Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures / Daria PRILUTSKY in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-14 Titre : Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures Type de document : Texte imprimé et/ou numérique Auteurs : Daria PRILUTSKY, Auteur ; Alvin T. KHO, Auteur ; Nathan P. PALMER, Auteur ; Asha L. BHAKAR, Auteur ; Niklas SMEDEMARK-MARGULIES, Auteur ; Sek Won KONG, Auteur ; David M. MARGULIES, Auteur ; Mark F. BEAR, Auteur ; Isaac S. KOHANE, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical approaches have demonstrated considerable variability. Here, we study transcriptomes obtained in situ in the intact brain tissues of a murine model of FXS to see how they reflect the in vitro state. En ligne : http://dx.doi.org/10.1186/s13229-015-0061-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures [Texte imprimé et/ou numérique] / Daria PRILUTSKY, Auteur ; Alvin T. KHO, Auteur ; Nathan P. PALMER, Auteur ; Asha L. BHAKAR, Auteur ; Niklas SMEDEMARK-MARGULIES, Auteur ; Sek Won KONG, Auteur ; David M. MARGULIES, Auteur ; Mark F. BEAR, Auteur ; Isaac S. KOHANE, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical approaches have demonstrated considerable variability. Here, we study transcriptomes obtained in situ in the intact brain tissues of a murine model of FXS to see how they reflect the in vitro state. En ligne : http://dx.doi.org/10.1186/s13229-015-0061-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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