82 recherche sur le mot-clé 'Neurodevelopment'

Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment / Yihui ZHU in Autism Research, 14-1 (January 2021)  

Public ISBD [article]  inAutism Research > 14-1 (January 2021) . - p.11-28 Titre : Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment Type de document : texte imprimé Auteurs : Yihui ZHU, Auteur ; Charles E. MORDAUNT, Auteur ; Blythe DURBIN-JOHNSON, Auteur ; Marie A. CAUDILL, Auteur ; Olga V. MALYSHEVA, Auteur ; Joshua W. MILLER, Auteur ; Ralph GREEN, Auteur ; S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Janine M. LASALLE, Auteur Article en page(s) : p.11-28 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  maternal blood  neurodevelopment  nutrition  one-carbon metabolites  prenatal  transcriptome Index. décimale : PER Périodiques Résumé : The prenatal period is a critical window for the development of autism spectrum disorder (ASD). The relationship between prenatal nutrients and gestational gene expression in mothers of children later diagnosed with ASD or non-typical development (Non-TD) is poorly understood. Maternal blood collected prospectively during pregnancy provides insights into the effects of nutrition, particularly one-carbon metabolites, on gene pathways and neurodevelopment. Genome-wide transcriptomes were measured with microarrays in 300 maternal blood samples in Markers of Autism Risk in Babies-Learning Early Signs. Sixteen different one-carbon metabolites, including folic acid, betaine, 5'-methyltretrahydrofolate (5-MeTHF), and dimethylglycine (DMG) were measured. Differential expression analysis and weighted gene correlation network analysis (WGCNA) were used to compare gene expression between children later diagnosed as typical development (TD), Non-TD and ASD, and to one-carbon metabolites. Using differential gene expression analysis, six transcripts (TGR-AS1, SQSTM1, HLA-C, and RFESD) were associated with child outcomes (ASD, Non-TD, and TD) with genome-wide significance. Genes nominally differentially expressed between ASD and TD significantly overlapped with seven high confidence ASD genes. WGCNA identified co-expressed gene modules significantly correlated with 5-MeTHF, folic acid, DMG, and betaine. A module enriched in DNA methylation functions showed a suggestive protective association with folic acid/5-MeTHF concentrations and ASD risk. Maternal plasma betaine and DMG concentrations were associated with a block of co-expressed genes enriched for adaptive immune, histone modification, and RNA processing functions. These results suggest that the prenatal maternal blood transcriptome is a sensitive indicator of gestational one-carbon metabolite status and changes relevant to children's later neurodevelopmental outcomes. LAY SUMMARY: Pregnancy is a time when maternal nutrition could interact with genetic risk for autism spectrum disorder. Blood samples collected during pregnancy from mothers who had a prior child with autism were examined for gene expression and nutrient metabolites, then compared to the diagnosis of the child at age three. Expression differences in gene pathways related to the immune system and gene regulation were observed for pregnancies of children with autism and non-typical neurodevelopment and were associated with maternal nutrients. En ligne : http://dx.doi.org/10.1002/aur.2428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment [texte imprimé] / Yihui ZHU, Auteur ; Charles E. MORDAUNT, Auteur ; Blythe DURBIN-JOHNSON, Auteur ; Marie A. CAUDILL, Auteur ; Olga V. MALYSHEVA, Auteur ; Joshua W. MILLER, Auteur ; Ralph GREEN, Auteur ; S. Jill JAMES, Auteur ; Stepan MELNYK, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Janine M. LASALLE, Auteur . - p.11-28. Langues : Anglais (eng) in Autism Research > 14-1 (January 2021) . - p.11-28 Mots-clés : autism spectrum disorder  maternal blood  neurodevelopment  nutrition  one-carbon metabolites  prenatal  transcriptome Index. décimale : PER Périodiques Résumé : The prenatal period is a critical window for the development of autism spectrum disorder (ASD). The relationship between prenatal nutrients and gestational gene expression in mothers of children later diagnosed with ASD or non-typical development (Non-TD) is poorly understood. Maternal blood collected prospectively during pregnancy provides insights into the effects of nutrition, particularly one-carbon metabolites, on gene pathways and neurodevelopment. Genome-wide transcriptomes were measured with microarrays in 300 maternal blood samples in Markers of Autism Risk in Babies-Learning Early Signs. Sixteen different one-carbon metabolites, including folic acid, betaine, 5'-methyltretrahydrofolate (5-MeTHF), and dimethylglycine (DMG) were measured. Differential expression analysis and weighted gene correlation network analysis (WGCNA) were used to compare gene expression between children later diagnosed as typical development (TD), Non-TD and ASD, and to one-carbon metabolites. Using differential gene expression analysis, six transcripts (TGR-AS1, SQSTM1, HLA-C, and RFESD) were associated with child outcomes (ASD, Non-TD, and TD) with genome-wide significance. Genes nominally differentially expressed between ASD and TD significantly overlapped with seven high confidence ASD genes. WGCNA identified co-expressed gene modules significantly correlated with 5-MeTHF, folic acid, DMG, and betaine. A module enriched in DNA methylation functions showed a suggestive protective association with folic acid/5-MeTHF concentrations and ASD risk. Maternal plasma betaine and DMG concentrations were associated with a block of co-expressed genes enriched for adaptive immune, histone modification, and RNA processing functions. These results suggest that the prenatal maternal blood transcriptome is a sensitive indicator of gestational one-carbon metabolite status and changes relevant to children's later neurodevelopmental outcomes. LAY SUMMARY: Pregnancy is a time when maternal nutrition could interact with genetic risk for autism spectrum disorder. Blood samples collected during pregnancy from mothers who had a prior child with autism were examined for gene expression and nutrient metabolites, then compared to the diagnosis of the child at age three. Expression differences in gene pathways related to the immune system and gene regulation were observed for pregnancies of children with autism and non-typical neurodevelopment and were associated with maternal nutrients. En ligne : http://dx.doi.org/10.1002/aur.2428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Perinatal hardship and infant neurodevelopment: insights from a global pandemic / Jonathan POSNER in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.755-765 Titre : Perinatal hardship and infant neurodevelopment: insights from a global pandemic Type de document : texte imprimé Auteurs : Jonathan POSNER, Auteur ; Andrew MICHAEL, Auteur ; Pratik KASHYAP, Auteur ; Meredith FAY, Auteur ; Ana Carolina Coelho MILANI, Auteur ; Ivaldo SILVA, Auteur ; Nitamar ABDALA, Auteur ; Célia Maria DE ARAÚJO, Auteur ; Aline Camargo RAMOS, Auteur ; Yun WANG, Auteur ; Mateus MAZZAFERRO, Auteur ; Andrea JACKOWSKI, Auteur ; Cristiane S. DUARTE, Auteur Article en page(s) : p.755-765 Langues : Anglais (eng) Mots-clés : Neurodevelopment  perinatal hardship  hippocampus  COVID-19  infant MRI  socioeconomic adversity Index. décimale : PER Périodiques Résumé : Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID-19 pandemic as a natural context in which such hardships were widespread, particularly in low-resource settings. Methods This cohort study examined associations between pandemic-related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother?infant dyads from low-resource healthcare settings in Brazil were enrolled during the COVID-19 pandemic. Maternal hardships were assessed using a COVID-19-specific questionnaire, which included self-reported COVID-19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2?6?weeks of age and behavioral assessments at 14?months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left (pfdr?=?.008) and right (pfdr?=?.025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex (p?=?.004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14?months (r?=?.23; p?=?.02). Maternal emotional distress and self-reported COVID-19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. En ligne : https://doi.org/10.1111/jcpp.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Perinatal hardship and infant neurodevelopment: insights from a global pandemic [texte imprimé] / Jonathan POSNER, Auteur ; Andrew MICHAEL, Auteur ; Pratik KASHYAP, Auteur ; Meredith FAY, Auteur ; Ana Carolina Coelho MILANI, Auteur ; Ivaldo SILVA, Auteur ; Nitamar ABDALA, Auteur ; Célia Maria DE ARAÚJO, Auteur ; Aline Camargo RAMOS, Auteur ; Yun WANG, Auteur ; Mateus MAZZAFERRO, Auteur ; Andrea JACKOWSKI, Auteur ; Cristiane S. DUARTE, Auteur . - p.755-765. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.755-765 Mots-clés : Neurodevelopment  perinatal hardship  hippocampus  COVID-19  infant MRI  socioeconomic adversity Index. décimale : PER Périodiques Résumé : Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID-19 pandemic as a natural context in which such hardships were widespread, particularly in low-resource settings. Methods This cohort study examined associations between pandemic-related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother?infant dyads from low-resource healthcare settings in Brazil were enrolled during the COVID-19 pandemic. Maternal hardships were assessed using a COVID-19-specific questionnaire, which included self-reported COVID-19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2?6?weeks of age and behavioral assessments at 14?months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left (pfdr?=?.008) and right (pfdr?=?.025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex (p?=?.004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14?months (r?=?.23; p?=?.02). Maternal emotional distress and self-reported COVID-19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. En ligne : https://doi.org/10.1111/jcpp.70060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Neurodevelopmental delays in children born after medically assisted reproduction: a national population cohort study / Seung-Ah CHOE in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Neurodevelopmental delays in children born after medically assisted reproduction: a national population cohort study Type de document : texte imprimé Auteurs : Seung-Ah CHOE, Auteur ; Eunseon GWAK, Auteur ; Juyoung LEE, Auteur ; Jung Hye BYEON, Auteur ; Ju-Young SHIN, Auteur ; Seungbong HAN, Auteur ; Jee Hyun KIM, Auteur Langues : Anglais (eng) Mots-clés : Humans  Female  Adult  Retrospective Studies  Republic of Korea/epidemiology  Fertilization in Vitro/statistics & numerical data/adverse effects  Neurodevelopmental Disorders/epidemiology/etiology  Male  Young Adult  Incidence  Child, Preschool  Reproductive Techniques, Assisted/statistics & numerical data/adverse effects  Infertility, Female/therapy/epidemiology  Middle Aged  Cohort Studies  Infant, Newborn  Developmental Disabilities/epidemiology  Child  Assisted reproduction  Developmental screening test  Neurodevelopment  was anonymous, the protocol of this study was reviewed and exempted from ethical  approval (exemption No. KUIRB-2024-0053-01). Consent to participate was not  applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Importance: The neurodevelopmental outcomes of children born after medically assisted reproduction remain incompletely characterized on a population level. We were to assess the incidence and relative risk of neurodevelopmental delay in the children of infertile women born after unassisted conception, intrauterine insemination (IUI), and in vitro fertilization (IVF). METHOD: We conducted a retrospective cohort study using the National Health Insurance Service database of South Korea from October 2017 through December 2023. The study included 115 839 singleton, full-term, non-low-birthweight children born to women aged 20-49 years with a diagnosis of female infertility. The exposure was mode of conception-spontaneous, IUI, or IVF-balanced by propensity score matching on preconceptional maternal factors. Outcome measure was neurodevelopmental delay, defined as scoring below the cutoff in any of six functional domains on the Korean Developmental Screening Test across six consecutive rounds. Crude incidence rate ratios (IRRs) and adjusted hazard ratios (aHRs) were estimated using Cox proportional hazards models. RESULTS: Among 115 839 children, 6 575 (5.7%) exhibited delay in at least one domain. Crude IRRs for any delay were 1.19 (95% confidence interval [CI]: 1.07, 1.61) for IUI and 1.10 (95% CI: 1.03, 1.17) for IVF versus unassisted conception. In the survival models, higher risks persisted for both IUI (aHR = 1.19; 95% CI: 1.06, 1.34) and IVF (1.09, 95% CI: 1.02, 1.06) compared with unassisted conception. When comparing IVF and IUI, IVF conferred a lower risk of fine motor delay than IUI (0.84, 95% CI: 0.72, 0.99). Among IVF births, risk of developmental delay was similar across all six domains for frozen and fresh embryo transfers. CONCLUSIONS: Children conceived via IUI or IVF demonstrated a modest but significant increase in screen-positive neurodevelopmental delay compared with those conceived spontaneously. These findings highlight the need for neurodevelopmental monitoring in this population. En ligne : https://dx.doi.org/10.1186/s11689-025-09658-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Neurodevelopmental delays in children born after medically assisted reproduction: a national population cohort study [texte imprimé] / Seung-Ah CHOE, Auteur ; Eunseon GWAK, Auteur ; Juyoung LEE, Auteur ; Jung Hye BYEON, Auteur ; Ju-Young SHIN, Auteur ; Seungbong HAN, Auteur ; Jee Hyun KIM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Female  Adult  Retrospective Studies  Republic of Korea/epidemiology  Fertilization in Vitro/statistics & numerical data/adverse effects  Neurodevelopmental Disorders/epidemiology/etiology  Male  Young Adult  Incidence  Child, Preschool  Reproductive Techniques, Assisted/statistics & numerical data/adverse effects  Infertility, Female/therapy/epidemiology  Middle Aged  Cohort Studies  Infant, Newborn  Developmental Disabilities/epidemiology  Child  Assisted reproduction  Developmental screening test  Neurodevelopment  was anonymous, the protocol of this study was reviewed and exempted from ethical  approval (exemption No. KUIRB-2024-0053-01). Consent to participate was not  applicable. Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Importance: The neurodevelopmental outcomes of children born after medically assisted reproduction remain incompletely characterized on a population level. We were to assess the incidence and relative risk of neurodevelopmental delay in the children of infertile women born after unassisted conception, intrauterine insemination (IUI), and in vitro fertilization (IVF). METHOD: We conducted a retrospective cohort study using the National Health Insurance Service database of South Korea from October 2017 through December 2023. The study included 115 839 singleton, full-term, non-low-birthweight children born to women aged 20-49 years with a diagnosis of female infertility. The exposure was mode of conception-spontaneous, IUI, or IVF-balanced by propensity score matching on preconceptional maternal factors. Outcome measure was neurodevelopmental delay, defined as scoring below the cutoff in any of six functional domains on the Korean Developmental Screening Test across six consecutive rounds. Crude incidence rate ratios (IRRs) and adjusted hazard ratios (aHRs) were estimated using Cox proportional hazards models. RESULTS: Among 115 839 children, 6 575 (5.7%) exhibited delay in at least one domain. Crude IRRs for any delay were 1.19 (95% confidence interval [CI]: 1.07, 1.61) for IUI and 1.10 (95% CI: 1.03, 1.17) for IVF versus unassisted conception. In the survival models, higher risks persisted for both IUI (aHR = 1.19; 95% CI: 1.06, 1.34) and IVF (1.09, 95% CI: 1.02, 1.06) compared with unassisted conception. When comparing IVF and IUI, IVF conferred a lower risk of fine motor delay than IUI (0.84, 95% CI: 0.72, 0.99). Among IVF births, risk of developmental delay was similar across all six domains for frozen and fresh embryo transfers. CONCLUSIONS: Children conceived via IUI or IVF demonstrated a modest but significant increase in screen-positive neurodevelopmental delay compared with those conceived spontaneously. These findings highlight the need for neurodevelopmental monitoring in this population. En ligne : https://dx.doi.org/10.1186/s11689-025-09658-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies / Meghan R. SWANSON in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 33 Titre : White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies Type de document : texte imprimé Auteurs : Meghan R. SWANSON, Auteur ; Heather C. HAZLETT, Auteur Article en page(s) : 33 Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder/diagnostic imaging/pathology/therapy  Biomarkers  Brain/diagnostic imaging/growth & development/pathology  Early Medical Intervention  Fragile X Syndrome/diagnostic imaging/pathology/therapy  Humans  Neurodevelopmental Disorders/diagnostic imaging/pathology/therapy  White Matter/diagnostic imaging/growth & development/pathology  Autism spectrum disorder  Brain  Clinical trial  Fragile X syndrome  Intervention  Myelin  Neurodevelopment  Treatment  White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Early intervention is a valuable tool to support the development of toddlers with neurodevelopmental disorders. With recent research advances in early identification that allow for pre-symptomatic detection of autism in infancy, scientists are looking forward to intervention during infancy. These advances may be supported by the identification of biologically based treatment and outcome measures that are sensitive and dimensional. The purpose of this review is to evaluate white matter neurodevelopment as a monitoring biomarker for early treatment of neurodevelopmental disorders. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) as used as exemplars. White matter has unique neurobiology, including a prolonged period of dynamic development. This developmental pattern may make white matter especially responsive to treatment. White matter develops aberrantly in children with ASD and FXS. Histologic studies in rodents have provided targets for FXS pharmacological intervention. However, pharmaceutical clinical trials in humans failed to garner positive clinical results. In this article, we argue that the use of neurobiological monitoring biomarkers may overcome some of these limitations, as they are objective, not susceptible to placebo effects, and are dimensional in nature. SHORT CONCLUSION: As the field moves towards earlier detection and early intervention for neurodevelopmental disorders, we encourage scientists to consider the advantages of using neurobiological features as monitoring biomarkers. En ligne : https://dx.doi.org/10.1186/s11689-019-9295-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies [texte imprimé] / Meghan R. SWANSON, Auteur ; Heather C. HAZLETT, Auteur . - 33. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 33 Mots-clés : Animals  Autism Spectrum Disorder/diagnostic imaging/pathology/therapy  Biomarkers  Brain/diagnostic imaging/growth & development/pathology  Early Medical Intervention  Fragile X Syndrome/diagnostic imaging/pathology/therapy  Humans  Neurodevelopmental Disorders/diagnostic imaging/pathology/therapy  White Matter/diagnostic imaging/growth & development/pathology  Autism spectrum disorder  Brain  Clinical trial  Fragile X syndrome  Intervention  Myelin  Neurodevelopment  Treatment  White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Early intervention is a valuable tool to support the development of toddlers with neurodevelopmental disorders. With recent research advances in early identification that allow for pre-symptomatic detection of autism in infancy, scientists are looking forward to intervention during infancy. These advances may be supported by the identification of biologically based treatment and outcome measures that are sensitive and dimensional. The purpose of this review is to evaluate white matter neurodevelopment as a monitoring biomarker for early treatment of neurodevelopmental disorders. Fragile X syndrome (FXS) and autism spectrum disorder (ASD) as used as exemplars. White matter has unique neurobiology, including a prolonged period of dynamic development. This developmental pattern may make white matter especially responsive to treatment. White matter develops aberrantly in children with ASD and FXS. Histologic studies in rodents have provided targets for FXS pharmacological intervention. However, pharmaceutical clinical trials in humans failed to garner positive clinical results. In this article, we argue that the use of neurobiological monitoring biomarkers may overcome some of these limitations, as they are objective, not susceptible to placebo effects, and are dimensional in nature. SHORT CONCLUSION: As the field moves towards earlier detection and early intervention for neurodevelopmental disorders, we encourage scientists to consider the advantages of using neurobiological features as monitoring biomarkers. En ligne : https://dx.doi.org/10.1186/s11689-019-9295-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Caregiver-identified strengths in children attending their first neurodevelopmental assessment: Findings from the Sydney child development research registry and development of a child strengths checklist / Lorna HANKIN ; Marie-Antoinette HODGE ; Natalie ONG ; Natalie SILOVE ; Adam J. GUASTELLA in Autism, 29-7 (July 2025)  

Public ISBD [article]  inAutism > 29-7 (July 2025) . - p.1769-1781 Titre : Caregiver-identified strengths in children attending their first neurodevelopmental assessment: Findings from the Sydney child development research registry and development of a child strengths checklist Type de document : texte imprimé Auteurs : Lorna HANKIN, Auteur ; Marie-Antoinette HODGE, Auteur ; Natalie ONG, Auteur ; Natalie SILOVE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.1769-1781 Langues : Anglais (eng) Mots-clés : assessment  autism spectrum disorders  neurodevelopment  ADHD  communication disorders  strengths Index. décimale : PER Périodiques Résumé : There has been a growing focus on the importance of understanding strengths in children with neurodevelopmental conditions and how such knowledge can support clinical practices. However, limited research has explored systematic reports of strengths from caregivers of children with neurodevelopmental conditions, most commonly autism. In this study, we explored caregiver-identified strengths in children attending their first neurodevelopmental assessment. Caregivers of 686 children attending a tertiary assessment service answered a survey question about their children s strengths. Content analysis identified 61 unique categories of strengths, which were grouped into six themes: cognitive and intellectual, social and interpersonal, hobbies and passions, character and personality, physical, and behavioural. The most frequently reported specific strengths were kind caring, and compassionate, social and friendly, loving and affectionate, music singing and dancing, and good memory recall. The breadth of positive strengths identified here may reflect the larger population sampled or the diversity of presentations in this cohort. We then present a caregiver checklist, the Child Autism and Neurodevelopment Strengths (CANS) Checklist, that was developed with community representatives, to inform assessment and feedback of child strengths. We discuss what is required to use this knowledge to inform strengths-based practices that can support clinical practice and inform on child development and family well-being.Lay Abstract There has been a growing focus on the importance of understanding strengths in children with neurodevelopmental conditions, but there is little research exploring caregiver-reported strengths at the time of diagnostic assessment. In this study, we explored caregiver-identified strengths in 686 children who were attending a neurodevelopmental assessment. Content analysis identified 61 unique categories of strengths, which we grouped into six main themes. These six themes were cognitive and intellectual, social and interpersonal, hobbies and passions, character and personality, physical, and behavioural. The most common strengths identified by caregivers were 'kind, caring, and compassionate", 'social and friendly", 'loving and affectionate", 'music, singing, and dancing", and 'good memory recall". Based on these strengths, we present a checklist that was developed with community representatives, to make sure a strengths-based framework can be used during the diagnostic process. We discuss how we can use this knowledge to develop strengths-based practices that can support clinical practice and inform on child development and family well-being. En ligne : https://dx.doi.org/10.1177/13623613251325287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Caregiver-identified strengths in children attending their first neurodevelopmental assessment: Findings from the Sydney child development research registry and development of a child strengths checklist [texte imprimé] / Lorna HANKIN, Auteur ; Marie-Antoinette HODGE, Auteur ; Natalie ONG, Auteur ; Natalie SILOVE, Auteur ; Adam J. GUASTELLA, Auteur . - p.1769-1781. Langues : Anglais (eng) in Autism > 29-7 (July 2025) . - p.1769-1781 Mots-clés : assessment  autism spectrum disorders  neurodevelopment  ADHD  communication disorders  strengths Index. décimale : PER Périodiques Résumé : There has been a growing focus on the importance of understanding strengths in children with neurodevelopmental conditions and how such knowledge can support clinical practices. However, limited research has explored systematic reports of strengths from caregivers of children with neurodevelopmental conditions, most commonly autism. In this study, we explored caregiver-identified strengths in children attending their first neurodevelopmental assessment. Caregivers of 686 children attending a tertiary assessment service answered a survey question about their children s strengths. Content analysis identified 61 unique categories of strengths, which were grouped into six themes: cognitive and intellectual, social and interpersonal, hobbies and passions, character and personality, physical, and behavioural. The most frequently reported specific strengths were kind caring, and compassionate, social and friendly, loving and affectionate, music singing and dancing, and good memory recall. The breadth of positive strengths identified here may reflect the larger population sampled or the diversity of presentations in this cohort. We then present a caregiver checklist, the Child Autism and Neurodevelopment Strengths (CANS) Checklist, that was developed with community representatives, to inform assessment and feedback of child strengths. We discuss what is required to use this knowledge to inform strengths-based practices that can support clinical practice and inform on child development and family well-being.Lay Abstract There has been a growing focus on the importance of understanding strengths in children with neurodevelopmental conditions, but there is little research exploring caregiver-reported strengths at the time of diagnostic assessment. In this study, we explored caregiver-identified strengths in 686 children who were attending a neurodevelopmental assessment. Content analysis identified 61 unique categories of strengths, which we grouped into six main themes. These six themes were cognitive and intellectual, social and interpersonal, hobbies and passions, character and personality, physical, and behavioural. The most common strengths identified by caregivers were 'kind, caring, and compassionate", 'social and friendly", 'loving and affectionate", 'music, singing, and dancing", and 'good memory recall". Based on these strengths, we present a checklist that was developed with community representatives, to make sure a strengths-based framework can be used during the diagnostic process. We discuss how we can use this knowledge to develop strengths-based practices that can support clinical practice and inform on child development and family well-being. En ligne : https://dx.doi.org/10.1177/13623613251325287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Congenital muscular torticollis as a potential neonatal marker of autism spectrum disorder and other neurodevelopmental conditions / Michael DAVIDOVITCH in Research in Autism, 132 (April 2026)  

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Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery / Rowena NG in Journal of Neurodevelopmental Disorders, 15 (2023)  

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Ethical dimensions of translational developmental neuroscience research in autism / Arianna MANZINI in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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A Familial Heterozygous Null Mutation of MET in Autism Spectrum Disorder / Nelle LAMBERT in Autism Research, 7-5 (October 2014)  

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Maternal sleep disturbance during pregnancy and child intelligence quotient: A metabolome-wide association study in the Shanghai Birth Cohort / Yun HUANG in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

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