[article] 
inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - p.1

Titre :	Classifying and characterizing the development of adaptive behavior in a naturalistic longitudinal study of young children with autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	C. FARMER, Auteur ; L. SWINEFORD, Auteur ; Susan E. SWEDO, Auteur ; A. THURM, Auteur
Article en page(s) :	p.1
Langues :	Anglais (eng)
Mots-clés :	Adaptive behavior  Autism spectrum disorders  Longitudinal studies
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Adaptive behavior, or the ability to function independently in ones' environment, is a key phenotypic construct in autism spectrum disorder (ASD). Few studies of the development of adaptive behavior during preschool to school-age are available, though existing data demonstrate that the degree of ability and impairment associated with ASD, and how it manifests over time, is heterogeneous. Growth mixture models are a statistical technique that can help parse this heterogeneity in trajectories. METHODS: Data from an accelerated longitudinal natural history study (n = 105 children with ASD) were subjected to growth mixture model analysis. Children were assessed up to four times between the ages of 3 to 7.99 years. RESULTS: The best fitting model comprised two classes of trajectory on the Adaptive Behavior Composite score of the Vineland Adaptive Behavior Scale, Second Edition-a low and decreasing trajectory (73% of the sample) and a moderate and stable class (27%). CONCLUSIONS: These results partially replicate the classes observed in a previous study of a similarly characterized sample, suggesting that developmental trajectory may indeed serve as a phenotype. Further, the ability to predict which trajectory a child is likely to follow will be useful in planning for clinical trials.
En ligne :	http://dx.doi.org/10.1186/s11689-017-9222-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350

[article] Classifying and characterizing the development of adaptive behavior in a naturalistic longitudinal study of young children with autism [Texte imprimé et/ou numérique] / C. FARMER, Auteur ; L. SWINEFORD, Auteur ; Susan E. SWEDO, Auteur ; A. THURM, Auteur . - p.1.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - p.1

Mots-clés :	Adaptive behavior  Autism spectrum disorders  Longitudinal studies
Index. décimale :	PER Périodiques
Résumé :	BACKGROUND: Adaptive behavior, or the ability to function independently in ones' environment, is a key phenotypic construct in autism spectrum disorder (ASD). Few studies of the development of adaptive behavior during preschool to school-age are available, though existing data demonstrate that the degree of ability and impairment associated with ASD, and how it manifests over time, is heterogeneous. Growth mixture models are a statistical technique that can help parse this heterogeneity in trajectories. METHODS: Data from an accelerated longitudinal natural history study (n = 105 children with ASD) were subjected to growth mixture model analysis. Children were assessed up to four times between the ages of 3 to 7.99 years. RESULTS: The best fitting model comprised two classes of trajectory on the Adaptive Behavior Composite score of the Vineland Adaptive Behavior Scale, Second Edition-a low and decreasing trajectory (73% of the sample) and a moderate and stable class (27%). CONCLUSIONS: These results partially replicate the classes observed in a previous study of a similarly characterized sample, suggesting that developmental trajectory may indeed serve as a phenotype. Further, the ability to predict which trajectory a child is likely to follow will be useful in planning for clinical trials.
En ligne :	http://dx.doi.org/10.1186/s11689-017-9222-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350