Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits / Li-Feng JIANG-XIE in Molecular Autism, (May 2014)  

Public ISBD [article]  inMolecular Autism > (May 2014) . - p.1-13 Titre : Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits Type de document : Texte imprimé et/ou numérique Auteurs : Li-Feng JIANG-XIE, Auteur ; Hsiao-Mei LIAO, Auteur ; Chia-Hsiang CHEN, Auteur ; Yuh-Tarng CHEN, Auteur ; Shih-Yin HO, Auteur ; Dai-Hua LU, Auteur ; Li-Jen LEE, Auteur ; Horng-Huei LIOU, Auteur ; Wen-Mei FU, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic density (PSD), has been addressed as a candidate gene in autism spectrum disorders. To elucidate the disturbance of synaptic balance arising from Dlgap2 loss-of-function in vivo, we thus generated Dlgap2 ?/? mice to investigate their phenotypes of synaptic function and social behaviors. En ligne : http://dx.doi.org/10.1186/2040-2392-5-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits [Texte imprimé et/ou numérique] / Li-Feng JIANG-XIE, Auteur ; Hsiao-Mei LIAO, Auteur ; Chia-Hsiang CHEN, Auteur ; Yuh-Tarng CHEN, Auteur ; Shih-Yin HO, Auteur ; Dai-Hua LU, Auteur ; Li-Jen LEE, Auteur ; Horng-Huei LIOU, Auteur ; Wen-Mei FU, Auteur ; Susan Shur-Fen GAU, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (May 2014) . - p.1-13 Index. décimale : PER Périodiques Résumé : As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic density (PSD), has been addressed as a candidate gene in autism spectrum disorders. To elucidate the disturbance of synaptic balance arising from Dlgap2 loss-of-function in vivo, we thus generated Dlgap2 ?/? mice to investigate their phenotypes of synaptic function and social behaviors. En ligne : http://dx.doi.org/10.1186/2040-2392-5-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

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