Default mode network maturation and psychopathology in children and adolescents / João Ricardo SATO in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Titre : Default mode network maturation and psychopathology in children and adolescents Type de document : Texte imprimé et/ou numérique Auteurs : João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele Gus MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe Almeida PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Amaro JR, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur Article en page(s) : p.55-64 Langues : Anglais (eng) Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] Default mode network maturation and psychopathology in children and adolescents [Texte imprimé et/ou numérique] / João Ricardo SATO, Auteur ; Giovanni A. SALUM, Auteur ; Ary GADELHA, Auteur ; Nicolas CROSSLEY, Auteur ; Gilson VIEIRA, Auteur ; Gisele Gus MANFRO, Auteur ; André ZUGMAN, Auteur ; Felipe Almeida PICON, Auteur ; Pedro M. PAN, Auteur ; Marcelo Queiroz HOEXTER, Auteur ; Mauricio ANÉS, Auteur ; Luciana Monteiro MOURA, Auteur ; Marco Antonio Gomes DEL'AQUILLA, Auteur ; Edson Amaro JR, Auteur ; Philip MCGUIRE, Auteur ; Acioly Luiz Tavares LACERDA, Auteur ; Luis Augusto ROHDE, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Andrea Parolin JACKOWSKI, Auteur ; Rodrigo Affonseca BRESSAN, Auteur . - p.55-64. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.55-64 Mots-clés : Neurodevelopment  default mode network  neuroimaging  psychopathology  MVPA Index. décimale : PER Périodiques Résumé : Background The human default mode (DMN) is involved in a wide array of mental disorders. Current knowledge suggests that mental health disorders may reflect deviant trajectories of brain maturation. Method We studied 654 children using functional magnetic resonance imaging (fMRI) scans under a resting-state protocol. A machine-learning method was used to obtain age predictions of children based on the average coefficient of fractional amplitude of low frequency fluctuations (fALFFs) of the DMN, a measure of spontaneous local activity. The chronological ages of the children and fALFF measures from regions of this network, the response and predictor variables were considered respectively in a Gaussian Process Regression. Subsequently, we computed a network maturation status index for each subject (actual age minus predicted). We then evaluated the association between this maturation index and psychopathology scores on the Child Behavior Checklist (CBCL). Results Our hypothesis was that the maturation status of the DMN would be negatively associated with psychopathology. Consistent with previous studies, fALFF significantly predicted the age of participants (p < .001). Furthermore, as expected, we found an association between the DMN maturation status (precocious vs. delayed) and general psychopathology scores (p = .011). Conclusions Our findings suggest that child psychopathology seems to be associated with delayed maturation of the DMN. This delay in the neurodevelopmental trajectory may offer interesting insights into the pathophysiology of mental health disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12444 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273

Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation / João VILLANOVA DO AMARAL ; Giovanni Abrahão SALUM ; Euripedes Constantino MIGUEL ; Luis Augusto ROHDE ; George B. PLOUBIDIS ; Eoin MCELROY ; Mauricio Scopel HOFFMANN in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.725-736 Titre : Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation Type de document : Texte imprimé et/ou numérique Auteurs : João VILLANOVA DO AMARAL, Auteur ; Giovanni Abrahão SALUM, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Luis Augusto ROHDE, Auteur ; George B. PLOUBIDIS, Auteur ; Eoin MCELROY, Auteur ; Mauricio Scopel HOFFMANN, Auteur Article en page(s) : p.725-736 Langues : Anglais (eng) Mots-clés : Adolescent mental health  social connection  country comparison  harmonisation Index. décimale : PER Périodiques Résumé : Background Social connection factors play a key role for young people's mental health. It is important to understand how their influence may vary across contexts. We investigated structural (e.g. household size), functional (e.g. social support) and quality (e.g. feeling close) social connection factors in relation to adolescent internalising and externalising symptoms, comparing two countries Brazil and the United Kingdom (UK). Methods We pooled data from the UK Millennium Cohort Study (MCS) and the Brazilian High Risk Cohort Study (BHRCS). We included 12 social connection variables, identified through retrospective harmonisation and lived experience expert involvement. We tested measurement invariance and conducted multiple regressions to analyse associations between the social connection factors (age 14) and later internalising and externalising difficulties (age 17.5) in both cohorts. We investigated country-level interactions and used weights to account for attrition, survey design, population representativeness and sample size. Results We found pooled main associations with later internalising symptoms for ?living with half-siblings? (p? En ligne : https://doi.org/10.1111/jcpp.14080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Social connection and its prospective association with adolescent internalising and externalising symptoms: an exploratory cross-country study using retrospective harmonisation [Texte imprimé et/ou numérique] / João VILLANOVA DO AMARAL, Auteur ; Giovanni Abrahão SALUM, Auteur ; Euripedes Constantino MIGUEL, Auteur ; Luis Augusto ROHDE, Auteur ; George B. PLOUBIDIS, Auteur ; Eoin MCELROY, Auteur ; Mauricio Scopel HOFFMANN, Auteur . - p.725-736. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.725-736 Mots-clés : Adolescent mental health  social connection  country comparison  harmonisation Index. décimale : PER Périodiques Résumé : Background Social connection factors play a key role for young people's mental health. It is important to understand how their influence may vary across contexts. We investigated structural (e.g. household size), functional (e.g. social support) and quality (e.g. feeling close) social connection factors in relation to adolescent internalising and externalising symptoms, comparing two countries Brazil and the United Kingdom (UK). Methods We pooled data from the UK Millennium Cohort Study (MCS) and the Brazilian High Risk Cohort Study (BHRCS). We included 12 social connection variables, identified through retrospective harmonisation and lived experience expert involvement. We tested measurement invariance and conducted multiple regressions to analyse associations between the social connection factors (age 14) and later internalising and externalising difficulties (age 17.5) in both cohorts. We investigated country-level interactions and used weights to account for attrition, survey design, population representativeness and sample size. Results We found pooled main associations with later internalising symptoms for ?living with half-siblings? (p? En ligne : https://doi.org/10.1111/jcpp.14080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

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