Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood / Salvatore P. INSANA in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.551-564 Titre : Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood Type de document : texte imprimé Auteurs : Salvatore P. INSANA, Auteur ; Layla BANIHASHEMI, Auteur ; Ryan J. HERRINGA, Auteur ; David J. KOLKO, Auteur ; Anne GERMAIN, Auteur Article en page(s) : p.551-564 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health. En ligne : http://dx.doi.org/10.1017/S0954579415000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood [texte imprimé] / Salvatore P. INSANA, Auteur ; Layla BANIHASHEMI, Auteur ; Ryan J. HERRINGA, Auteur ; David J. KOLKO, Auteur ; Anne GERMAIN, Auteur . - p.551-564. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.551-564 Index. décimale : PER Périodiques Résumé : Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health. En ligne : http://dx.doi.org/10.1017/S0954579415000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity / Layla BANIHASHEMI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Titre : Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity Type de document : texte imprimé Auteurs : Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.1735-1747 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Childhood maltreatment moderates the effect of combat exposure on cingulum structural integrity [texte imprimé] / Layla BANIHASHEMI, Auteur ; Meredith L. WALLACE, Auteur ; Lei K. SHEU, Auteur ; Michael C. LEE, Auteur ; Peter J. GIANAROS, Auteur ; Robert P. MACKENZIE, Auteur ; Salvatore P. INSANA, Auteur ; Anne GERMAIN, Auteur ; Ryan J. HERRINGA, Auteur . - p.1735-1747. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1735-1747 Index. décimale : PER Périodiques Résumé : Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule. Using effect sizes, clinically meaningful moderator effects were found only within the CGH. Greater combat exposure was associated with decreased CGH fractional anisotropy (overall structural integrity) and increased CGH radial diffusivity (perpendicular water diffusivity) among individuals with more severe childhood maltreatment. Our findings provide preliminary evidence of the moderating effect of childhood maltreatment on the relationship between combat exposure and CGH structural integrity. These differences in CGH structural integrity could have maladaptive implications for emotion and memory, as well as provide a potential mechanism by which childhood maltreatment induces vulnerability to later life trauma exposure. En ligne : http://dx.doi.org/10.1017/S0954579417001365 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Commentary: Paediatric post-traumatic stress disorder from a neurodevelopmental network perspective: reflections on Weems et al. (2019) / Ryan HERRINGA in Journal of Child Psychology and Psychiatry, 60-4 (April 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-4 (April 2019) . - p.409-411 Titre : Commentary: Paediatric post-traumatic stress disorder from a neurodevelopmental network perspective: reflections on Weems et al. (2019) Type de document : texte imprimé Auteurs : Ryan HERRINGA, Auteur Article en page(s) : p.409-411 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Paediatric post-traumatic stress disorder (PTSD) is an incredibly heterogeneous and syndromic disorder that likely has a myriad of underlying neurobiological mechanisms at play. The disorder is even more complicated in youth, given that the expression of illness interacts with ongoing developmental processes. In their review in this issue, Weems and colleagues call for broader network-based approaches for studying the development and expression of PTSD in youth. In this commentary, I highlight some of the important knowledge gaps raised by Weems et al. and propose ways in which future studies may leverage network-based approaches for eventual translation into clinical care. Key concepts include the use of network-based approaches for understanding the emergence and maintenance of PTSD symptom architecture over development, identification of resilient and vulnerable patterns of symptom and brain network architecture following trauma, and consideration of how divergence between biological (e.g. brain) and chronological may inform our understanding of resilient and vulnerable patterns over development. Importantly, advancing and translating this work to clinical care will require larger, prospective studies assessing youth as early in development as possible, and integrating information across multiple research groups and sites. En ligne : https://dx.doi.org/10.1111/jcpp.13049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Commentary: Paediatric post-traumatic stress disorder from a neurodevelopmental network perspective: reflections on Weems et al. (2019) [texte imprimé] / Ryan HERRINGA, Auteur . - p.409-411. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-4 (April 2019) . - p.409-411 Index. décimale : PER Périodiques Résumé : Paediatric post-traumatic stress disorder (PTSD) is an incredibly heterogeneous and syndromic disorder that likely has a myriad of underlying neurobiological mechanisms at play. The disorder is even more complicated in youth, given that the expression of illness interacts with ongoing developmental processes. In their review in this issue, Weems and colleagues call for broader network-based approaches for studying the development and expression of PTSD in youth. In this commentary, I highlight some of the important knowledge gaps raised by Weems et al. and propose ways in which future studies may leverage network-based approaches for eventual translation into clinical care. Key concepts include the use of network-based approaches for understanding the emergence and maintenance of PTSD symptom architecture over development, identification of resilient and vulnerable patterns of symptom and brain network architecture following trauma, and consideration of how divergence between biological (e.g. brain) and chronological may inform our understanding of resilient and vulnerable patterns over development. Importantly, advancing and translating this work to clinical care will require larger, prospective studies assessing youth as early in development as possible, and integrating information across multiple research groups and sites. En ligne : https://dx.doi.org/10.1111/jcpp.13049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD / Sara A. HEYN in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.946-956 Titre : Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD Type de document : texte imprimé Auteurs : Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.946-956 Langues : Anglais (eng) Mots-clés : adolescent  emotion  functional neuroimaging  posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD [texte imprimé] / Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur . - p.946-956. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.946-956 Mots-clés : adolescent  emotion  functional neuroimaging  posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort / Quanfa HE in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort Type de document : texte imprimé Auteurs : Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort [texte imprimé] / Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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