Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm / Alexandra M. URE in Autism Research, 9-5 (May 2016)  

Public ISBD [article]  inAutism Research > 9-5 (May 2016) . - p.543-552 Titre : Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.543-552 Langues : Anglais (eng) Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P?=?0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR?=?0.82, CI?=?0.66, 1.00, P?=?0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Neonatal brain abnormalities associated with autism spectrum disorder in children born very preterm [Texte imprimé et/ou numérique] / Alexandra M. URE, Auteur ; Karli TREYVAUD, Auteur ; Deanne K. THOMPSON, Auteur ; Leona PASCOE, Auteur ; Gehan ROBERTS, Auteur ; Katherine J. LEE, Auteur ; Marc L. SEAL, Auteur ; Elisabeth NORTHAM, Auteur ; Jeanie L. CHEONG, Auteur ; Rod W. HUNT, Auteur ; Terrie INDER, Auteur ; Lex W. DOYLE, Auteur ; Peter J. ANDERSON, Auteur . - p.543-552. Langues : Anglais (eng) in Autism Research > 9-5 (May 2016) . - p.543-552 Mots-clés : preterm birth  brain abnormality  autism spectrum disorder  magnetic resonance imaging  neonatal imaging Index. décimale : PER Périodiques Résumé : Very preterm (VP) survivors are at increased risk of autism spectrum disorder (ASD) compared with term-born children. This study explored whether neonatal magnetic resonance (MR) brain features differed in VP children with and without ASD at 7 years. One hundred and seventy-two VP children (<30 weeks' gestation or <1250 g birth weight) underwent structural brain MR scans at term equivalent age (TEA; 40 weeks' gestation ±2 weeks) and were assessed for ASD at 7 years of age. The presence and severity of white matter, cortical gray matter, deep nuclear gray matter, and cerebellar abnormalities were assessed, and total and regional brain volumes were measured. ASD was diagnosed using a standardized parent report diagnostic interview and confirmed via an independent assessment. Eight VP children (4.7%) were diagnosed with ASD. Children with ASD had more cystic lesions in the cortical white matter at TEA compared with those without ASD (odds ratio [OR] 8.7, 95% confidence interval [CI] 1.5, 51.3, P?=?0.02). There was also some evidence for smaller cerebellar volumes in children with ASD compared with those without ASD (OR?=?0.82, CI?=?0.66, 1.00, P?=?0.06). Overall, the results suggest that VP children with ASD have different brain structure in the neonatal period compared with those who do not have ASD. En ligne : http://dx.doi.org/10.1002/aur.1558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children / Karli TREYVAUD in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.814-821 Titre : Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children Type de document : Texte imprimé et/ou numérique Auteurs : Karli TREYVAUD, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Alexandra URE, Auteur ; Terrie E. INDER, Auteur ; Rod W. HUNT, Auteur ; Peter J. ANDERSON, Auteur Article en page(s) : p.814-821 Langues : Anglais (eng) Mots-clés : Preterm  child development  parent–child relationship  outcomes Index. décimale : PER Périodiques Résumé : Background Parenting influences child development, but it is unclear whether early parenting behavior can influence school-age outcomes in very preterm (VPT) children, and/or if certain groups of VPT children may be more affected by early parenting behavior. These research questions were examined. Methods Participants were 147 children born <30 weeks’ gestation or birth weight <1250 g and their primary caregiver. At term corrected age (CA), magnetic resonance imaging (MRI) was used to determine presence and severity of brain abnormality and medical data collected. High medical risk was defined as the presence of at least one of sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, moderate to severe white matter abnormality on MRI, or postnatal corticosteroids. At 2 years CA, parent–child interaction was assessed, and at 7 years CA, general intelligence (IQ), language, executive function, academic skills, and social-emotional functioning were assessed. Results Higher levels of parent–child synchrony, and parent facilitation, sensitivity and positive affect at 2 years were associated with better child outcomes at 7 years, while higher levels of intrusiveness and negative affect were associated with poorer outcomes. Many of these relationships remained after controlling for early child cognitive development. Interactions between child medical risk (higher/lower) and parenting were limited to child reading, math, and executive functioning outcomes, with stronger relationships for lower medical risk children. Conclusions The contribution of early parenting to VPT children's school-age performance is significant, with stronger effects for lower medical risk children in some outcomes. These findings support the premise that parenting strategies should be included in the NICU and early interventions programs for VPT infants. En ligne : http://dx.doi.org/10.1111/jcpp.12489 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Parenting behavior at 2 years predicts school-age performance at 7 years in very preterm children [Texte imprimé et/ou numérique] / Karli TREYVAUD, Auteur ; Lex W. DOYLE, Auteur ; Katherine J. LEE, Auteur ; Alexandra URE, Auteur ; Terrie E. INDER, Auteur ; Rod W. HUNT, Auteur ; Peter J. ANDERSON, Auteur . - p.814-821. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.814-821 Mots-clés : Preterm  child development  parent–child relationship  outcomes Index. décimale : PER Périodiques Résumé : Background Parenting influences child development, but it is unclear whether early parenting behavior can influence school-age outcomes in very preterm (VPT) children, and/or if certain groups of VPT children may be more affected by early parenting behavior. These research questions were examined. Methods Participants were 147 children born <30 weeks’ gestation or birth weight <1250 g and their primary caregiver. At term corrected age (CA), magnetic resonance imaging (MRI) was used to determine presence and severity of brain abnormality and medical data collected. High medical risk was defined as the presence of at least one of sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, moderate to severe white matter abnormality on MRI, or postnatal corticosteroids. At 2 years CA, parent–child interaction was assessed, and at 7 years CA, general intelligence (IQ), language, executive function, academic skills, and social-emotional functioning were assessed. Results Higher levels of parent–child synchrony, and parent facilitation, sensitivity and positive affect at 2 years were associated with better child outcomes at 7 years, while higher levels of intrusiveness and negative affect were associated with poorer outcomes. Many of these relationships remained after controlling for early child cognitive development. Interactions between child medical risk (higher/lower) and parenting were limited to child reading, math, and executive functioning outcomes, with stronger relationships for lower medical risk children. Conclusions The contribution of early parenting to VPT children's school-age performance is significant, with stronger effects for lower medical risk children in some outcomes. These findings support the premise that parenting strategies should be included in the NICU and early interventions programs for VPT infants. En ligne : http://dx.doi.org/10.1111/jcpp.12489 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

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