Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study / Eugenia CONTI in Autism Research, 9-3 (March 2016)  

Public ISBD [article]  inAutism Research > 9-3 (March 2016) . - p.382-392 Titre : Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study Type de document : Texte imprimé et/ou numérique Auteurs : Eugenia CONTI, Auteur ; Sara CALDERONI, Auteur ; Anna GAGLIANESE, Auteur ; Kerstin PANNEK, Auteur ; Sara MAZZOTTI, Auteur ; Stephen ROSE, Auteur ; Danilo SCELFO, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Giovanni CIONI, Auteur ; Andrea GUZZETTA, Auteur Article en page(s) : p.382-392 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorder  diffusion imaging  high-angular-resolution diffusion imaging  whole brain tractography  toddlers  brain lateralization  cerebral lateralization Index. décimale : PER Périodiques Résumé : Recent diffusion tensor imaging studies in adolescents and children with Autism Spectrum Disorder (ASD) have reported a loss or an inversion of the typical left–right lateralization in fronto-temporal regions crucial for sociocommunicative skills. No studies explored atypical lateralization in toddlers and its correlation with clinical severity of ASD. We recruited a cohort of 20 subjects aged 36 months or younger receiving a first clinical diagnosis of ASD (15 males; age range 20–36 months). Patients underwent diffusion MRI (High-Angular-Resolution Diffusion Imaging protocol). Data from cortical parcellation were combined with tractography to obtain a connection matrix and diffusion indexes (DI) including mean fractional anisotropy (DFA), number of tracts (DNUM), and total tract length (DTTL). A laterality index was generated for each measure, and then correlated with the Autism Diagnostic Observation Schedule-Generic (ADOS-G) total score. Laterality indexes of DFA were significantly correlated with ADOS-G total scores only in two intrafrontal connected areas (correlation was positive in one case and negative in the other). Laterality indexes of DTTL and DNUM showed significant negative correlations (P? En ligne : http://dx.doi.org/10.1002/aur.1533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study [Texte imprimé et/ou numérique] / Eugenia CONTI, Auteur ; Sara CALDERONI, Auteur ; Anna GAGLIANESE, Auteur ; Kerstin PANNEK, Auteur ; Sara MAZZOTTI, Auteur ; Stephen ROSE, Auteur ; Danilo SCELFO, Auteur ; Michela TOSETTI, Auteur ; Filippo MURATORI, Auteur ; Giovanni CIONI, Auteur ; Andrea GUZZETTA, Auteur . - p.382-392. Langues : Anglais (eng) in Autism Research > 9-3 (March 2016) . - p.382-392 Mots-clés : autism  autism spectrum disorder  diffusion imaging  high-angular-resolution diffusion imaging  whole brain tractography  toddlers  brain lateralization  cerebral lateralization Index. décimale : PER Périodiques Résumé : Recent diffusion tensor imaging studies in adolescents and children with Autism Spectrum Disorder (ASD) have reported a loss or an inversion of the typical left–right lateralization in fronto-temporal regions crucial for sociocommunicative skills. No studies explored atypical lateralization in toddlers and its correlation with clinical severity of ASD. We recruited a cohort of 20 subjects aged 36 months or younger receiving a first clinical diagnosis of ASD (15 males; age range 20–36 months). Patients underwent diffusion MRI (High-Angular-Resolution Diffusion Imaging protocol). Data from cortical parcellation were combined with tractography to obtain a connection matrix and diffusion indexes (DI) including mean fractional anisotropy (DFA), number of tracts (DNUM), and total tract length (DTTL). A laterality index was generated for each measure, and then correlated with the Autism Diagnostic Observation Schedule-Generic (ADOS-G) total score. Laterality indexes of DFA were significantly correlated with ADOS-G total scores only in two intrafrontal connected areas (correlation was positive in one case and negative in the other). Laterality indexes of DTTL and DNUM showed significant negative correlations (P? En ligne : http://dx.doi.org/10.1002/aur.1533 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

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