Beware of Over-Interpreting Negative Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 38-9 (October 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1609-1610 Titre : Beware of Over-Interpreting Negative Trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Benedetto VITIELLO, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.1609-1610 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0581-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=604 [article] Beware of Over-Interpreting Negative Trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Benedetto VITIELLO, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.1609-1610. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1609-1610 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0581-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=604

Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746 Titre : Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur Article en page(s) : p.739-746 Langues : Anglais (eng) Mots-clés : Social disability  Autism  Research Units on Pediatric Psychopharmacology (RUPP)  Autism Network  Social withdrawal  Risperidone  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur . - p.739-746. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746 Mots-clés : Social disability  Autism  Research Units on Pediatric Psychopharmacology (RUPP)  Autism Network  Social withdrawal  Risperidone  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

Clinical and Cognitive Correlates of Depressive Symptoms Among Youth with Obsessive Compulsive Disorder / Tara S. PERIS in Journal of Clinical Child & Adolescent Psychology, 39-5 (September-October 2010)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 39-5 (September-October 2010) . - p.616-626 Titre : Clinical and Cognitive Correlates of Depressive Symptoms Among Youth with Obsessive Compulsive Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tara S. PERIS, Auteur ; Joan ASARNOW ROSENBAUM, Auteur ; John PIACENTINI, Auteur ; R. Lindsey BERGMAN, Auteur ; Audra LANGLEY, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2010 Article en page(s) : p.616-626 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Depression is the most common comorbidity among adults with obsessive compulsive disorder (OCD), yet little is known about depressive symptoms in childhood OCD. This study examined clinical and cognitive variables associated with depressive symptomatology in 71 youths (62% male, M age = 12.7 years) with primary OCD. Youths presented with a range of depressive symptoms, with 21% scoring at or above the clinical cutoff on the self-report measure of depression. Higher levels of depressive symptoms were associated with higher levels of cognitive distortions assessed on measures of insight, perceived control, competence, and contingencies. Depressive symptoms were also linked to older age and more severe OCD. Low perceived control and self-competence and high OCD severity independently predicted depression scores. En ligne : http://dx.doi.org/10.1080/15374416.2010.501285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Clinical and Cognitive Correlates of Depressive Symptoms Among Youth with Obsessive Compulsive Disorder [Texte imprimé et/ou numérique] / Tara S. PERIS, Auteur ; Joan ASARNOW ROSENBAUM, Auteur ; John PIACENTINI, Auteur ; R. Lindsey BERGMAN, Auteur ; Audra LANGLEY, Auteur ; James T. MCCRACKEN, Auteur . - 2010 . - p.616-626. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 39-5 (September-October 2010) . - p.616-626 Index. décimale : PER Périodiques Résumé : Depression is the most common comorbidity among adults with obsessive compulsive disorder (OCD), yet little is known about depressive symptoms in childhood OCD. This study examined clinical and cognitive variables associated with depressive symptomatology in 71 youths (62% male, M age = 12.7 years) with primary OCD. Youths presented with a range of depressive symptoms, with 21% scoring at or above the clinical cutoff on the self-report measure of depression. Higher levels of depressive symptoms were associated with higher levels of cognitive distortions assessed on measures of insight, perceived control, competence, and contingencies. Depressive symptoms were also linked to older age and more severe OCD. Low perceived control and self-competence and high OCD severity independently predicted depression scores. En ligne : http://dx.doi.org/10.1080/15374416.2010.501285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Titre : Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes Type de document : Texte imprimé et/ou numérique Auteurs : Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes [Texte imprimé et/ou numérique] / Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Correlates of insight among youth with obsessive-compulsive disorder / Adam B. LEWIN in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.603-611 Titre : Correlates of insight among youth with obsessive-compulsive disorder Type de document : Texte imprimé et/ou numérique Auteurs : Adam B. LEWIN, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur ; R. Lindsey BERGMAN, Auteur ; Susanna CHANG, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2010 Article en page(s) : p.603-611 Langues : Anglais (eng) Mots-clés : OCD obsessive-compulsive-disorder insight child Index. décimale : PER Périodiques Résumé : Background: Individuals with Obsessive-Compulsive Disorder (OCD) may lack insight into the irrational nature of their symptoms. Among adults with OCD, poor insight has been linked to greater symptom severity, increased likelihood of comorbid symptoms, lower adaptive functioning, and worse treatment outcomes. Parallel work regarding insight among children and adolescents, with OCD, is lacking. The aim of this research was to examine links between insight and demographic, cognitive, and clinical factors among youth with OCD. Methods: Seventy-one youths with OCD (mean age = 11.7; 63% = male) were assessed as part of a larger treatment trial. Insight was measured via clinician interview. Results: Youth with low insight had poorer intellectual functioning and reported decreased perception of control over their environment. Additionally, youth with low insight were more likely to be younger, to report higher levels of depressive symptoms, and to report lower levels of adaptive functioning. Conclusion: This set of cognitive, developmental and clinical factors that may predispose youth with OCD to have diminished insight. Data provide initial empirical support for diagnostic differences between youth and adults with regard to requiring intact insight. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02181.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Correlates of insight among youth with obsessive-compulsive disorder [Texte imprimé et/ou numérique] / Adam B. LEWIN, Auteur ; John PIACENTINI, Auteur ; Tara S. PERIS, Auteur ; R. Lindsey BERGMAN, Auteur ; Susanna CHANG, Auteur ; James T. MCCRACKEN, Auteur . - 2010 . - p.603-611. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.603-611 Mots-clés : OCD obsessive-compulsive-disorder insight child Index. décimale : PER Périodiques Résumé : Background: Individuals with Obsessive-Compulsive Disorder (OCD) may lack insight into the irrational nature of their symptoms. Among adults with OCD, poor insight has been linked to greater symptom severity, increased likelihood of comorbid symptoms, lower adaptive functioning, and worse treatment outcomes. Parallel work regarding insight among children and adolescents, with OCD, is lacking. The aim of this research was to examine links between insight and demographic, cognitive, and clinical factors among youth with OCD. Methods: Seventy-one youths with OCD (mean age = 11.7; 63% = male) were assessed as part of a larger treatment trial. Insight was measured via clinician interview. Results: Youth with low insight had poorer intellectual functioning and reported decreased perception of control over their environment. Additionally, youth with low insight were more likely to be younger, to report higher levels of depressive symptoms, and to report lower levels of adaptive functioning. Conclusion: This set of cognitive, developmental and clinical factors that may predispose youth with OCD to have diminished insight. Data provide initial empirical support for diagnostic differences between youth and adults with regard to requiring intact insight. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02181.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

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Development and validation of an item response theory-based Social Responsiveness Scale short form / Alexandra STURM in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

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Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders / Victoria HALLETT in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

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Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders / Roumen N. NIKOLOV in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

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Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder / Lawrence SCAHILL in Autism, 19-1 (January 2015)  

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Parsing heterogeneity in attention?deficit hyperactivity disorder using EEG?based subgroups / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 59-3 (March 2018)  

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Pharmacotherapy for Autism Spectrum Disorders / James T. MCCRACKEN

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Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity / Laudan B. JAHROMI in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study / Craig ERICKSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research / Lindsay M. OBERMAN in Autism Research, 9-2 (February 2016)  

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