Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain / Tiffany S. DOHERTY in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243 Titre : Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.1229-1243 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain [Texte imprimé et/ou numérique] / Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur . - p.1229-1243. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243 Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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