  face processing Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by social impairments that have been related to deficits in social attention, including diminished gaze to faces. Eye-tracking studies are commonly used to examine social attention and social motivation in ASD, but they vary in sensitivity. In this study, we hypothesized that the ecological nature of the social stimuli would affect participants' social attention, with gaze behavior during more naturalistic scenes being most predictive of ASD vs. typical development. Eighty-one children with and without ASD participated in three eye-tracking tasks that differed in the ecological relevance of the social stimuli. In the “Static Visual Exploration” task, static images of objects and people were presented; in the “Dynamic Visual Exploration” task, video clips of individual faces and objects were presented side-by-side; in the “Interactive Visual Exploration” task, video clips of children playing with objects in a naturalistic context were presented. Our analyses uncovered a three-way interaction between Task, Social vs. Object Stimuli, and Diagnosis. This interaction was driven by group differences on one task only—the Interactive task. Bayesian analyses confirmed that the other two tasks were insensitive to group membership. In addition, receiver operating characteristic analyses demonstrated that, unlike the other two tasks, the Interactive task had significant classification power. The ecological relevance of social stimuli is an important factor to consider for eye-tracking studies aiming to measure social attention and motivation in ASD. Autism Res 2015, 8: 620–628. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters [Texte imprimé et/ou numérique] / Coralie CHEVALLIER, Auteur ; Julia PARISH-MORRIS, Auteur ; Alana MCVEY, Auteur ; Keiran M. RUMP, Auteur ; Noah J. SASSON, Auteur ; John D. HERRINGTON, Auteur ; Robert T. SCHULTZ, Auteur . - p.620-628. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.620-628 Mots-clés : social attention  autism spectrum disorder  eye-tracking  social motivation  methodology  face processing Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by social impairments that have been related to deficits in social attention, including diminished gaze to faces. Eye-tracking studies are commonly used to examine social attention and social motivation in ASD, but they vary in sensitivity. In this study, we hypothesized that the ecological nature of the social stimuli would affect participants' social attention, with gaze behavior during more naturalistic scenes being most predictive of ASD vs. typical development. Eighty-one children with and without ASD participated in three eye-tracking tasks that differed in the ecological relevance of the social stimuli. In the “Static Visual Exploration” task, static images of objects and people were presented; in the “Dynamic Visual Exploration” task, video clips of individual faces and objects were presented side-by-side; in the “Interactive Visual Exploration” task, video clips of children playing with objects in a naturalistic context were presented. Our analyses uncovered a three-way interaction between Task, Social vs. Object Stimuli, and Diagnosis. This interaction was driven by group differences on one task only—the Interactive task. Bayesian analyses confirmed that the other two tasks were insensitive to group membership. In addition, receiver operating characteristic analyses demonstrated that, unlike the other two tasks, the Interactive task had significant classification power. The ecological relevance of social stimuli is an important factor to consider for eye-tracking studies aiming to measure social attention and motivation in ASD. Autism Res 2015, 8: 620–628. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo / Vladimir GRUBIŠI? in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.629-633 Titre : Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo Type de document : Texte imprimé et/ou numérique Auteurs : Vladimir GRUBIŠI?, Auteur ; Andrew J. KENNEDY, Auteur ; J. David SWEATT, Auteur ; Vladimir PARPURA, Auteur Article en page(s) : p.629-633 Langues : Anglais (eng) Mots-clés : PTHS mouse model  gut transit  TCF4  E2-2  ITF2 Index. décimale : PER Périodiques Résumé : Pitt–Hopkins syndrome (PTHS) is a neurodevelopmental disorder, classified as an autism spectrum disorder that is caused by the haploinsufficiency of Transcription Factor 4 (TCF4). The most common non-neurological symptoms in PTHS patients are gastrointestinal (GI) disturbances, mainly gastroesophageal reflux and severe constipation (in about 30 and 75% of PTHS patients, respectively). We hypothesized that the recently recognized mouse model of PTHS will exhibit problems with their gut function. We conducted series of in vivo tests on 15- to 19- week old male mice, heterozygous for the TCF4 functional deletion, mimicking the TCF4 haploinsufficiency in PTHS patients, and their wild type littermates. Data collection and initial analysis were performed blindly, that is, the genotyping key was received after the mean values were calculated for each individual animal, and then mean/median of each group was subsequently calculated. Body weight, fecal pellet output, and fluid content were similar between the groups, indicating normal gross growth of PTHS mice and their overall physiological GI motility and intestinal secretion/absorption. There were no significant differences in gut length and gross appearance pointing out that PTHS mice have normal gut in gross anatomical terms. However, the assessment of gut transit indicates that, while whole-gut transit velocity was similar between the groups, the upper GI and distal colon transit velocities were significantly reduced in the PTHS mice. This is the first evidence of specific gut related problems in the PTHS mice. Our study also validates the TCF4 functional knockout mice as an animal model to study PTHS-associated GI disturbances. Autism Res 2015, 8: 629–633. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Pitt–Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo [Texte imprimé et/ou numérique] / Vladimir GRUBIŠI?, Auteur ; Andrew J. KENNEDY, Auteur ; J. David SWEATT, Auteur ; Vladimir PARPURA, Auteur . - p.629-633. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.629-633 Mots-clés : PTHS mouse model  gut transit  TCF4  E2-2  ITF2 Index. décimale : PER Périodiques Résumé : Pitt–Hopkins syndrome (PTHS) is a neurodevelopmental disorder, classified as an autism spectrum disorder that is caused by the haploinsufficiency of Transcription Factor 4 (TCF4). The most common non-neurological symptoms in PTHS patients are gastrointestinal (GI) disturbances, mainly gastroesophageal reflux and severe constipation (in about 30 and 75% of PTHS patients, respectively). We hypothesized that the recently recognized mouse model of PTHS will exhibit problems with their gut function. We conducted series of in vivo tests on 15- to 19- week old male mice, heterozygous for the TCF4 functional deletion, mimicking the TCF4 haploinsufficiency in PTHS patients, and their wild type littermates. Data collection and initial analysis were performed blindly, that is, the genotyping key was received after the mean values were calculated for each individual animal, and then mean/median of each group was subsequently calculated. Body weight, fecal pellet output, and fluid content were similar between the groups, indicating normal gross growth of PTHS mice and their overall physiological GI motility and intestinal secretion/absorption. There were no significant differences in gut length and gross appearance pointing out that PTHS mice have normal gut in gross anatomical terms. However, the assessment of gut transit indicates that, while whole-gut transit velocity was similar between the groups, the upper GI and distal colon transit velocities were significantly reduced in the PTHS mice. This is the first evidence of specific gut related problems in the PTHS mice. Our study also validates the TCF4 functional knockout mice as an animal model to study PTHS-associated GI disturbances. Autism Res 2015, 8: 629–633. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Association and Promoter Analysis of AVPR1A in Finnish Autism Families / Katri KANTOJARVI in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.634-639 Titre : Association and Promoter Analysis of AVPR1A in Finnish Autism Families Type de document : Texte imprimé et/ou numérique Auteurs : Katri KANTOJARVI, Auteur ; Jaana OIKKONEN, Auteur ; Ilona KOTALA, Auteur ; Jenni KALLELA, Auteur ; Raija VANHALA, Auteur ; Päivi ONKAMO, Auteur ; Irma JARVELA, Auteur Article en page(s) : p.634-639 Langues : Anglais (eng) Mots-clés : autism  AVPR1A  association  transcription factors  network analysis  promoter analysis  MEF2C  PBX Index. décimale : PER Périodiques Résumé : The arginine vasopressin receptor 1A gene (AVPR1A) is known to affect social communication and has been reported to associate with autism in several studies. Given that the microsatellite RS1 and a few SNPs in the promoter region of the AVPR1A have repeatedly associated with several traits, including autism it is rather surprising that the molecular explanation for these associations has remained unknown, although it has been reported that the allele length of the AVPR1A microsatellites might affect disease risk. Here we carried out an extended association analysis of three microsatellites and 12 tag single nucleotide polymorphisms (SNPs) in and around the AVPR1A gene in 205 Finnish families followed by promoter analysis. FBAT version v2.0.3 was used for family-based genetic association analyses of AVPR1A microsatellites and SNPs. The nearby microsatellite RS1 was found to harbor the best association. Interestingly, there are two potentially relevant transcription factor (TF) binding sites at RS1: for MEF2C and PBX, predicted with the Match algorithm in the TRANSFAC® database. Sequence variations changing the affinity of these TFs might partly explain the AVPR1A promoter region associations shown in autism. Autism Res 2015, 8: 634–639. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1473 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Association and Promoter Analysis of AVPR1A in Finnish Autism Families [Texte imprimé et/ou numérique] / Katri KANTOJARVI, Auteur ; Jaana OIKKONEN, Auteur ; Ilona KOTALA, Auteur ; Jenni KALLELA, Auteur ; Raija VANHALA, Auteur ; Päivi ONKAMO, Auteur ; Irma JARVELA, Auteur . - p.634-639. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.634-639 Mots-clés : autism  AVPR1A  association  transcription factors  network analysis  promoter analysis  MEF2C  PBX Index. décimale : PER Périodiques Résumé : The arginine vasopressin receptor 1A gene (AVPR1A) is known to affect social communication and has been reported to associate with autism in several studies. Given that the microsatellite RS1 and a few SNPs in the promoter region of the AVPR1A have repeatedly associated with several traits, including autism it is rather surprising that the molecular explanation for these associations has remained unknown, although it has been reported that the allele length of the AVPR1A microsatellites might affect disease risk. Here we carried out an extended association analysis of three microsatellites and 12 tag single nucleotide polymorphisms (SNPs) in and around the AVPR1A gene in 205 Finnish families followed by promoter analysis. FBAT version v2.0.3 was used for family-based genetic association analyses of AVPR1A microsatellites and SNPs. The nearby microsatellite RS1 was found to harbor the best association. Interestingly, there are two potentially relevant transcription factor (TF) binding sites at RS1: for MEF2C and PBX, predicted with the Match algorithm in the TRANSFAC® database. Sequence variations changing the affinity of these TFs might partly explain the AVPR1A promoter region associations shown in autism. Autism Res 2015, 8: 634–639. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1473 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Scientific Summaries for Families with ASD in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.640-646 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.640-646 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.640-646. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.640-646 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

International Society for Autism Research News in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.647-647 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Article en page(s) : p.647-647 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - p.647-647. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.647-647 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1577 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Issue Information in Autism Research, 8-5 (October 2015)  

Public ISBD [article]  inAutism Research > 8-5 (October 2015) . - p.n/a-n/a Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.n/a-n/a Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Issue Information [Texte imprimé et/ou numérique] . - p.n/a-n/a. Langues : Anglais (eng) in Autism Research > 8-5 (October 2015) . - p.n/a-n/a Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1419 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270