Attenuated hypothalamic–pituitary–adrenal axis functioning predicts accelerated pubertal development in girls 1 year later / Darby SAXBE in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.819-828 Titre : Attenuated hypothalamic–pituitary–adrenal axis functioning predicts accelerated pubertal development in girls 1 year later Type de document : texte imprimé Auteurs : Darby SAXBE, Auteur ; Sonya NEGRIFF, Auteur ; Elizabeth J. SUSMAN, Auteur ; Penelope K. TRICKETT, Auteur Article en page(s) : p.819-828 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accelerated pubertal development has been linked to adverse early environments and may heighten subsequent mental and physical health risks. Hypothalamic–pituitary–adrenal axis functioning has been posited as a mechanism whereby stress may affect pubertal development, but the literature lacks prospective tests of this mechanism. The current study assessed 277 youth (M = 10.84 years, SD = 1.14), 138 boys and 139 girls, who reported on their pubertal development and underwent the Trier Social Stress Test for Children at baseline and returned to the laboratory approximately 1 year later (M = 1.12 years, range = 0.59–1.98 years). For girls, lower cortisol area under the curve (with respect to ground) at Time 1 predicted more advanced pubertal development at Time 2, controlling for Time 1 pubertal development. This association persisted after additional covariates including age, body mass index, race, and maltreatment history were introduced, and was driven by adrenal rather than gonadal development. Cortisol was not linked to boys' subsequent pubertal development, and no interaction by gender or by maltreatment appeared. These results suggest that attenuated cortisol, reported in other studies of children exposed to early adversity, may contribute to accelerated pubertal tempo in girls. En ligne : http://dx.doi.org/10.1017/S0954579414000790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Attenuated hypothalamic–pituitary–adrenal axis functioning predicts accelerated pubertal development in girls 1 year later [texte imprimé] / Darby SAXBE, Auteur ; Sonya NEGRIFF, Auteur ; Elizabeth J. SUSMAN, Auteur ; Penelope K. TRICKETT, Auteur . - p.819-828. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.819-828 Index. décimale : PER Périodiques Résumé : Accelerated pubertal development has been linked to adverse early environments and may heighten subsequent mental and physical health risks. Hypothalamic–pituitary–adrenal axis functioning has been posited as a mechanism whereby stress may affect pubertal development, but the literature lacks prospective tests of this mechanism. The current study assessed 277 youth (M = 10.84 years, SD = 1.14), 138 boys and 139 girls, who reported on their pubertal development and underwent the Trier Social Stress Test for Children at baseline and returned to the laboratory approximately 1 year later (M = 1.12 years, range = 0.59–1.98 years). For girls, lower cortisol area under the curve (with respect to ground) at Time 1 predicted more advanced pubertal development at Time 2, controlling for Time 1 pubertal development. This association persisted after additional covariates including age, body mass index, race, and maltreatment history were introduced, and was driven by adrenal rather than gonadal development. Cortisol was not linked to boys' subsequent pubertal development, and no interaction by gender or by maltreatment appeared. These results suggest that attenuated cortisol, reported in other studies of children exposed to early adversity, may contribute to accelerated pubertal tempo in girls. En ligne : http://dx.doi.org/10.1017/S0954579414000790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Neural mediators of the intergenerational transmission of family aggression / Darby SAXBE in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.595-606 Titre : Neural mediators of the intergenerational transmission of family aggression Type de document : texte imprimé Auteurs : Darby SAXBE, Auteur ; Larissa Borofsky DEL PIERO, Auteur ; Mary Helen IMMORDINO-YANG, Auteur ; Jonas Todd KAPLAN, Auteur ; Gayla MARGOLIN, Auteur Article en page(s) : p.595-606 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Youth exposed to family aggression may become more aggressive themselves, but the mechanisms of intergenerational transmission are understudied. In a longitudinal study, we found that adolescents’ reduced neural activation when rating their parents’ emotions, assessed via magnetic resonance imaging, mediated the association between parents’ past aggression and adolescents’ subsequent aggressive behavior toward parents. A subsample of 21 youth, drawn from the larger study, underwent magnetic resonance imaging scanning proximate to the second of two assessments of the family environment. At Time 1 (when youth were on average 15.51 years old) we measured parents’ aggressive marital and parent–child conflict behaviors, and at Time 2 (≈2 years later), we measured youth aggression directed toward parents. Youth from more aggressive families showed relatively less activation to parent stimuli in brain areas associated with salience and socioemotional processing, including the insula and limbic structures. Activation patterns in these same areas were also associated with youths’ subsequent parent-directed aggression. The association between parents’ aggression and youths’ subsequent parent-directed aggression was statistically mediated by signal change coefficients in the insula, right amygdala, thalamus, and putamen. These signal change coefficients were also positively associated with scores on a mentalizing measure. Hypoarousal of the emotional brain to family stimuli may support the intergenerational transmission of family aggression. En ligne : http://dx.doi.org/10.1017/S0954579415000528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Neural mediators of the intergenerational transmission of family aggression [texte imprimé] / Darby SAXBE, Auteur ; Larissa Borofsky DEL PIERO, Auteur ; Mary Helen IMMORDINO-YANG, Auteur ; Jonas Todd KAPLAN, Auteur ; Gayla MARGOLIN, Auteur . - p.595-606. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.595-606 Index. décimale : PER Périodiques Résumé : Youth exposed to family aggression may become more aggressive themselves, but the mechanisms of intergenerational transmission are understudied. In a longitudinal study, we found that adolescents’ reduced neural activation when rating their parents’ emotions, assessed via magnetic resonance imaging, mediated the association between parents’ past aggression and adolescents’ subsequent aggressive behavior toward parents. A subsample of 21 youth, drawn from the larger study, underwent magnetic resonance imaging scanning proximate to the second of two assessments of the family environment. At Time 1 (when youth were on average 15.51 years old) we measured parents’ aggressive marital and parent–child conflict behaviors, and at Time 2 (≈2 years later), we measured youth aggression directed toward parents. Youth from more aggressive families showed relatively less activation to parent stimuli in brain areas associated with salience and socioemotional processing, including the insula and limbic structures. Activation patterns in these same areas were also associated with youths’ subsequent parent-directed aggression. The association between parents’ aggression and youths’ subsequent parent-directed aggression was statistically mediated by signal change coefficients in the insula, right amygdala, thalamus, and putamen. These signal change coefficients were also positively associated with scores on a mentalizing measure. Hypoarousal of the emotional brain to family stimuli may support the intergenerational transmission of family aggression. En ligne : http://dx.doi.org/10.1017/S0954579415000528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

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