Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD / Agatha LENARTOWICZ in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Titre : Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD Type de document : texte imprimé Auteurs : Agatha LENARTOWICZ, Auteur ; Holly TRUONG, Auteur ; Giulia C. SALGARI, Auteur ; Robert M. BILDER, Auteur ; James MCGOUGH, Auteur ; James T. MCCRACKEN, Auteur ; Sandra K. LOO, Auteur Article en page(s) : p.917-926 Langues : Anglais (eng) Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD [texte imprimé] / Agatha LENARTOWICZ, Auteur ; Holly TRUONG, Auteur ; Giulia C. SALGARI, Auteur ; Robert M. BILDER, Auteur ; James MCGOUGH, Auteur ; James T. MCCRACKEN, Auteur ; Sandra K. LOO, Auteur . - p.917-926. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

Research Review: Use of EEG biomarkers in child psychiatry research – current state and future directions / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.4-17 Titre : Research Review: Use of EEG biomarkers in child psychiatry research – current state and future directions Type de document : texte imprimé Auteurs : Sandra K. LOO, Auteur ; Agatha LENARTOWICZ, Auteur ; Scott MAKEIG, Auteur Article en page(s) : p.4-17 Langues : Anglais (eng) Mots-clés : EEG  event-related potential  brain imaging  neurophysiology  psychopathology Index. décimale : PER Périodiques Résumé : Background Electroencephalography (EEG) and related measures have a long and productive history in child psychopathology research and are currently experiencing a renaissance in interest, particularly for use as putative biomarkers. Method and Scope First, the recent history leading to the use of EEG measures as endophenotypes and biomarkers for disease and treatment response are reviewed. Two key controversies within the area of noninvasive human electrophysiology research are discussed, and problems that currently either function as barriers or provide gateways to progress. First, the differences between the main types of EEG measurements (event-related potentials, quantitative EEG, and time–frequency measures) and how they can contribute collectively to better understanding of cortical dynamics underlying cognition and behavior are highlighted. Second, we focus on the ongoing shift in analytic focus to specific cortical sources and source networks whose dynamics are relevant to the clinical and experimental focus of the study, and the effective increase in source signal-to-noise ratio (SNR) that may be obtained in the process. Conclusions Understanding of these issues informs any discussion of current trends in EEG research. We highlight possible ways to evolve our understanding of brain dynamics beyond the apparent contradictions in understanding and modeling EEG activity highlighted by these controversies. Finally, we summarize some promising future directions of EEG biomarker research in child psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12435 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Research Review: Use of EEG biomarkers in child psychiatry research – current state and future directions [texte imprimé] / Sandra K. LOO, Auteur ; Agatha LENARTOWICZ, Auteur ; Scott MAKEIG, Auteur . - p.4-17. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.4-17 Mots-clés : EEG  event-related potential  brain imaging  neurophysiology  psychopathology Index. décimale : PER Périodiques Résumé : Background Electroencephalography (EEG) and related measures have a long and productive history in child psychopathology research and are currently experiencing a renaissance in interest, particularly for use as putative biomarkers. Method and Scope First, the recent history leading to the use of EEG measures as endophenotypes and biomarkers for disease and treatment response are reviewed. Two key controversies within the area of noninvasive human electrophysiology research are discussed, and problems that currently either function as barriers or provide gateways to progress. First, the differences between the main types of EEG measurements (event-related potentials, quantitative EEG, and time–frequency measures) and how they can contribute collectively to better understanding of cortical dynamics underlying cognition and behavior are highlighted. Second, we focus on the ongoing shift in analytic focus to specific cortical sources and source networks whose dynamics are relevant to the clinical and experimental focus of the study, and the effective increase in source signal-to-noise ratio (SNR) that may be obtained in the process. Conclusions Understanding of these issues informs any discussion of current trends in EEG research. We highlight possible ways to evolve our understanding of brain dynamics beyond the apparent contradictions in understanding and modeling EEG activity highlighted by these controversies. Finally, we summarize some promising future directions of EEG biomarker research in child psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12435 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

---

1 (1 - 2 / 2) Par page : 25 50 100 200