Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm / Simona SPINELLI in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.977-987 Titre : Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Timothy K. NEWMAN, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur Année de publication : 2007 Article en page(s) : p.977-987 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the short (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4-day long social separations for 4 consecutive weeks, with 3 days of reunion in between. Data were collected during both the acute (Day 1) and chronic phases (Days 2–4) of separation. Behavioral factors were separately extracted for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviors, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carriers of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity. En ligne : http://dx.doi.org/10.1017/s095457940700048x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 [article] Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Timothy K. NEWMAN, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur . - 2007 . - p.977-987. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.977-987 Index. décimale : PER Périodiques Résumé : Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression. Relative to the long (l) allele, the short (s) allele increases the risk of developing depression in individuals exposed to stressful life events. An orthologue of the human variant is present in rhesus macaques and allows for studies in animals exposed to stress. Here, we used an established model of early life stress exposure, in which rhesus macaques are raised without adults in a group of peers (peer-only reared [PR]), or with their mothers. At 6 months of age, animals were subjected to 4-day long social separations for 4 consecutive weeks, with 3 days of reunion in between. Data were collected during both the acute (Day 1) and chronic phases (Days 2–4) of separation. Behavioral factors were separately extracted for each phase of separation. For acute separation, the behavioral factors generated were despair and behavioral pathology and, for the chronic phase despair, agitation, and behavioral pathology. During both phases of social separation, PR l/s animals were more likely to exhibit pathological behaviors, whereas PR l/l monkeys show higher levels of despair compared to the other three groups. These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype and suggest that carriers of the s allele are not only more anxious but may also be more vulnerable to developing behavioral pathology in the face of chronic adversity. En ligne : http://dx.doi.org/10.1017/s095457940700048x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction / Stephen G. LINDELL in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1391-1400 Titre : The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction Type de document : Texte imprimé et/ou numérique Auteurs : Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur Année de publication : 2012 Article en page(s) : p.1391-1400 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In humans, it has been demonstrated that the serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates risk in the face of adversity. One mechanism by which stress could interact with genotype is via epigenetic modifications. We wanted to examine whether stress interacted with genotype to predict binding of a histone 3 protein trimethylated at lysine 3 (H3K4me3) that marks active promoters. The brains (N = 61) of male rhesus macaques that had been reared in the presence or absence of stress were archived and the hippocampusi dissected. Chromatin immunoprecipitation was performed with an antibody against H3K4me3 followed by sequencing on a SolexaG2A. The effects of age, genotype (5-HTTLPR long/long vs. short), and stress exposure (peer-reared vs. mother-reared) on levels of H3K4me3 binding were determined. We found effects of age and stress exposure. There was a decline in H3K4me3 from preadolescence to postadolescence and lower levels in peer-reared monkeys and no effects of genotype. When we controlled for age, however, we found that there were effects of 5-HTTLPR genotype and rearing condition on H3K4me3 binding. In a larger sample, we observed that cerebrospinal fluid 5-hydroxyindoleacetic acid levels were subject to interactive effects among age, rearing history, and genotype. Genes containing both genetic selection and epigenetic regulation may be particularly important in stress adaptation and development. We find evidence for selection at the solute carrier family C6 member 4 gene and observe epigenetic reorganization according to genotype, stress, and age. These data suggest that developmental stage may moderate effects of stress and serotonin transporter genotype in the emergence of alternative adaptation strategies and in the vulnerability to developmental or psychiatric disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interaction [Texte imprimé et/ou numérique] / Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur . - 2012 . - p.1391-1400. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1391-1400 Index. décimale : PER Périodiques Résumé : In humans, it has been demonstrated that the serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates risk in the face of adversity. One mechanism by which stress could interact with genotype is via epigenetic modifications. We wanted to examine whether stress interacted with genotype to predict binding of a histone 3 protein trimethylated at lysine 3 (H3K4me3) that marks active promoters. The brains (N = 61) of male rhesus macaques that had been reared in the presence or absence of stress were archived and the hippocampusi dissected. Chromatin immunoprecipitation was performed with an antibody against H3K4me3 followed by sequencing on a SolexaG2A. The effects of age, genotype (5-HTTLPR long/long vs. short), and stress exposure (peer-reared vs. mother-reared) on levels of H3K4me3 binding were determined. We found effects of age and stress exposure. There was a decline in H3K4me3 from preadolescence to postadolescence and lower levels in peer-reared monkeys and no effects of genotype. When we controlled for age, however, we found that there were effects of 5-HTTLPR genotype and rearing condition on H3K4me3 binding. In a larger sample, we observed that cerebrospinal fluid 5-hydroxyindoleacetic acid levels were subject to interactive effects among age, rearing history, and genotype. Genes containing both genetic selection and epigenetic regulation may be particularly important in stress adaptation and development. We find evidence for selection at the solute carrier family C6 member 4 gene and observe epigenetic reorganization according to genotype, stress, and age. These data suggest that developmental stage may moderate effects of stress and serotonin transporter genotype in the emergence of alternative adaptation strategies and in the vulnerability to developmental or psychiatric disorders. En ligne : http://dx.doi.org/10.1017/S0954579412000788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interactions—CORRIGENDUM / Stephen G. LINDELL in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1181-1181 Titre : The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interactions—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur Année de publication : 2014 Article en page(s) : p.1181-1181 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000583 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: Potential roles in genetic selection and Gene × Environment interactions—CORRIGENDUM [Texte imprimé et/ou numérique] / Stephen G. LINDELL, Auteur ; Qiaoping YUAN, Auteur ; Zhifeng ZHOU, Auteur ; David GOLDMAN, Auteur ; Robert C. THOMPSON, Auteur ; Juan F. LOPEZ, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; Christina S. BARR, Auteur . - 2014 . - p.1181-1181. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1181-1181 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000583 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques / Simona SPINELLI in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.157-165 Titre : The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur Année de publication : 2012 Article en page(s) : p.157-165 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5-HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across four successive separations. Males increased their levels of locomotion with repeated maternal separation, whereas females exhibited an increase in frequency of self-directed behavior, a measure of “depression-like” behavior. The short-allele predicted increased environmental exploration, particularly during the chronic phase of social separation, indicative of higher arousal. In addition, the short-allele carriers were more likely to increase their levels of self-directed behavior during the chronic phase of separation, as a function of repeated exposures. These findings suggest that the short allele may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable. En ligne : http://dx.doi.org/10.1017/S0954579411000745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Melanie L. SCHWANDT, Auteur ; Stephen G. LINDELL, Auteur ; Markus HEILIG, Auteur ; Stephen J. SUOMI, Auteur ; J. Dee HIGLEY, Auteur ; David GOLDMAN, Auteur ; Christina S. BARR, Auteur . - 2012 . - p.157-165. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.157-165 Index. décimale : PER Périodiques Résumé : The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5-HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across four successive separations. Males increased their levels of locomotion with repeated maternal separation, whereas females exhibited an increase in frequency of self-directed behavior, a measure of “depression-like” behavior. The short-allele predicted increased environmental exploration, particularly during the chronic phase of social separation, indicative of higher arousal. In addition, the short-allele carriers were more likely to increase their levels of self-directed behavior during the chronic phase of separation, as a function of repeated exposures. These findings suggest that the short allele may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable. En ligne : http://dx.doi.org/10.1017/S0954579411000745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

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