Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review / Seema JAIN in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1344-1353 Titre : Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review Type de document : Texte imprimé et/ou numérique Auteurs : Seema JAIN, Auteur ; Rebecca R. ANDRIDGE, Auteur ; Jessica A. HELLINGS, Auteur Article en page(s) : p.1344-1353 Langues : Anglais (eng) Mots-clés : Loxapine  Metabolic side effects  Autism spectrum disorder  Atypical antipsychotics Index. décimale : PER Périodiques Résumé : Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was ?5.7 kg, mean BMI reduction was ?1.9, and mean triglyceride reduction was ?33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability. En ligne : http://dx.doi.org/10.1007/s10803-015-2675-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 [article] Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review [Texte imprimé et/ou numérique] / Seema JAIN, Auteur ; Rebecca R. ANDRIDGE, Auteur ; Jessica A. HELLINGS, Auteur . - p.1344-1353. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1344-1353 Mots-clés : Loxapine  Metabolic side effects  Autism spectrum disorder  Atypical antipsychotics Index. décimale : PER Périodiques Résumé : Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was ?5.7 kg, mean BMI reduction was ?1.9, and mean triglyceride reduction was ?33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability. En ligne : http://dx.doi.org/10.1007/s10803-015-2675-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284

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