Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents / Oksana Yu NAUMOVA in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.143-155 Titre : Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents Type de document : Texte imprimé et/ou numérique Auteurs : Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur Année de publication : 2012 Article en page(s) : p.143-155 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents [Texte imprimé et/ou numérique] / Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.143-155. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.143-155 Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension / Elena L. GRIGORENKO in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.1089-1103 Titre : Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension Type de document : Texte imprimé et/ou numérique Auteurs : Elena L. GRIGORENKO, Auteur ; Vladislav V. RUCHKIN, Auteur ; Andrew J. PAKSTIS, Auteur ; Lars ORELAND, Auteur ; Roman A. KOPOSOV, Auteur ; Britt A.F. KLINTEBERG, Auteur ; Gerald J. HAEFFEL, Auteur ; Marya GETCHELL, Auteur ; Colin G. DEYOUNG, Auteur ; Carolyn M. YRIGOLLEN, Auteur Année de publication : 2007 Article en page(s) : p.1089-1103 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It is established that reading and reading-related processes are heritable; genes thus play an important role in the foundation of individual differences in reading. In this article, we focus on one facet of reading–comprehension. Comprehension is a higher order cognitive skill that requires many other cognitive processes for it to unfold completely and successfully. One such process is executive functioning, which has been associated with genetic variation in the catechol-O-methyltransferase (COMT) gene. Genotypes and haplotypes of four single nucleotide polymorphisms in COMT were investigated in 179 incarcerated adolescent delinquents. Four hierarchical logistic regression models predicting the presence/absence of comprehension difficulties were fitted to the data; genetic variation in COMT and the presence/absence of maternal rejection were investigated as main effects and as effects acting interactively. Three out of four interaction terms were found to be important predictors of individual differences in comprehension. These findings were supported by the results of the haplotype analyses, in which the four investigated polymorphisms were considered simultaneously. En ligne : http://dx.doi.org/10.1017/s0954579407000557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension [Texte imprimé et/ou numérique] / Elena L. GRIGORENKO, Auteur ; Vladislav V. RUCHKIN, Auteur ; Andrew J. PAKSTIS, Auteur ; Lars ORELAND, Auteur ; Roman A. KOPOSOV, Auteur ; Britt A.F. KLINTEBERG, Auteur ; Gerald J. HAEFFEL, Auteur ; Marya GETCHELL, Auteur ; Colin G. DEYOUNG, Auteur ; Carolyn M. YRIGOLLEN, Auteur . - 2007 . - p.1089-1103. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.1089-1103 Index. décimale : PER Périodiques Résumé : It is established that reading and reading-related processes are heritable; genes thus play an important role in the foundation of individual differences in reading. In this article, we focus on one facet of reading–comprehension. Comprehension is a higher order cognitive skill that requires many other cognitive processes for it to unfold completely and successfully. One such process is executive functioning, which has been associated with genetic variation in the catechol-O-methyltransferase (COMT) gene. Genotypes and haplotypes of four single nucleotide polymorphisms in COMT were investigated in 179 incarcerated adolescent delinquents. Four hierarchical logistic regression models predicting the presence/absence of comprehension difficulties were fitted to the data; genetic variation in COMT and the presence/absence of maternal rejection were investigated as main effects and as effects acting interactively. Three out of four interaction terms were found to be important predictors of individual differences in comprehension. These findings were supported by the results of the haplotype analyses, in which the four investigated polymorphisms were considered simultaneously. En ligne : http://dx.doi.org/10.1017/s0954579407000557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

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